Stoicheiometric analysis of metabolic pathways provides a systematic way of determining which metabolite concentrations are subject to constraints, information that may otherwise be very difficult to recognize in a large branched pathway. The procedure involves representing the pathway structure in the form of a matrix and then carrying out row operations to convert the matrix into ‘row echelon form’: this is a form in which as many as possible of the elements on the main diagonal are non-zero, and all of the elements below the main diagonal are zero. If exactly the same operations are carried out on a unit matrix of order equal to the number of intermediate metabolites in the pathway, the resulting matrix allows the stoicheiometric constraints to be read off directly.
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Conference Article|
April 01 2002
Stoicheiometric analysis in studies of metabolism
Athel Cornish-Bowden;
Athel Cornish-Bowden
1
*Bioénergétique et Ingénierie des Protéines, Institut Fédératif “Biologie Structurale et Microbiologie”, Centre National de la Recherche Scientifique, 31 chemin Joseph-Aiguier, B.P. 71, 13402 Marseille Cedex 20, France
1To whom correspondence should be addressed (e-mail athel@ibsm.cnrs-mrs.fr).
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Jan-Hendrik S. Hofmeyr;
Jan-Hendrik S. Hofmeyr
†Department of Biochemistry, University of Stellenbosch, Stellenbosch 7600, South Africa
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María Luz Cárdenas
María Luz Cárdenas
*Bioénergétique et Ingénierie des Protéines, Institut Fédératif “Biologie Structurale et Microbiologie”, Centre National de la Recherche Scientifique, 31 chemin Joseph-Aiguier, B.P. 71, 13402 Marseille Cedex 20, France
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Publisher: Portland Press Ltd
Received:
November 19 2001
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2002 Biochemical Society
2002
Biochem Soc Trans (2002) 30 (2): 43–46.
Article history
Received:
November 19 2001
Citation
Athel Cornish-Bowden, Jan-Hendrik S. Hofmeyr, María Luz Cárdenas; Stoicheiometric analysis in studies of metabolism. Biochem Soc Trans 1 April 2002; 30 (2): 43–46. doi: https://doi.org/10.1042/bst0300043
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