Protein L is a multidomain cell-wall protein isolated from Peptostreptococcus magnus. It belongs to a group of proteins that contain repeated domains that are able to bind to Igs without stimulating an immune response, the most characterized of this group being Protein A (Staphylococcus aureus) and Protein G (Streptococcus). Both of these proteins bind predominantly to the interface of CH2-CH3 heavy chains, while Protein L binds exclusively to the VL domain of the κ-chain. The function of these proteins in vivo is not clear but it is thought that they enable the bacteria to evade the host's immune system. Two binding sites for κ-chain on a single Ig-binding domain from Protein L have recently been reported and we give evidence that one site has a 25–55-fold higher affinity for κ-chain than the second site.
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Conference Article|
June 01 2003
Immunoglobulin-binding domains: Protein L from Peptostreptococcus magnus
N.G. Housden;
N.G. Housden
*Division of Biochemistry and Molecular Biology, Institute of Biomolecular Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, U.K.
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S. Harrison;
S. Harrison
*Division of Biochemistry and Molecular Biology, Institute of Biomolecular Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, U.K.
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S.E. Roberts;
S.E. Roberts
*Division of Biochemistry and Molecular Biology, Institute of Biomolecular Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, U.K.
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J.A. Beckingham;
J.A. Beckingham
*Division of Biochemistry and Molecular Biology, Institute of Biomolecular Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, U.K.
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M. Graille;
M. Graille
†Laboratoire de Structure des Protèines, DIEP, CEA, Centre d'Etudes de Saclay, Gif-sur-Yvette, F91191, France
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E. Stura;
E. Stura
†Laboratoire de Structure des Protèines, DIEP, CEA, Centre d'Etudes de Saclay, Gif-sur-Yvette, F91191, France
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M.G. Gore
M.G. Gore
1
*Division of Biochemistry and Molecular Biology, Institute of Biomolecular Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, U.K.
1To whom correspondence should be addressed (e-mail m.g.gore@soton.ac.uk).
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Publisher: Portland Press Ltd
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2003 Biochemical Society
2003
Biochem Soc Trans (2003) 31 (3): 716–718.
Citation
N.G. Housden, S. Harrison, S.E. Roberts, J.A. Beckingham, M. Graille, E. Stura, M.G. Gore; Immunoglobulin-binding domains: Protein L from Peptostreptococcus magnus. Biochem Soc Trans 1 June 2003; 31 (3): 716–718. doi: https://doi.org/10.1042/bst0310716
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