Studies of the DNA-replication machinery of Archaea have revealed striking similarities to that of eukaryotes. Indeed, it appears that in most cases Archaea possess a simplified version of the eukaryotic replication apparatus. Studies of Archaea are therefore shedding light on the fundamental processes of DNA replication in both domains of life.

Keywords:
Archaea, evolution, lagging strand, proliferating, cell nuclear antigen (PCNA), replication
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© 2003 Biochemical Society
2003
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