Hepatocyte couplets, by retaining functional and morphological polarity similar to that of hepatocytes in situ, are a valuable in vitro model to study mechanisms of bile secretion, cholestasis and hepatocellular injury. They have been useful in studies of the hormonal control of bile formation and are suitable for morphological studies. The availability of periportal- and perivenous-enriched couplet populations now allows a zonal perspective. Their contribution to our understanding of regulatory aspects of hepatobiliary dysfunction due to toxicological or cholestatic insult, as well as its reversion by using hepatoprotective agents, is still at an early stage. The next few years should see further exiting contributions to our understanding of hepatobiliary function and dysfunction.
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February 2000
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Conference Article|
February 01 2000
Hepatocyte couplets
R. Coleman;
R. Coleman
1
*School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U. K.
1To whom correspondence should be addressed.
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M. G. Roma
M. G. Roma
†RInstitute of Experimental Physiology, University of Rosario, Argentina
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Publisher: Portland Press Ltd
Received:
August 06 1999
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2000 Biochemical Society
2000
Biochem Soc Trans (2000) 28 (2): 136–140.
Article history
Received:
August 06 1999
Citation
R. Coleman, M. G. Roma; Hepatocyte couplets. Biochem Soc Trans 1 February 2000; 28 (2): 136–140. doi: https://doi.org/10.1042/bst0280136
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