It is well established that the class-I phosphoinositide (PI) 3-kinases play a crucial role in growth factor signalling pathways. However, evidence has recently emerged that the alpha isoform of the class-II PI 3-kinase (PI 3K-C2α) is activated by growth factors, although the consequences of this are poorly understood. Here we demonstrate that the activation of PI 3K-C2aL is not associated with a change in subcellular localization. Furthermore, we provide the first evidence that PI 3K-C2β is activated by insulin, albeit with slower kinetics than activation of PI 3K-C2α. These findings suggest that both these class-II PI 3-kinase isoforms are likely to participate in insulin-signalling pathways in the cell.

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