Exercise-induced glucose uptake in skeletal muscle is mediated by an insulin-independent mechanism, but the actual signals to glucose transport in response to muscle contraction have not been identified. The 5´-AMP-activated protein kinase (AMPK) has emerged as a putative mediator of contraction-induced glucose transport, although no conclusive evidence has been provided so far. Recent experiments in AMPK transgenic mice suggest that glucose transport induced by 5-amino-4-imidazolecarboxamide riboside (AICAR) or hypoxia is mediated by AMPK. In contrast, contraction-induced glucose transport in rodent skeletal muscle induced by electrical stimulation in vitro or in situ is not influenced or is only partially reduced by abolishing both or one of the catalytic AMPK subunits. This is compatible with exercise studies done in humans, where no tight correlation is found between AMPK activity and glucose uptake during exercise. Taken together, these results question an essential role of AMPK in exercise-induced glucose uptake and imply that one or more additional pathways are involved in mediating glucose transport in skeletal muscle during exercise.
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February 2003
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Conference Article|
February 01 2003
A possible role for AMP-activated protein kinase in exercise-induced glucose utilization: insights from humans and transgenic animals
J.N. Nielsen;
J.N. Nielsen
1
*Copenhagen Muscle Research Centre, Institute of Exercise and Sports Sciences, Department of Human Physiology, University of Copenhagen, Denmark
1To whom correspondence should be addressed, at Universitetsparken 13, DK-2100 Copenhagen, Denmark (e-mail jnnielsen@aki.ku.dk).
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S.B. Jørgensen;
S.B. Jørgensen
*Copenhagen Muscle Research Centre, Institute of Exercise and Sports Sciences, Department of Human Physiology, University of Copenhagen, Denmark
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C. Frøsig;
C. Frøsig
*Copenhagen Muscle Research Centre, Institute of Exercise and Sports Sciences, Department of Human Physiology, University of Copenhagen, Denmark
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B. Viollet;
B. Viollet
†Department of Genetics, Development and Molecular Pathology, Institut Cochin-INSERM-CNRS-René Descartes University, Paris, France
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F. Andreelli;
F. Andreelli
†Department of Genetics, Development and Molecular Pathology, Institut Cochin-INSERM-CNRS-René Descartes University, Paris, France
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S. Vaulont;
S. Vaulont
†Department of Genetics, Development and Molecular Pathology, Institut Cochin-INSERM-CNRS-René Descartes University, Paris, France
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B. Kiens;
B. Kiens
*Copenhagen Muscle Research Centre, Institute of Exercise and Sports Sciences, Department of Human Physiology, University of Copenhagen, Denmark
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E.A. Richter;
E.A. Richter
*Copenhagen Muscle Research Centre, Institute of Exercise and Sports Sciences, Department of Human Physiology, University of Copenhagen, Denmark
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J.F.P. Wojtaszewski
J.F.P. Wojtaszewski
*Copenhagen Muscle Research Centre, Institute of Exercise and Sports Sciences, Department of Human Physiology, University of Copenhagen, Denmark
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Publisher: Portland Press Ltd
Online ISSN: 1470-8752
Print ISSN: 0300-5127
Copyright 2003 Biochemical Society
2003
Biochem Soc Trans (2003) 31 (1): 186–190.
Citation
J.N. Nielsen, S.B. Jørgensen, C. Frøsig, B. Viollet, F. Andreelli, S. Vaulont, B. Kiens, E.A. Richter, J.F.P. Wojtaszewski; A possible role for AMP-activated protein kinase in exercise-induced glucose utilization: insights from humans and transgenic animals. Biochem Soc Trans 1 February 2003; 31 (1): 186–190. doi: https://doi.org/10.1042/bst0310186
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