Cytochrome P450 reductase (CPR) is a diflavin enzyme responsible for electron donation to mammalian cytochrome P450 enzymes in the endoplasmic reticulum. Dissection of the enzyme into functional domains and studies by site-directed mutagenesis have enabled detailed characterization of the mechanism of electron transfer using stopped-flow and equilibrium-perturbation methods, and redox potentiometry. These studies and the mechanism of electron transfer in CPR are reported herein.
Electron transfer in human cytochrome P450 reductase
- Views Icon Views
- Share Icon Share
A. Gutierrez, A. Grunau, M. Paine, A.W. Munro, C.R. Wolf, G.C.K. Roberts, N.S. Scrutton; Electron transfer in human cytochrome P450 reductase. Biochem Soc Trans 1 June 2003; 31 (3): 497–501. doi: https://doi.org/10.1042/bst0310497
Download citation file: