The generation and metabolism of bioactive peptides involves a series of highly ordered proteolytic events. This post-translational processing can occur either within the cell, at the cell surface or after secretion. In the central nervous system a number of extracellular peptidases have been implicated in the regulated processing of peptides, particularly in the regulation of neuroendocrine function. The aim of this study has been to identify the peptidases involved in the metabolism of gonadotropin-releasing hormone (GnRH) and to characterize the factors and the mechanisms by which the activity of these peptidases are regulated. We have shown that both prolylendo-peptidase and the thimet oligopeptidase EC 3.4.24.15 are involved in GnRH metabolism and that both oestrogen and thiol-based reductants could be involved in the physiological regulation of their activities.
Skip Nav Destination
Article navigation
August 2000
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkAdvertising
Conference Article|
August 01 2000
Neuropeptidases regulating gonadal function
A. I. Smith;
A. I. Smith
1
*Baker Medical Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
1To whom correspondence should be addressed (e-mail ian.smith@baker.edu.au)
Search for other works by this author on:
C. N. Shrimpton;
C. N. Shrimpton
*Baker Medical Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
Search for other works by this author on:
U. M. Norman;
U. M. Norman
*Baker Medical Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
Search for other works by this author on:
I. J. Clarke;
I. J. Clarke
†Prince Henry's Institute for Medical Research, Monash Medical Centre, Clayton, Victoria 3168, Australia
Search for other works by this author on:
A. J. Wolfson;
A. J. Wolfson
‡Department of Chemistry, Wellesley College, Wellesley, MA 02181, U.S.A.
Search for other works by this author on:
R. A. Lew
R. A. Lew
*Baker Medical Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
March 06 2000
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2000 Biochemical Society
2000
Biochem Soc Trans (2000) 28 (4): 430–434.
Article history
Received:
March 06 2000
Citation
A. I. Smith, C. N. Shrimpton, U. M. Norman, I. J. Clarke, A. J. Wolfson, R. A. Lew; Neuropeptidases regulating gonadal function. Biochem Soc Trans 1 August 2000; 28 (4): 430–434. doi: https://doi.org/10.1042/bst0280430
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.