Calcitonin is a 32-amino-acid peptide hormone that is produced by parafollicular cells of the thyroid gland in response to increased levels of extracellular calcium. In this article we review our previous and current research on the transcriptional regulation of the pig and human calcitonin receptor (CTR) gene. Initially, our experiments on the transcriptional analysis of the pig CTR gene in transgenic mice are examined, followed by our studies on the cloning of the human CTR (hCTR) gene promoter and its transcriptional activity in hCTR-positive cell lines. We further describe the activity of the hCTR promoter in transgenic mice and review current experiments to identify transcriptional regulatory elements and the transcription factors they interact with, which direct the tissue-specific expression pattern of hCTR promoter activity.
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August 2002
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Conference Article|
August 01 2002
Transcriptional regulation of the calcitonin receptor gene
M. D. Pondel;
M. D. Pondel
1
1Department of Cellular Pathology, St. George's Hospital Medical School, Cranmer Terrace, London SW17 ORE, U.K.
1To whom correspondence should be addressed (e-mail mpondel@sghms.ac.uk)
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C. Jagger;
C. Jagger
1Department of Cellular Pathology, St. George's Hospital Medical School, Cranmer Terrace, London SW17 ORE, U.K.
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C. Hebden;
C. Hebden
1Department of Cellular Pathology, St. George's Hospital Medical School, Cranmer Terrace, London SW17 ORE, U.K.
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G. Partington;
G. Partington
1Department of Cellular Pathology, St. George's Hospital Medical School, Cranmer Terrace, London SW17 ORE, U.K.
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R. Mould
R. Mould
1Department of Cellular Pathology, St. George's Hospital Medical School, Cranmer Terrace, London SW17 ORE, U.K.
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Publisher: Portland Press Ltd
Received:
April 10 2002
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2002 Biochemical Society
2002
Biochem Soc Trans (2002) 30 (4): 423–427.
Article history
Received:
April 10 2002
Citation
M. D. Pondel, C. Jagger, C. Hebden, G. Partington, R. Mould; Transcriptional regulation of the calcitonin receptor gene. Biochem Soc Trans 1 August 2002; 30 (4): 423–427. doi: https://doi.org/10.1042/bst0300423
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