The AMPK (AMP-activated protein kinase) cascade plays a key role in regulating energy metabolism. Conditions which cause a decrease in the ATP/AMP ratio lead to activation of AMPK. Once activated, AMPK initiates a series of responses that act to restore the energy balance of the cell. In skeletal muscle, activation of AMPK increases both glucose uptake and fatty acid oxidation, raising the possibility that AMPK can bypass the glucose/fatty acid cycle. This review focuses on the role of AMPK in the regulation of glucose and fatty acid metabolism in muscle. Recently, naturally occurring mutations within the γ isoforms have been identified which lead to altered metabolic regulation in cardiac and skeletal muscle and suggest an important role for the kinase in regulating glycogen metabolism.
Skip Nav Destination
Article navigation
December 2003
- PDF Icon PDF LinkFront Matter
Conference Article|
December 01 2003
Bypassing the glucose/fatty acid cycle: AMP-activated protein kinase
D. Carling;
D. Carling
1
MRC Clinical Sciences Centre, Cellular Stress Group, Imperial College, Hammersmith Hospital Campus, DuCane Road, London W12 ONN, U.K.
1To whom correspondence should be addressed (e-mail dcarling@csc.mrc.ac.uk).
Search for other works by this author on:
L.G.D. Fryer;
L.G.D. Fryer
MRC Clinical Sciences Centre, Cellular Stress Group, Imperial College, Hammersmith Hospital Campus, DuCane Road, London W12 ONN, U.K.
Search for other works by this author on:
A. Woods;
A. Woods
MRC Clinical Sciences Centre, Cellular Stress Group, Imperial College, Hammersmith Hospital Campus, DuCane Road, London W12 ONN, U.K.
Search for other works by this author on:
T. Daniel;
T. Daniel
MRC Clinical Sciences Centre, Cellular Stress Group, Imperial College, Hammersmith Hospital Campus, DuCane Road, London W12 ONN, U.K.
Search for other works by this author on:
S.L.C. Jarvie;
S.L.C. Jarvie
MRC Clinical Sciences Centre, Cellular Stress Group, Imperial College, Hammersmith Hospital Campus, DuCane Road, London W12 ONN, U.K.
Search for other works by this author on:
H. Whitrow
H. Whitrow
MRC Clinical Sciences Centre, Cellular Stress Group, Imperial College, Hammersmith Hospital Campus, DuCane Road, London W12 ONN, U.K.
Search for other works by this author on:
Publisher: Portland Press Ltd
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2003 Biochemical Society
2003
Biochem Soc Trans (2003) 31 (6): 1157–1160.
Citation
D. Carling, L.G.D. Fryer, A. Woods, T. Daniel, S.L.C. Jarvie, H. Whitrow; Bypassing the glucose/fatty acid cycle: AMP-activated protein kinase. Biochem Soc Trans 1 December 2003; 31 (6): 1157–1160. doi: https://doi.org/10.1042/bst0311157
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.