The 14-3-3 proteins are a family of phosphoserine/phosphothreonine-binding molecules that control the function of a wide array of cellular proteins. We suggest that one function of 14-3-3 is to support cell survival. 14-3-3 proteins promote survival in part by antagonizing the activity of associated proapoptotic proteins, including Bad and apoptosis signal-regulating kinase 1 (ASK1). Indeed, expression of 14-3-3 inhibitor peptides in cells is sufficient to induce apoptosis. Interestingly, these 14-3-3 antagonist peptides can sensitize cells for effective killing by anticancer agents such as cisplatin. Thus, 14-3-3 may be part of the cellular machinery that maintains cell survival, and targeting 14-3-3-ligand interactions may be a useful strategy to enhance the efficacy of conventional anticancer agents.
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August 2002
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Conference Article|
August 01 2002
Survival-promoting functions of 14-3-3 proteins
S. C. Masters;
S. C. Masters
1Department of Pharmacology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, U.S.A.
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R. R. Subramanian;
R. R. Subramanian
1Department of Pharmacology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, U.S.A.
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A. Truong;
A. Truong
1Department of Pharmacology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, U.S.A.
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H. Yang;
H. Yang
1Department of Pharmacology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, U.S.A.
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K. Fujii;
K. Fujii
1Department of Pharmacology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, U.S.A.
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H. Zhang;
H. Zhang
1Department of Pharmacology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, U.S.A.
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H. Fu
H. Fu
1
1Department of Pharmacology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, U.S.A.
1To whom correspondence should be addressed (e-mail hfu@emory.edu)
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Publisher: Portland Press Ltd
Received:
March 20 2002
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2002 Biochemical Society
2002
Biochem Soc Trans (2002) 30 (4): 360–365.
Article history
Received:
March 20 2002
Citation
S. C. Masters, R. R. Subramanian, A. Truong, H. Yang, K. Fujii, H. Zhang, H. Fu; Survival-promoting functions of 14-3-3 proteins. Biochem Soc Trans 1 August 2002; 30 (4): 360–365. doi: https://doi.org/10.1042/bst0300360
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