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Keywords: transcription factors
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Articles
Biochem J (2023) 480 (5): 385–401.
Published: 15 March 2023
... of the sex determination cascade is most conserved. They belong to the Doublesex/mab-3 -related ( Dmrt ) gene family including Doublesex ( Dsx ) in arthropods [ 3 ], mab-3 ( male abnormality 3 ) in nematodes [ 4 ] and Dmrt1 ( Dsx and mab-3-related transcription factor 1 ) in mammals and other...
Includes: Supplementary data
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Biochem J (2022) 479 (23): 2395–2417.
Published: 07 December 2022
... receptor signalling to control cell growth and survival and suppress lytic replication. Here, we show that the EBV transcription factors EBNA2, 3A, 3B and 3C bind to genomic sites around multiple B cell receptor (BCR) pathway genes, regulate their expression and affect BCR signalling. EBNA2 regulates...
Includes: Supplementary data
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Biochem J (2022) 479 (13): 1441–1454.
Published: 13 July 2022
...Emily L. Button; Joseph J. Rossi; Daniel P. McDougal; John B. Bruning; Daniel J. Peet; David C. Bersten; Jill A. Rosenfeld; Murray L. Whitelaw Single-minded 2 (SIM2) is a neuron-enriched basic Helix–Loop–Helix/PER–ARNT–SIM (bHLH/PAS) transcription factor essential for mammalian survival. SIM2...
Includes: Supplementary data
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Biochem J (2022) 479 (2): 161–183.
Published: 28 January 2022
... ACE2 expression in human vascular endothelial cells in an NF-κB-dependent manner. The NF-κB transcription factor constitutes a homo- or heterodimeric protein that binds to a 5'-GGGRNNNYCC-3’ (where G, C, R, Y, and N are guanine, cytosine, purine, pyrimidine, and any nucleotide base, respectively...
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Biochem J (2021) 478 (20): 3741–3756.
Published: 21 October 2021
...Monali NandyMazumdar; Alekh Paranjapye; James Browne; Shiyi Yin; Shih-Hsing Leir; Ann Harris The cystic fibrosis transmembrane conductance regulator ( CFTR ) gene lies within a topologically associated domain (TAD) in which multiple cis -regulatory elements (CREs) and transcription factors (TFs...
Includes: Supplementary data
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Biochem J (2021) 478 (17): 3297–3317.
Published: 14 September 2021
... in reducing the severity of both the diseases. The study demonstrates that the abundance of Grb2 in degenerative conditions, in conjunction with NOX4, reverse cytoskeletal degradation by counterbalancing the network of small GTPases. PAX4, a transcription factor for both Grb2 and NOX4, emerges as the key link...
Includes: Supplementary data
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Biochem J (2019) 476 (19): 2757–2767.
Published: 11 October 2019
...Sowmya P. Lakshmi; Aravind T. Reddy; Asoka Banno; Raju C. Reddy Nur77 is a transcription factor belonging to the NR4A subfamily of nuclear hormone receptors. Upon induction, Nur77 modulates the expression of its target genes and controls a variety of biological and pathophysiological processes...
Includes: Multimedia, Supplementary data
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Biochem J (2018) 475 (2): 441–454.
Published: 31 January 2018
... and spacing, enabling efficient gas exchange. The cellular patterning process is regulated by a complex signalling pathway involving extracellular ligand–receptor interactions, which, in turn, modulate the activity of three master transcription factors essential for the formation of stomata. Here, we review...
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Biochem J (2017) 474 (9): 1509–1528.
Published: 19 April 2017
...–protein interactions proteolysis transcription factors 293HEK cells plated on fibronectin-coated coverslips were transfected with expression plasmids using LipofectAMINE 2000 and coverslips were processed 48 h after transfection. Coverslips were washed in PBS, fixed in 4% paraformaldehyde...
Includes: Supplementary data
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Biochem J (2005) 392 (1): 181–189.
