1-50 of 161
Keywords: transcription
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles
Biochem J (2023) 480 (5): 297–306.
Published: 09 March 2023
...Josef Houser; Kristina Jendruchova; Andrea Knight; Martin Piskacek The nine-amino-acid transactivation domains (9aaTAD) was identified in numerous transcription factors including Gal4, p53, E2A, MLL, c-Myc, N-Myc, and also in SP, KLF, and SOX families. Most of the 9aaTAD domains interact...
Includes: Supplementary data
Articles
Biochem J (2022) 479 (11): 1205–1220.
Published: 13 June 2022
... are unknown but could be identified by testing the expression of NUCKS1 deletion constructs in NUCKS1 knockout cells. Moreover, RAD51AP1 drives HR in transcriptionally active regions of the genome [ 118 ], and this may also be the case for NUCKS1. NUCKS1 does not have a transcription activation site...
Articles
Biochem J (2022) 479 (6): 767–786.
Published: 28 March 2022
... in chromatin accessibility responses across cell types, which may be linked to transcriptional responses. It has been suggested that basal gene expression profiles define, at least in part, cell type specific transitional responses to hypoxia, with genes transcriptionally active prior to hypoxia stimulation...
Includes: Supplementary data
Articles
Biochem J (2021) 478 (6): 1261–1282.
Published: 19 March 2021
...Diti Chatterjee Bhowmick; Lydia Burnett; Zhanar Kudaibergenova; Aleksandar M. Jeremic Here, we investigated transcriptional and trafficking mechanisms of human islet amyloid polypeptide (hIAPP) in normal and stressed β-cells. In high glucose-challenged human islets and rat insulinoma cells...
Includes: Multimedia, Supplementary data
Articles
Articles
In Collection
Adipose biology
Biochem J (2020) 477 (6): 1137–1148.
Published: 27 March 2020
.... The recent recognition of the presence of brown or beige adipocytes in human adults has attracted much attention to elucidate the molecular mechanism underlying the thermogenic adipose program. Many key transcriptional regulators critical for the thermogenic gene program centering on activating the UCP1...
Articles
Articles
Biochem J (2018) 475 (12): 2073–2090.
Published: 29 June 2018
...John Biddlestone; Michael Batie; Daniel Bandarra; Ivan Munoz; Sonia Rocha The SIN3A–HDAC (histone deacetylase) complex is a master transcriptional repressor, required for development but often deregulated in disease. Here, we report that the recently identified new component of this complex...
Includes: Supplementary data
Articles
Biochem J (2018) 475 (6): 1059–1062.
Published: 20 March 2018
... transcription of the HIV-1 LTR promoter [ 3 ]. Tat is encoded by two exons where exon 1 contributes the first 72 residues of a full-length protein made of 86–104 amino acids, depending on the viral isolate. The truncated 72 amino acid version of Tat is transcriptionally competent and has two main domains...
Articles
Biochem J (2016) 473 (21): 3741–3753.
Published: 27 October 2016
...Nan Zhang; Vidya C. Darbari; Robert Glyde; Xiaodong Zhang; Martin Buck Transcription initiation is highly regulated in bacterial cells, allowing adaptive gene regulation in response to environment cues. One class of promoter specificity factor called sigma54 enables such adaptive gene expression...
Articles
Articles
Biochem J (2016) 473 (19): 3065–3079.
Published: 27 September 2016
...M. Gomar-Alba; M. del Olmo Hyperosmotic stress response involves the adaptative mechanisms needed for cell survival. Under high osmolarity conditions, many stress response genes are activated by several unrelated transcription factors that are controlled by the Hog1 kinase. Osmostress transcription...
Includes: Supplementary data
Articles
Biochem J (2015) 469 (3): 391–398.
Published: 23 July 2015
...Beiying Qiu; Xiaohe Shi; Qiling Zhou; Hui Shan Chen; Joy Lim; Weiping Han; Vinay Tergaonkar Nuclear ubiquitous casein and cyclin-dependent kinase substrate (NUCKS) is highly expressed in the brain and peripheral metabolic organs, and regulates transcription of a number of genes involved in insulin...
