Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) are both powerful, non-invasive methodologies and, as such, offer great potential to investigate both human biochemistry and human physiology, and ultimately to contribute significantly to the field of medicine. Consequently there has been much effort devoted to fostering the evolution of these methodologies into distinct and applicable techniques. Here we will highlight several MRI and MRS techniques for the assessment of human biochemistry and physiology that ultimately may provide useful clinical assessments and diagnoses of various muscular and cardiovascular pathologies. Specifically, the evolving techniques that will be discussed are: (1) 1H MRS of myoglobin to assess the intracellular partial pressure of O2, (2) 31P MRS to assess metabolic capacity, and (3) the combination of 31P chemical shift imaging to assess local metabolic demand (oxygen uptake; o2) with arterial spin labelling to assess local perfusion (blood flow; ), in an effort to characterize the elusive spatial matching of skeletal muscle (/o2).
Skip Nav Destination
Article navigation
April 2002
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkAdvertising
Conference Article|
April 01 2002
Evolving techniques for the investigation of muscle bioenergetics and oxygenation
R. S. Richardson;
R. S. Richardson
1
1Department of Medicine 0623A, 9500 Gilman Drive, University of California San Diego, La Jolla, CA 92093-0623, U.S.A.
1To whom correspondence should be addressed (e-mail mchardson@ucsd.edu).
Search for other works by this author on:
E. A. Noyszewski;
E. A. Noyszewski
1Department of Medicine 0623A, 9500 Gilman Drive, University of California San Diego, La Jolla, CA 92093-0623, U.S.A.
Search for other works by this author on:
L. J. Haseler;
L. J. Haseler
1Department of Medicine 0623A, 9500 Gilman Drive, University of California San Diego, La Jolla, CA 92093-0623, U.S.A.
Search for other works by this author on:
S. Bluml;
S. Bluml
1Department of Medicine 0623A, 9500 Gilman Drive, University of California San Diego, La Jolla, CA 92093-0623, U.S.A.
Search for other works by this author on:
L. R. Frank
L. R. Frank
1Department of Medicine 0623A, 9500 Gilman Drive, University of California San Diego, La Jolla, CA 92093-0623, U.S.A.
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
December 19 2001
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2002 Biochemical Society
2002
Biochem Soc Trans (2002) 30 (2): 232–237.
Article history
Received:
December 19 2001
Citation
R. S. Richardson, E. A. Noyszewski, L. J. Haseler, S. Bluml, L. R. Frank; Evolving techniques for the investigation of muscle bioenergetics and oxygenation. Biochem Soc Trans 1 April 2002; 30 (2): 232–237. doi: https://doi.org/10.1042/bst0300232
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.