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Keywords: zinc
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Biochem J (2020) 477 (6): 1123–1136.
Published: 23 March 2020
...-NOX) can be easily purified in a heme-free state that is capable of reversibly responding to oxidation, suggesting a heme-independent function as a redox sensor. This occurs by oxidation of Cys residues at a zinc-binding site conserved in a subset of H-NOX homologs. Remarkably, zinc is not lost from...
Includes: Supplementary data
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Biochem J (2019) 476 (13): 1889–1909.
Published: 02 July 2019
... accumulation. We studied natural variation in grain micronutrient accumulation in barley ( Hordeum vulgare L.) and searched for candidate genes by assessing marker-trait associations (MTAs) and by analyzing transcriptional differences between low and high zinc (Zn) accumulating cultivars during grain filling...
Includes: Supplementary data
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Biochem J (2019) 476 (11): 1573–1583.
Published: 11 June 2019
...Palsa Kondaiah; Mohamad F. Aslam; Purna Chandra Mashurabad; Paul A. Sharp; Raghu Pullakhandam The absorption of iron is influenced by numerous dietary and physiological factors. We have previously demonstrated that zinc treatment of intestinal cells increases iron absorption via induction...
Includes: Supplementary data
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Biochem J (2015) 466 (3): 537–546.
Published: 06 March 2015
... underlies ROS-induced β-cell death and Zn 2+ , rather than Ca 2+ , plays a primary role in apoptosis. apoptosis calcium reactive oxygen species Type 1 diabetes transient receptor potential (melastatin) 2 (TRPM2) channels zinc Human embryonic kidney (HEK)-293 and insulin secreting (INS1...
Includes: Supplementary data
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Biochem J (2012) 443 (3): 769–778.
Published: 16 April 2012
... © The Authors Journal compilation © 2012 Biochemical Society 2012 apolipoprotein A-I amyloid-β peptide metallopeptidase transthyretin zinc TTR (transthyretin) is a plasma protein existing mainly as a homotetramer [ 1 ]. TTR is well characterized, since point mutations can cause FAP...
Includes: Supplementary data
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Biochem J (2012) 443 (1): 57–64.
Published: 14 March 2012
... (email g.rena@dundee.ac.uk ). 14 12 2011 16 1 2012 16 1 2012 Alzheimer's disease clioquinol forkhead box O1a (FOXO1a) insulin Type 2 diabetes zinc Besides its role in glucose homoeostasis, IIS [insulin/IGF-1 (insulin-like growth factor-1) signalling] components...
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Biochem J (2011) 435 (1): 259–266.
Published: 15 March 2011
...Yi-Hsuan Wu; Avery G. Frey; David J. Eide The Msc2 and Zrg17 proteins of Saccharomyces cerevisiae are members of the cation diffusion facilitator family of zinc transporters. These proteins form heteromeric complexes that transport zinc into the ER (endoplasmic reticulum). Previous studies...
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Biochem J (2010) 430 (3): 511–518.
Published: 27 August 2010
... that misfolded oligomeric intermediates occurring in the insulin fibrillation pathway, especially in zinc-deficient conditions, might induce autoantibodies against insulin, which leads to β-cell damage and autoimmune Type 1 diabetes. 1 To whom correspondence should be addressed (email peepp...
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Biochem J (2010) 427 (2): 289–296.
Published: 29 March 2010
... the binding of a range of metal ions to wild-type and mutant human and murine hepcidins. In addition, the biological effects of these point mutations were tested on Caco-2 and HEK-293T human cell lines and in mice. Our results show that hepcidin-25 can form complexes with copper, nickel and zinc; however, we...
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Biochem J (2009) 417 (1): 323–330.
Published: 12 December 2008
..., kinetics, and UV–visible, EPR, and 1 H-NMR spectroscopies. The purified enzyme was purple and contained substoichiometric amounts of iron and zinc; however, metal-binding studies reveal that GLX2-1 can bind nearly two equivalents of either iron or zinc and that the most stable analogue of GLX2-1...
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Biochem J (2009) 417 (1): 133–139.
Published: 12 December 2008
...Haijun Yu; Yunfeng Zhou; Stuart E. Lind; Wei-Qun Ding We have previously demonstrated that clioquinol (5-chloro-7-iodo-8-hydroxyquinoline) acts as a zinc ionophore and induces apoptosis of human cancer cells; however, the mechanisms of clioquinol/zinc-induced apoptotic cell death remain...
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Biochem J (2005) 392 (3): 443–448.
Published: 06 December 2005
... 2005 25 7 2005 The Biochemical Society, London 2005 betaine-homocysteine S-methyltransferase (BHMT) conformational change hydrogen peroxide (H 2 O 2 ) Met oxidative stress proteolysis zinc Betaine-homocysteine S-methyltransferase (BHMT; EC 2.1.1.5) belongs to a family...
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Biochem J (2005) 391 (2): 301–310.
Published: 10 October 2005
... Rpn10/p54 zinc The ubiquitin–proteasome system is responsible for the controlled proteolysis of intracellular proteins. The first component of this system, the ubiquitinating enzyme cascade recognizes the different degradation signals present in short-lived proteins and, by attaching...
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Biochem J (2005) 387 (2): 447–453.
Published: 05 April 2005
... by radioligand blotting, titration with a zinc (II) fluorophore chelator and NMR analysis. A chromogenic substrate was used to measure the enzymatic activity of PSA. SgI and SgII bound Zn 2+ with a stoichiometry of at least 10 mol (mol of protein) −1 and with an average dissociation constant of approx. 5 μM per...
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Biochem J (2004) 383 (1): 63–71.
Published: 24 September 2004
... have four conserved domains, C1–C4. The C1 domain contains cysteine-rich finger-like motifs, which bind two zinc atoms. The zinc-finger motifs modulate diacylglycerol binding; thus, intracellular zinc concentrations could influence the activity and localization of PKC family members. 3T3 cells were...
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Biochem J (2004) 378 (2): 579–587.
Published: 01 March 2004
...Sandra V. VERSTRAETEN; M. Paola ZAGO; Gerardo G. MACKENZIE; Carl L. KEEN; Patricia I. OTEIZA We investigated whether zinc deficiency can affect plasma membrane rheology. Three cell lines, human leukaemia T-cells (Jurkat), rat fibroblasts (3T3) and human neuroblastoma cells (IMR-32), were cultured...
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Biochem J (2003) 372 (2): 577–585.
Published: 01 June 2003
... hyperthermophilic enzyme thermostability zinc Abbreviations used: AK, adenylate kinase; BSAK, Bacillus stearothermophilus AK; DSC, differential scanning calorimetry; ECAK, Escherichia coli AK; Ec-PRAI, E. coli phosphoribosyl anthranilate isomerase; GdnHCl, guanidine hydrochloride; ICP-AES...
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Biochem J (2000) 345 (3): 621–625.
Published: 25 January 2000
... should be addressed (e-mail jesper.haeggstrom@mbb.ki.se). 8 10 1999 12 11 1999 The Biochemical Society, London © 2000 2000 aminopeptidase inflammation leukotriene B4 mutagenesis zinc Biochem. J. (2000) 345, 621 625 (Printed in Great Britain) 621 Leukotriene A4 hydrolase...
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