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Keywords: ubiquitin ligases
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Articles
Biochem J (2022) 479 (23): 2419–2431.
Published: 07 December 2022
... agreement with JISC. HOIL-1 innate immunity Toll-like receptors ubiquitin ligases ubiquitins The linear ubiquitin assembly complex (LUBAC) contains two different E3 ubiquitin ligases, HOIL-1 (haem-oxidised IRP2 ubiquitin ligase-1), also called RBCK1 (RING-B-box-coiled-coil protein...
Includes: Supplementary data
Articles
Biochem J (2022) 479 (20): 2261–2278.
Published: 28 October 2022
... patients. KSHV utilizes two viral E3 ubiquitin ligases, K3 and K5, in KSHV-infected cells to mediate the polyubiquitination-dependent down-regulation of several host membrane proteins involved in the immune system. Although K3 and K5 are members of the same family and have similar structural topologies, K3...
Includes: Supplementary data
Articles
Biochem J (2022) 479 (6): 751–766.
Published: 28 March 2022
... structure protein–protein interactions ubiquitin ubiquitin ligases Parkinson's disease (PD) affects ∼1% of the world's population [ 1 ]. Though age of onset and disease severity can vary greatly among patients, there is increasing evidence that implicates mitochondrial dysfunction as a major...
Includes: Supplementary data
Articles
Biochem J (2022) 479 (5): 661–675.
Published: 04 March 2022
... mutation protein-serine-threonine kinases ubiquitin ligases WNK (with no lysine) kinases play a key role in mammalian blood pressure regulation [ 1–3 ]. WNKs, together with their downstream targets SPAK (SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase 1...
Includes: Supplementary data
Articles
Biochem J (2022) 479 (3): 289–304.
Published: 04 February 2022
... for these modifications are therefore potential targets for therapeutic intervention. DTX3L is an E3 Ubiquitin ligase that forms a heterodimer with PARP9. In addition to its ubiquitin ligase activity, DTX3L–PARP9 also acts as an ADP-ribosyl transferase for Gly 76 on the C-terminus of ubiquitin. NAD + -dependent ADP...
Includes: Supplementary data
Articles
Biochem J (2021) 3467–3483.
Published: 30 September 2021
... 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 BARD1 BRCA1 ubiquitin ligases ubiquitin signaling ubiquitins Mutations in the BRCA1 gene were first linked to increased risk for familial breast cancer over 30 years ago [ 1–4 ]. Since...
Articles
Biochem J (2019) 476 (19): 2869–2882.
Published: 11 October 2019
... E3 ubiquitin ligase MARCH2. MARCH2 is a member of a family of membrane-bound E3 ubiquitin ligases that target cell surface receptors for degradation. MARCH2 overexpressing M1 clones retained responsiveness to the related cytokines leukemia inhibitory factor and oncostatin M and we showed that its...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (18): 3207–3226.
Published: 08 September 2017
...Shisako Shoji; Kazuharu Hanada; Noboru Ohsawa; Mikako Shirouzu Really interesting new gene (RING)-finger protein 52 (RNF52), an E3 ubiquitin ligase, is found in eukaryotes from yeast to humans. Human RNF52 is known as breast cancer type 1 susceptibility protein (BRCA1)-associated protein 2 (BRAP...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (9): 1439–1451.
Published: 13 April 2017
... disease ubiquitin ubiquitin ligases Advances in genetics have begun to unravel the molecular basis of Parkinson's through the discovery of nearly 20 genes mutated in rare familial forms of the disease. The proteins encoding these genes have been implicated in diverse cellular pathways including...
Articles
Biochem J (2017) 474 (7): 1127–1147.
Published: 15 March 2017
... The Author(s) 2017 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . chemical biology chemical tools ubiquitin ligases ubiquitin–proteasome system...
Articles
Biochem J (2017) 474 (5): 781–795.
Published: 20 February 2017
... polyubiquitination ubiquitin ligases Covalent ligation of ubiquitin to substrates and ubiquitins is achieved via a three-enzyme cascade: activation of ubiquitin by E1 ubiquitin-activating enzymes, conjugation of ubiquitin to E2-conjugating enzymes, and finally transfer of ubiquitin by E2 bound-E3 ubiquitin...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (4): 445–469.
Published: 03 February 2017
... 2016 14 12 2016 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 molecular chaperone post-translational modification proteasome protein quality control ubiquitin ligases Proteins exhibit a wide variety of structural...
Articles
Biochem J (2016) 473 (20): 3563–3580.
Published: 11 October 2016
... with alterations in red blood cell parameters. Point mutations within FBXO7 map within specific functional domains, including near its F-box domain and its substrate recruiting domains, suggesting that deficiencies in SCF Fbxo7/PARK15 ubiquitin ligase activity are mechanistically linked to early-onset PD. To date...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (16): 2453–2462.
Published: 11 August 2016
... distinct substrates and functions. axon neurites ubiquitin C-terminal hydrolase L1 (UCH-L1) ubiquitin ligases ubiquitin proteasome system Ubiquitin is a highly conserved 76-amino acid protein that can be conjugated, either singly or as polyubiquitin chains, to residues in a target protein...