14-3-3 proteins are conserved multifunctional molecules, involved in many biological processes. Several 14-3-3 isoforms were recently shown to be cruciform DNA-binding proteins, which is a new activity ascribed to the 14-3-3 family. As cruciform-binding proteins, 14-3-3 proteins are putatively involved in the regulation of DNA replication. Inverted repeat sequences that are able to extrude into cruciform structures are a common feature of replication origins in both prokaryotes and eukaryotes. The involvement of cruciform structures in the initiation of DNA replication has been demonstrated. A leading model of 14-3-3 function proposes that they facilitate critical protein-protein interactions, thus serving as a central component of a wide variety of cellular processes.
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August 2002
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Conference Article|
August 01 2002
14-3-3s are DNA-replication proteins
M. Zannis-Hadjopoulos;
M. Zannis-Hadjopoulos
1
*McGill Cancer Centre, 3655 Promenade Sir William Osler, Montreal, Quebec H3G IY6, Canada
†Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G IY6, Canada
1To whom correspondence should be addressed (e-mail maria.zannis@mcgill.ca)
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O. Novac;
O. Novac
*McGill Cancer Centre, 3655 Promenade Sir William Osler, Montreal, Quebec H3G IY6, Canada
†Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G IY6, Canada
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D. Alvarez;
D. Alvarez
*McGill Cancer Centre, 3655 Promenade Sir William Osler, Montreal, Quebec H3G IY6, Canada
†Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G IY6, Canada
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G. B. Price
G. B. Price
*McGill Cancer Centre, 3655 Promenade Sir William Osler, Montreal, Quebec H3G IY6, Canada
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Publisher: Portland Press Ltd
Received:
April 10 2002
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2002 Biochemical Society
2002
Biochem Soc Trans (2002) 30 (4): 397–401.
Article history
Received:
April 10 2002
Citation
M. Zannis-Hadjopoulos, O. Novac, D. Alvarez, G. B. Price; 14-3-3s are DNA-replication proteins. Biochem Soc Trans 1 August 2002; 30 (4): 397–401. doi: https://doi.org/10.1042/bst0300397
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