Published: 08 November 2005
...Wataru Nishimura; Therese Salameh; Takuma Kondo; Arun Sharma The transcription factor MafA/RIPE3b1 is an important regulator of insulin gene expression. MafA binds to the insulin enhancer element RIPE3b (C1-A2), now designated as insulin MARE (Maf response element). The insulin MARE element shares...
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Biochem J (2003) 372 (3): 831–839.
Published: 15 June 2003
...Elisabetta LAMBERTINI; Letizia PENOLAZZI; Silvia GIORDANO; Laura DEL SENNO; Roberta PIVA (O)estrogen receptor-α (ERα), a hormone-dependent transcription factor belonging to the steroid/thyroid-hormone-receptor superfamily, plays an essential role in the development and maintenance of the skeleton...
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Biochem J (2002) 365 (3): 561–575.
Published: 01 August 2002
...Dipak P. RAMJI; Pelagia FOKA CCAAT/enhancer binding proteins (C/EBPs) are a family of transcription factors that all contain a highly conserved, basic-leucine zipper domain at the C-terminus that is involved in dimerization and DNA binding. At least six members of the family have been isolated...
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Biochem J (2002) 363 (1): 53–58.
Published: 22 March 2002
... promoters without binding directly to the target DNA. 1 To whom correspondence should be addressed (e-mail fsc@unicz.it ). 11 7 2001 5 12 2001 29 1 2002 The Biochemical Society, London ©2002 2002 CBP/p300 nuclear factor Y transcription factors Abbreviations used...
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Biochem J (2001) 360 (2): 321–333.
Published: 26 November 2001
...Claire JOSSE; Johan R. BOELAERT; Martin BEST-BELPOMME; Jacques PIETTE The transcription factor, nuclear factor κB (NF-κB), is activated by various stimuli including cytokines, radiation, viruses and oxidative stress. Here we show that, although induction with H 2 O 2 gives rise to NF-κB nuclear...
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Biochem J (2001) 360 (2): 285–294.
Published: 26 November 2001
...Eliana M. COCCIA; Emilia STELLACCI; Mauro VALTIERI; Barbara MASELLA; Tiziana FECCIA; Giovanna MARZIALI; John HISCOTT; Ugo TESTA; Cesare PESCHLE; Angela BATTISTINI Numerous transcription factors allow haematopoietic cells to respond to lineage- and stage-specific cytokines and to act...
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Biochem J (2000) 346 (2): 529–535.
Published: 22 February 2000
... in transgenic mice that the tissue-specific and developmental expression of lactase is controlled by a 1 kb upstream region of the pig lactase gene. Two homeodomain transcription factors, caudal-related homeodomain protein (Cdx2) and hepatic nuclear factor 1α (HNF1α), are known to bind to regulatory cis...
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Biochem J (1999) 341 (2): 315–322.
Published: 08 July 1999
... transcription factors Biochem. J. (1999) 341, 315 322 (Printed in Great Britain) 315 Upstream stimulatory factor regulates Pdx-1 gene expression in differentiated pancreatic b-cells Jin QIAN*, Elizabeth N. KAYTOR‹1, Howard C. TOWLE‹ and L. Karl OLSON*2 *Department of Physiology, Michigan State University...
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Biochem J (1999) 338 (3): 607–613.
Published: 08 March 1999
..., France (e-mail Mojgan.Mergny@curie.fr ). 17 9 1998 3 12 1998 22 12 1998 The Biochemical Society, London © 1999 1999 oxidative stress skin transcription factors UV radiation Biochem. J. (1999) 338, 607 613 (Printed in Great Britain) 607 UV-A-induced decrease in nuclear...
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Biochem J (1999) 338 (1): 91–97.
Published: 08 February 1999
...Roger H. ERICKSON; James R. GUM; Craig D. LOTTERMAN; James W. HICKS; Roy S. LAI; Young S. KIM Hepatocyte nuclear factor 1 was identified as the transcription factor binding to a 20 bp (-150 to -131) region of the gene for human dipeptidyl peptidase IV, which has been shown to be important...