This brief review focuses on the transcriptional regulation of liver carnitine palmitoyltransferase I (L-CPT I) by pancreatic and thyroid hormones and by long-chain fatty acids (LCFA). Both glucagon and 3,3′,5-tri-iodothyronine (T3) enhanced the transcription of the gene encoding L-CPT I, whereas insulin had the opposite effect. Interestingly, the transcriptional effect of T3 required, in addition to the thyroid-responsive element, the co-operation of a sequence located in the first intron of L-CPT I gene. Non-esterified fatty acids rather than acyl-CoA ester or intramitochondrial metabolite were responsible for the transcriptional effect on the gene encoding LCPT I. It was shown that LCFA and peroxisome proliferators stimulated L-CPT I gene transcription by distinct mechanisms. Peroxisome proliferator stimulated L-CPT I gene transcription through a peroxisome-proliferator-responsive element (PPRE) located at -2846 bp, whereas LCFA induced L-CPT I gene transcription through a peroxisome-proliferator-activated receptor α (PPARα)-independent mechanism owing to a sequence located in the first intron of the gene.
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Conference Article|
May 01 2001
Regulation of liver carnitine palmitoyltransferase I gene expression by hormones and fatty acids
J.-F. Louet;
J.-F. Louet
1Centre de Recherche sur I'Endocrinologie Moléculaire et le Développement, UPR 1524 CNRS, 9 rue Jules Hetzel, 92190 Meudon, France
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C. Le May;
C. Le May
1Centre de Recherche sur I'Endocrinologie Moléculaire et le Développement, UPR 1524 CNRS, 9 rue Jules Hetzel, 92190 Meudon, France
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J.-P. Pégorier;
J.-P. Pégorier
1
1Centre de Recherche sur I'Endocrinologie Moléculaire et le Développement, UPR 1524 CNRS, 9 rue Jules Hetzel, 92190 Meudon, France
1To whom correspondence should be addressed (e-mail pegorier@infobiogen.fr)
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J.-F. Decaux;
J.-F. Decaux
1Centre de Recherche sur I'Endocrinologie Moléculaire et le Développement, UPR 1524 CNRS, 9 rue Jules Hetzel, 92190 Meudon, France
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J. Girard
J. Girard
1Centre de Recherche sur I'Endocrinologie Moléculaire et le Développement, UPR 1524 CNRS, 9 rue Jules Hetzel, 92190 Meudon, France
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Publisher: Portland Press Ltd
Received:
December 08 2000
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2001 Biochemical Society
2001
Biochem Soc Trans (2001) 29 (2): 310–316.
Article history
Received:
December 08 2000
Citation
J.-F. Louet, C. Le May, J.-P. Pégorier, J.-F. Decaux, J. Girard; Regulation of liver carnitine palmitoyltransferase I gene expression by hormones and fatty acids. Biochem Soc Trans 1 May 2001; 29 (2): 310–316. doi: https://doi.org/10.1042/bst0290310
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