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Keywords: ubiquitin ligases
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Articles
Biochem J (2023) 480 (22): 1817–1831.
Published: 17 November 2023
... residues. However, several ubiquitin ligases (E3s) have recently been identified that ubiquitylate proteins on non-Lys residues. For instance, HOIL-1 belongs to the RING-in-between RING (RBR) class of E3s and has an established role in Ser ubiquitylation. Given the homology between HOIL-1 and ARIH1, an RBR...
Includes: Supplementary data
Articles
Biochem J (2022) 479 (23): 2419–2431.
Published: 07 December 2022
... Society under a transformative agreement with JISC. HOIL-1 innate immunity Toll-like receptors ubiquitin ligases ubiquitins The linear ubiquitin assembly complex (LUBAC) contains two different E3 ubiquitin ligases, HOIL-1 (haem-oxidised IRP2 ubiquitin ligase-1), also called RBCK1 (RING-B...
Includes: Supplementary data
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Biochem J (2022) 479 (6): 751–766.
Published: 28 March 2022
... PD but mutations in two genes in particular are found in over 50% of patients: PARK2 , which encodes the ‘RBR’ E3 ubiquitin ligase parkin, and PARK6 , which encodes PTEN-induced kinase 1 (PINK1) [ 3 ]. Under oxidative stress conditions PINK1 activates parkin (pParkin), promoting the ubiquitination...
Includes: Supplementary data
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Biochem J (2022) 479 (3): 289–304.
Published: 04 February 2022
... for these modifications are therefore potential targets for therapeutic intervention. DTX3L is an E3 Ubiquitin ligase that forms a heterodimer with PARP9. In addition to its ubiquitin ligase activity, DTX3L–PARP9 also acts as an ADP-ribosyl transferase for Gly 76 on the C-terminus of ubiquitin. NAD + -dependent ADP...
Includes: Supplementary data
Articles
Biochem J (2021) 478 (18): 3467–3483.
Published: 30 September 2021
... 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 BARD1 BRCA1 ubiquitin ligases ubiquitin signaling ubiquitins Mutations in the BRCA1 gene were first linked to increased risk for familial breast cancer over 30 years ago [ 1–4 ]. Since...
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Biochem J (2017) 474 (18): 3207–3226.
Published: 08 September 2017
...Shisako Shoji; Kazuharu Hanada; Noboru Ohsawa; Mikako Shirouzu Really interesting new gene (RING)-finger protein 52 (RNF52), an E3 ubiquitin ligase, is found in eukaryotes from yeast to humans. Human RNF52 is known as breast cancer type 1 susceptibility protein (BRCA1)-associated protein 2 (BRAP...
Includes: Supplementary data
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Biochem J (2017) 474 (9): 1439–1451.
Published: 13 April 2017
... Attribution License 4.0 (CC BY) . kinase Parkinson's disease ubiquitin ubiquitin ligases Advances in genetics have begun to unravel the molecular basis of Parkinson's through the discovery of nearly 20 genes mutated in rare familial forms of the disease. The proteins encoding these genes have...
Articles
Biochem J (2017) 474 (7): 1127–1147.
Published: 15 March 2017
... through an enzymatic cascade starting with activation of ubiquitin by the E1 ubiquitin ligase enzymes (UBEs), ubiquitin-like modifier-activating enzymes (UBAs) 1 and 6. Activated ubiquitin is then transferred to a ubiquitin-conjugating enzyme E2, of which there are ∼30 examples. Subsequently, the members...
Articles
Biochem J (2017) 474 (5): 781–795.
Published: 20 February 2017
... ligation of ubiquitin to substrates and ubiquitins is achieved via a three-enzyme cascade: activation of ubiquitin by E1 ubiquitin-activating enzymes, conjugation of ubiquitin to E2-conjugating enzymes, and finally transfer of ubiquitin by E2 bound-E3 ubiquitin ligases to the substrate [ 1 – 4 ]. Covalent...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (4): 445–469.
Published: 03 February 2017
... 2016 14 12 2016 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 molecular chaperone post-translational modification proteasome protein quality control ubiquitin ligases The mammalian E3, gp78 [ 164 ], is another major E3...
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Biochem J (2016) 473 (16): 2453–2462.
Published: 11 August 2016
... structure can provide new insights into its roles in neuronal function and pathology. axon neurites ubiquitin C-terminal hydrolase L1 (UCH-L1) ubiquitin ligases ubiquitin proteasome system The identification and safe destruction of unwanted, misfolded or aggregated proteins is essential...