Articles
Biochem J (2015) 466 (3): 587–599.
Published: 06 March 2015
... methyltransferase4 (PRMT4), is a type I PRMT that asymmetrically dimethylates arginine on target proteins. CARM1 was first identified as an interacting partner of the glucocorticoid receptor interacting protein 1 (GRIP1) co-activator protein that enhanced transcriptional activity of several steroid hormone receptors...
Includes: Supplementary data
Articles
Biochem J (2014) 462 (3): 385–395.
Published: 22 August 2014
... that gene expression is co-ordinated by changes in transcription and translation in hypoxia, much less is known about how chromatin changes allow for transcription to take place. The missing link between co-ordinating chromatin structure and the hypoxia-induced transcriptional programme could be in the form...
Articles
Biochem J (2014) 462 (2): 373–384.
Published: 07 August 2014
... van der Oost MBF1 (multi-protein bridging factor 1) is a protein containing a conserved HTH (helix–turn–helix) domain in both eukaryotes and archaea. Eukaryotic MBF1 has been reported to function as a transcriptional co-activator that physically bridges transcription regulators with the core...
Includes: Supplementary data
Articles
Biochem J (2014) 461 (1): 15–32.
Published: 13 June 2014
... for WT1 in RNA metabolism, the physiological relevance of a post-transcriptional role of WT1 remains to be confirmed. Of note, a study determined that WT1+KTS, but not WT1−KTS, up-regulated Mash1 [also known as Ascl1 (achaete–scute complex homologue 1)] mRNA and protein post-transcriptionally [ 5...
Articles
Biochem J (2014) 458 (1): 153–158.
Published: 20 January 2014
..., but not at the nucleosome dyad. We show further that in vivo TALEs bind to transcriptionally repressed chromatin and that transcription increases binding by only 2-fold. These data therefore imply that TALEs are likely to bind to their target in vivo even at inactive loci. 1 These authors contributed equally...
Includes: Supplementary data
Articles
Biochem J (2014) 457 (3): 401–413.
Published: 10 January 2014
...Maja Milanovic; Michael Kracht; M. Lienhard Schmitz The transcription factor NF-κB (nuclear factor κB) serves to up-regulate gene expression in response to precarious signals such as the pro-inflammatory cytokines TNF (tumour necrosis factor) and IL-1 (interleukin 1). In the present study we show...
Includes: Supplementary data
Articles
Biochem J (2014) 457 (2): 231–242.
Published: 20 December 2013
... predominantly during transcription, accumulating evidence suggests that cap-like structures can be also formed post-transcriptionally [ 14 ]. Figure 2 7mG synthesis in S. cerevisiae , Schizosaccharomyces pombe and humans The RNA triphosphatase enzymes are depicted in light blue, the RNA...
Articles
Biochem J (2013) 456 (1): 55–66.
Published: 24 October 2013
...Shuliang Chen; Ke Chen; Qinghua Zhang; Hanhua Cheng; Rongjia Zhou Loss and/or inactivation of the VHL (von Hippel–Lindau) tumour suppressor causes various tumours. Using a yeast two-hybrid system, we have identified the AR (androgen receptor) co-activator UXT (ubiquitously expressed transcript...
Includes: Supplementary data
Articles
Articles
Biochem J (2013) 452 (2): 321–329.
Published: 10 May 2013
... p53 stress transcription HSF1 (heat-shock factor 1) is transcriptionally activated by cells in response to a variety of extrinsic and intrinsic stresses, including heat shock, oxidative stress, nutrient deprivation and oncogene activation [ 1 ]. Its activation results in the expression...
Articles
Biochem J (2013) 449 (3): 707–717.
Published: 09 January 2013
... docking site (Mf2 domain) in an intrinsically disordered domain of IRF-1 [IFN (interferon) regulatory factor-1], a short-lived IFNγ-regulated transcription factor, in ubiquitination of the protein. Ubiquitin modification of full-length IRF-1 by E3 ligases such as CHIP [C-terminus of the Hsc (heat-shock...
Includes: Supplementary data
Articles
Biochem J (2012) 443 (3): 757–768.
