Phosphoinositide signals regulate cell proliferation, differentiation, cytoskeletal rearrangement and intracellular trafficking. Hydrolysis of PtdIns(4,5)P2 and PtdIns(3,4,5)P3, by inositol polyphosphate 5-phosphatases regulates synaptic vesicle recycling (synaptojanin-1), hematopoietic cell function [SHIP1(SH2-containing inositol polyphosphate 5-phosphatase-1)], renal cell function [OCRL (oculocerebrorenal syndrome of Lowe)] and insulin signalling (SHIP2). We present here a detailed review of the characteristics of the ten mammalian 5-phosphatases. Knockout mouse phenotypes and underexpression studies are associated with significant phenotypic changes, indicating non-redundant roles, despite, in many cases, overlapping substrate specificity and tissue expression. The extraordinary complexity in the control of phosphoinositide signalling continues to be revealed.
The inositol polyphosphate 5-phosphatases: traffic controllers, waistline watchers and tumour suppressors?
Michael J.O. Wakelam, Megan V. Astle, Kristy A. Horan, Lisa M. Ooms, Christina A. Mitchell; The inositol polyphosphate 5-phosphatases: traffic controllers, waistline watchers and tumour suppressors?. Biochem Soc Symp 12 January 2007; 74 161–181. doi: https://doi.org/10.1042/BSS2007c15
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