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Keywords: zinc finger
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Biochem J (2018) 475 (16): 2667–2679.
Published: 31 August 2018
... of telomere maintenance recruit NuRD to their telomeres. This interaction is mediated by the N-terminal domain of the zinc-finger protein ZNF827. NuRD–ZNF827 plays a vital role in the ALT pathway by creating a molecular platform for recombination-mediated repair. Disruption of NuRD binding results in loss...
Articles
Biochem J (2014) 461 (1): 15–32.
Published: 13 June 2014
...Eneda Toska; Stefan G. E. Roberts The WT1 (Wilms’ tumour 1) gene encodes a zinc finger transcription factor and RNA-binding protein that direct the development of several organs and tissues. WT1 manifests both tumour suppressor and oncogenic activities, but the reasons behind these opposing...
Articles
Biochem J (2013) 454 (3): 427–435.
Published: 29 August 2013
... DHHC domain suggests that it could fold as a zinc-finger domain, co-ordinating two zinc atoms in a CCHC arrangement. All residues predicted to be involved in the co-ordination of zinc were found to be essential for Swf1 function in the screen. Moreover, these mutations result in unstable proteins...
Includes: Supplementary data
Articles
Biochem J (2013) 454 (1): 39–47.
Published: 26 July 2013
... of the activation loop. © The Authors Journal compilation © 2013 Biochemical Society 2013 activation loop hydrophobic motif mammalian target of rapamycin (mTOR) signalling phosphorylation ribosomal protein subunit 6 kinase 1 (S6K1) zinc finger 1 To whom correspondence should be addressed...
Includes: Supplementary data
Articles
Biochem J (2012) 445 (3): 431–439.
Published: 13 July 2012
.... 1 To whom correspondence should be addressed (email bcuevas@lumc.edu ). 6 3 2012 7 5 2012 14 5 2012 14 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 c-Jun MEKK1 protein kinase transcription factor ubiquitylation zinc finger...
Includes: Supplementary data
Articles
Biochem J (2012) 441 (2): 591–597.
Published: 21 December 2011
... the 1.9 Å (1 Å=0.1 nm) X-ray structure of the Cwc2 core domain, which is both necessary and sufficient for RNA binding. The Cwc2 core domain contains two sub-domains, a CCCH-type ZnF (zinc finger) and a RRM (RNA recognition motif). Unexpectedly, the ZnF domain and the RRM form a single folding unit, glued...
Includes: Supplementary data
Articles
Biochem J (2009) 424 (3): 479–490.
Published: 10 December 2009
...-L1Tc recombinant protein has at least a 16-fold higher affinity for single-stranded than for double-stranded nucleic acids, and that it exhibits a clear preference for RNA binding over DNA. The C2-L1Tc binding profile (to RNA and DNA) corresponds to a non-co-operative-binding model. The zinc fingers...
Articles
Articles
Biochem J (2007) 402 (2): 359–366.
Published: 12 February 2007
...Shih-Ming Huang; Sheng-Ping Huang; Sung-Ling Wang; Pei-Yao Liu Zac1, a novel seven-zinc-finger transcription factor, preferentially binds GC-rich DNA elements and has intrinsic transactivation activity. To date, the NLS (nuclear localization signal) of Zac1 has not been empirically determined. We...
Articles
Biochem J (2005) 386 (1): 85–91.
Published: 08 February 2005
...Rafal SWIERCZ; Maria D. PERSON; Mark T. BEDFORD PRMT3 (protein arginine methyltransferase 3) is one of four type I arginine methyltransferases that catalyse the formation of asymmetric dimethylarginine. PRMT3 is unique in that its N-terminus harbours a C 2 H 2 zinc-finger domain that is proposed...
Articles
Biochem J (2004) 381 (3): 685–691.
Published: 27 July 2004
... double minute protein (MDM2) protein secondary structure zinc finger CBP [CREB (cAMP-response-element-binding protein)-binding protein]/p300 are members of a family of transcriptional co-activators which are involved in cell growth, development, and differentiation [ 1 – 4 ]. Most...
Articles
Biochem J (2004) 381 (3): e3.
Published: 27 July 2004
.... Amann B. T. Berg J. M. Metal binding and folding properties of a minimalist Cys2His2 zinc finger peptide Proc. Natl. Acad. Sci. U.S.A. 1992 89 4796 4800 8 Falke J. J. Drake S. K. Hazard A. L. Peersen O. B. Molecular tuning of ion binding to calcium signaling...
Articles
Biochem J (2003) 370 (2): 719–727.
Published: 01 March 2003
...Robert BABB; Benjamin R. BOWEN Peroxisome-proliferator-activated receptors (PPARs), members of the nuclear hormone receptor superfamily, play an important role in the regulation of lipid metabolism and energy homoeostasis. In a yeast two-hybrid experiment using the zinc-finger transcription factor...
Articles