Published: 16 April 2012
... [SRE (sterol-regulatory element)-binding protein 2] that activates PCSK9 gene transcription through an SRE motif of the promoter. In addition to SREBP2, HNF1α (hepatic nuclear factor 1α) positively regulates PCSK9 gene transcription in hepatic cells through a binding site located 28 bp upstream from...
Includes: Supplementary data
Articles
Biochem J (2012) 441 (1): 481–485.
Published: 14 December 2011
...María-Antonia Sánchez-Romero; David J. Lee; Eugenio Sánchez-Morán; Stephen J. W. Busby In the present paper, we report that transcription affects the location of a DNA target in Escherichia coli K-12. A strain whose chromosome had been engineered to encode a lac repressor–GFP (green fluorescent...
Articles
Biochem J (2012) 441 (1): 61–76.
Published: 14 December 2011
...) mRNA levels [ 81 ]. Although these transcript level changes suggest that 1,25(OH) 2 D induces apoptosis by transcriptionally activating or repressing various genes, such direct regulation has not yet been reported for most of these genes. In the past decade 1,25(OH) 2 D has been shown...
Articles
Biochem J (2011) 439 (3): 487–502.
Published: 13 October 2011
...Jin Zhao; Wee Leng Siew; Weiqi Sun; Norbert Lehming The nucleosomes occupying the chromosomal start sites of transcription contain the histone H2A variant H2A.Z in place of H2A. Upon galactose induction, nucleosomes are evicted from the GAL1 locus in Saccharomyces cerevisiae cells. H2A.Z (which...
Includes: Supplementary data
Articles
Biochem J (2011) 437 (3): 555–564.
Published: 13 July 2011
... that CD82, which was transcriptionally regulated by KAT5, might be a candidate effector of cell invasion promoted by PLU1. The present study demonstrated a functional contribution of PLU1 overexpression with concomitant epigenetic dysregulation in cancer progression. 22 2 2011 28 4 2011 16 5...
Includes: Supplementary data
Articles
Biochem J (2011) 435 (3): 641–649.
Published: 13 April 2011
... reports about the functional role of the degradation of transcriptional activators and indicate that gene expression studies interfering with proteasome degradation should take the stabilization of potential repressors into account. The SKP1 gene of the S. cerevisiae strain JD52 [ 23...
Includes: Supplementary data
Articles
Biochem J (2011) 435 (2): 489–498.
Published: 29 March 2011
... cannot be differentiated between and are thus referred to as SUMO2/3. Whether these two isoforms are regulated in distinct manners has never been addressed. In the present paper we report that the expression of SUMO3, but not SUMO2, can be down-regulated at the transcription level by cellular oxidative...
Includes: Supplementary data
Articles
Biochem J (2011) 435 (1): 247–257.
Published: 15 March 2011
... wild-type β-catenin or constitutively active β-catenin S37A abrogated β-catenin-induced axis duplication and attenuated β-catenin-stimulated reporter transcription. Lastly, we provide evidence that Xrel3, but not XrelA, can interact with β-catenin without affecting the association of β-catenin...
Articles
Biochem J (2011) 435 (1): 259–266.
Published: 15 March 2011
... suggested that the ZRG17 gene is regulated in response to zinc status by the Zap1 transcription factor. Zap1 activates the expression of many genes in zinc-deficient cells. In the present study, we assessed whether ZRG17 is a direct Zap1 target gene. We showed that ZRG17 mRNA levels were elevated in zinc...
Articles
Biochem J (2011) 434 (1): 83–92.
Published: 27 January 2011
... / BAF250b that are unique to the BAF complex and absent in the related PBAF (Polybromo BAF). hOsa / BAF250 has been shown to interact with transcriptional activators and bind to DNA suggesting that it acts to target the remodelling complex to chromatin. To better understand the functions of hOsa2, we...
Articles
Articles
Biochem J (2010) 432 (3): 473–486.
Published: 25 November 2010
... synthesis, adrenal and gonadal development and sex differentiation by co-activating SF-1. gene expression luteinizing hormone pituitary steroidogenesis transcription PGC-1α [PPARγ (peroxisome-proliferator-activated receptor γ) co-activator 1α] is a member of a family of transcription...
