Phosphorus magnetic resonance spectroscopy, despite some limitations, is a valuable non-invasive window on muscle metabolism in vivo, particularly oxidative ATP synthesis. A number of experiments have shown this to be dominated by closed-loop feedback mechanisms: a well-known model posits regulation by ADP, but there are others, difficult to distinguish experimentally. Moreover the contribution of open-loop control mechanisms (‘feed forward’ or ‘parallel activation’) in vivo remains controversial. Progress will require more precise data, better integrated with other measurements (e.g. muscle oxygenation), and improvement of the conceptual tools appropriate to such studies, where data are limited and steady-state assumptions frequently inapplicable.
Skip Nav Destination
Article navigation
February 2000
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
February 01 2000
Studying metabolic regulation in human muscle
G. J. Kemp
G. J. Kemp
1Department of Musculoskeletal Science, University of Liverpool, Liverpool L69 3GA, U.K.
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
August 06 1999
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2000 Biochemical Society
2000
Biochem Soc Trans (2000) 28 (2): 100–103.
Article history
Received:
August 06 1999
Citation
G. J. Kemp; Studying metabolic regulation in human muscle. Biochem Soc Trans 1 February 2000; 28 (2): 100–103. doi: https://doi.org/10.1042/bst0280100
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.