The receptors for the neuropeptides vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide are strong activators of adenylate cyclase, but recent evidence suggests that they can elicit a number of additional intracellular signals. Some of these are likely to be downstream of the conventional adenylate cyclase pathway, but it is now clear that others reflect novel primary coupling events of the receptors.
Keywords:
ADP-ribosylation factor,
G-protein,
phospholipases C/D,
pituitary adenylate cyclase-activating polypeptide (PACAP),
vasoactive intestinal polypeptide (VIP),
ARF, ADP-ribosylation factor,
ERK, extracellular-signal-regulated kinase,
GPCR, G-protein-coupled receptor,
GRK, GPCR kinase,
PACAP, pituitary adenylate cyclase-activating polypeptide
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© 2002 Biochemical Society
2002
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