Includes: Supplementary data
Articles
Biochem J (2010) 431 (2): 179–187.
Published: 28 September 2010
...Eun-Jung Park; Shin-Kyoung Hur; Jongbum Kwon Recent studies have shown that the SWI/SNF family of ATP-dependent chromatin-remodelling complexes play important roles in DNA repair as well as in transcription. The INO80 complex, the most recently described member of this family, has been shown...
Articles
Biochem J (2010) 430 (1): 107–117.
Published: 28 July 2010
.... These results suggest that appropriate control of NEU3 gene expression is required for homoeostasis of cellular functions. To gain insights into regulation mechanisms, we determined the gene structure and assessed transcription factor involvement. Oligo-capping analysis indicated the existence of alternative...
Includes: Supplementary data
Articles
Biochem J (2010) 428 (2): 247–254.
Published: 13 May 2010
... to be elicited. This dynamism is controlled by two competing conjugating and deconjugating activities. The latter activity is mediated by the SENP [SUMO1/sentrin/SMT3 (suppressor of mif two 3 homologue 1)-specific peptidase] family of SUMO-specific proteases. The transcription factor Elk-1 [ETS (E twenty-six...
Articles
Biochem J (2010) 427 (3): 541–550.
Published: 14 April 2010
...-hypersensitive site mapping. Gel-shift assays and chromatin immunoprecipitation of the core region of a hypersensitive site 4.4 kb upstream of BCL6 transcription initiation (HSS-4.4) showed an E-box element-binding ZEB1 (zinc finger E-boxbinding homeobox 1) and the co-repressor CtBP (C-terminal binding protein...
Includes: Supplementary data
Articles
Articles
Biochem J (2010) 425 (2): 295–302.
Published: 23 December 2009
... that pools of mRNAs are present in the cell which are unmethylated on the guanosine cap. If cap methylation can only occur at the initiation of transcription, then such unmethylated mRNAs will be weakly translated until degraded. If, however, mRNA cap methylation could be regulated post-transcriptionally...
Articles
Biochem J (2010) 425 (1): 215–224.
Published: 14 December 2009
...Victoria A. Payne; Wo-Shing Au; Christopher E. Lowe; Shaikh M. Rahman; Jacob E. Friedman; Stephen O'Rahilly; Justin J. Rochford The transcription factor SREBP1c (sterol-regulatory-element-binding protein 1c) is highly expressed in adipose tissue and plays a central role in several aspects...
Includes: Supplementary data
Articles
Biochem J (2009) 422 (3): 543–551.
Published: 27 August 2009
...Hanshao Liu; Hoi Chin Hew; Zheng-Guang Lu; Tomoko Yamaguchi; Yoshio Miki; Kiyotsugu Yoshida Transcriptional regulation of the p53 tumour suppressor gene plays an important role in the control of the expression of various target genes involved in the DNA damage response. However, the molecular basis...
Articles
Articles
Articles
Biochem J (2009) 422 (2): 363–372.
Published: 13 August 2009
... previous work showed that S100A9 was severely down-regulated in human ESCC (oesophageal squamous cell carcinoma). To further investigate the transcriptional regulation of S100A9, we analysed the S100A9 promoter region and found several putative p53BS (p53-binding sites). Luciferase reporter assays showed...
Includes: Supplementary data
Articles
Articles
Biochem J (2009) 420 (3): 421–428.
Published: 27 May 2009
...Wen Tang; Wanhui You; Feng Shi; Tianyang Qi; Ling Wang; Zina Djouder; Wenguang Liu; Xianlu Zeng Actin, the major component of the cytoplasmic skeleton, has been shown to exist in the nucleus. Nuclear actin functions in several steps of the transcription process, including chromatin remodelling...
Articles
Biochem J (2009) 419 (1): 167–176.
Published: 13 March 2009
...Moritz Hentschke; Ute Süsens; Uwe Borgmeyer Modification with SUMOs (small ubiquitin-related modifiers) has emerged as an important means of regulating the activity of transcription factors, often by repressing their activity. The ERRγ [oestrogen receptor-related receptor γ; ERR3 or NR3B3 (nuclear...