The local balance between proteinase inhibitors and proteinases determines local proteolytic activity. Various studies have demonstrated the importance of serine proteinase inhibitors in regulating the activity of serine proteinases that are released by leucocytes during inflammation. Recently it has been shown that these inhibitors may also display functions that are distinct from those associated with the inhibition of leucocyte-derived proteinases. In this review the results of selected studies focusing on three inhibitors of neutrophil elastase, i.e. α1-proteinase inhibitor, secretory leucocyte proteinase inhibitor and elafin, are presented, with the aim of illustrating their possible involvement in the regulation of inflammation, host defence against infection, tissue repair and extracellular matrix synthesis.
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Conference Article| April 01 2002
Novel roles of protease inhibitors in infection and inflammation
P. S. Hiemstra
P. S. Hiemstra 1
1Department of Pulmonology, Building I, C3-P, Leiden University Medical Center (LUMC), P.O. Box 9600, 2300 RC Leiden, The Netherlands
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Biochem Soc Trans (2002) 30 (2): 116–120.
December 19 2001
P. S. Hiemstra; Novel roles of protease inhibitors in infection and inflammation. Biochem Soc Trans 1 April 2002; 30 (2): 116–120. doi: https://doi.org/10.1042/bst0300116
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