The link between raised levels of LDL (low-density lipoprotein) cholesterol in the blood and atherosclerosis is incontrovertible. The situation with regard to TRLs (triacylglycerol-rich lipoproteins) is not as clear. Nevertheless, there is substantial evidence that TRLs may in some cases be just as atherogenic as triacylglycerol-poor LDL. This review focuses on three aspects of the link between TRLs and atherosclerosis: (i) the epidemiological evidence for an association between raised levels of TRLs and atherosclerosis, with particular reference to the results of the PROCAM study; (ii) the possible pathophysiological contribution of TRL to atherogenesis at the level of the arterial wall; and (iii) the case for specific lowering of triacylglycerol levels to prevent atherosclerosis.
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October 2003
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Conference Article|
October 01 2003
Triacylglycerol-rich lipoproteins and atherosclerosis – where is the link?
P. Cullen
P. Cullen
1
Institut für Arterioskleroseforschung, Domagkstrasse 3, D-48149 Münster, Germany
1e-mail cullen@uni-muenster.de
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Publisher: Portland Press Ltd
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2003 Biochemical Society
2003
Biochem Soc Trans (2003) 31 (5): 1080–1084.
Citation
P. Cullen; Triacylglycerol-rich lipoproteins and atherosclerosis – where is the link?. Biochem Soc Trans 1 October 2003; 31 (5): 1080–1084. doi: https://doi.org/10.1042/bst0311080
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