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Keywords: trafficking
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Biochem J (2022) 479 (3): 273–288.
Published: 04 February 2022
... the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . membrane fusion snare proteins trafficking Eukaryotic cells are compartmentalized into membrane-enclosed organelles. Since lipid bilayers form a hydrophobic barrier for all hydrophilic metabolites and macromolecules, compartments...
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Biochem J (2021) 478 (6): 1261–1282.
Published: 19 March 2021
...Diti Chatterjee Bhowmick; Lydia Burnett; Zhanar Kudaibergenova; Aleksandar M. Jeremic Here, we investigated transcriptional and trafficking mechanisms of human islet amyloid polypeptide (hIAPP) in normal and stressed β-cells. In high glucose-challenged human islets and rat insulinoma cells...
Includes: Multimedia, Supplementary data
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Biochem J (2020) 477 (12): 2327–2345.
Published: 26 June 2020
... for this article was enabled by the participation of University College London in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. Clahtrin-independent endocytosis endophilin FEME trafficking Cell surface...
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Biochem J (2020) 477 (8): 1363–1366.
Published: 23 April 2020
... 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cancer cell penetrating peptide lipid microdomains membranes therapeutics trafficking In a recent issue of this journal Eissa et al. highlight a novel membrane-active...
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Biochem J (2019) 476 (23): 3583–3593.
Published: 03 December 2019
... insulin-like growth factor receptors trafficking Filopodia are thin membrane protrusions of 100 to 200 nm diameter, containing 10–30 actin filaments bundled together by actin cross-linking proteins [ 1 , 2 ]. The structure of filopodia is established dynamically: F-actin in filopodia undergoes...
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Biochem J (2019) 476 (1): 25–37.
Published: 07 January 2019
... Mitochondrial and extra-mitochondrial functions and locations of dual localised proteins are described. Both nuclear and mitochondrially encoded proteins are included. Species and relevant references are cited. cellular localisation mitochondria mtDNA multifunctional proteins trafficking...
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Biochem J (2017) 474 (24): 4105–4118.
Published: 06 December 2017
...). Published by Portland Press Limited on behalf of the Biochemical Society 2017 insulin-like growth factor receptor tyrosine kinases trafficking turnover Ubiquilin IGF1R (insulin-like growth factor-1 receptor) is a receptor tyrosine kinase ubiquitously expressed on cell surfaces of all...
Includes: Supplementary data
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Biochem J (2017) 474 (21): 3615–3626.
Published: 23 October 2017
... ). lysosomes SNARE proteins tethering complexes trafficking Eukaryotic cells exert tight control over the fusion of their membrane-bound compartments. SNARE-mediated membrane fusion events are regulated by multiple proteins [ 1 , 2 ], including multisubunit membrane tethering complexes. The class C...
Includes: Supplementary data
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Biochem J (2016) 473 (3): 233–244.
Published: 25 January 2016
...-terminal disulfide loop of the helper subunit are key elements for biogenesis of system b 0,+ . cystinuria endoplasmic reticulum folding N-linked glycosylation trafficking transporter System b 0,+ mediates re-absorption of cystine and dibasic amino acids by exchange for neutral amino...
Includes: Supplementary data
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Biochem J (2015) 472 (3): e27–e30.
Published: 27 November 2015
... Purinergic Signal. 2012 8 81 90 10.1007/s11302-011-9263-6 21987098 18 Kochukov M.Y. Ritchie A.K. A P2X7 receptor stimulates plasma membrane trafficking in the FRTL rat thyrocyte cell line Am. J. Physiol. Cell Physiol. 2004 287 C992 C1002 10.1152/ajpcell.00538.2003 15189815...
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Biochem J (2015) 470 (3): 319–330.
Published: 04 September 2015
...). This novel finding raises important considerations with regards to Panx1 surface stability in diverse scenarios in which ATP can be rapidly elevated in the extracellular space. adenosine 5′-triphosphate (ATP) endocytosis endosomes pannexin 1 pannexin1 trafficking Six individual pannexin 1...
Includes: Multimedia, Supplementary data
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Biochem J (2015) 465 (3): 471–477.
Published: 22 January 2015
... promotes surface expression of AMPA receptors; however, how TARP γ-8 regulates the expression of AMPA receptors remains unclear. In the present study, we examined the effect of TARP glycosylation on AMPA receptor trafficking. We first showed that TARP γ-8 is an N-glycosylated protein, which contains two...
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Biochem J (2014) 464 (1): 145–156.
Published: 23 October 2014
..., although the downstream substrates mediating this function are not yet clear. In the present paper, we report the lipid kinase phosphatidylinositol 4-kinase II α (PI4KIIα) is a novel substrate of GSK3 that regulates trafficking and cell-surface expression of neurotransmitter receptors in neurons. GSK3...
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Biochem J (2014) 463 (3): 339–349.
Published: 10 October 2014
... with dynamitin, a member of the microtubule-associated dynactin complex whose disruption affects the channel cell-surface density. dynactin Na v 1.5 protein complex sodium channel trafficking The voltage-gated sodium channel Na v 1.5 is responsible for action potential generation...
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Biochem J (2014) 458 (3): 513–523.
Published: 28 February 2014
... substrates. alternative splicing aminoacylation aminoacyl-tRNA synthetase apicoplast Apicomplexa dual-targeted Plasmodium Toxoplasma gondii trafficking tRNA aaRSs (aminoacyl-tRNA synthetases) are essential for protein translation and ensure the fidelity of translation from nucleic...
Includes: Multimedia, Supplementary data
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Biochem J (2013) 453 (1): 147–151.
Published: 13 June 2013
...://robetta.bakerlab.org/ ). calcium endosome lysosome nicotinic acid–adenine dinucleotide phosphate (NAADP) two-pore segment channel 1 (TPCN1) trafficking NAADP (nicotinic acid–adenine dinucleotide phosphate) is a potent and widespread Ca 2+ -mobilizing messenger [ 1 ]. It regulates processes...
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Biochem J (2012) 445 (1): 101–111.
Published: 15 June 2012
... monomers. Although this cysteine seems not to be involved in regulation of trafficking to the plasma membrane, activity, substrate selectivity or oxidative gating of ZmPIP1s (Zm is Zea mays ), ZmPIP2s and hetero-oligomers, it increases oligomer stability under denaturating conditions. In addition, when...
Includes: Supplementary data
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Biochem J (2012) 442 (2): 335–343.
Published: 13 February 2012
... from HemW in vitro . On the basis of these findings, we propose a role of HemW in haem trafficking. HemW-like proteins form a distinct phylogenetic clade that has not previously been recognized. Lactococcus lactis is a Gram-positive bacterium that is devoid of a haem biosynthetic pathway...
Includes: Supplementary data
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Biochem J (2011) 435 (2): 509–518.
Published: 29 March 2011
... should be addressed (email histo6@post.tau.ac.il ). 16 11 2010 20 1 2011 3 2 2011 3 2 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 endoplasmic reticulum post-translational modification signalling trafficking ubiquitin vesicular stomatitis...
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Biochem J (2010) 426 (3): 379–388.
Published: 24 February 2010
... heterodimers. Therefore the patient carries one kAE1 mutant that is retained in the Golgi (G701D) and another kAE1 mutant (C479W) located in the endoplasmic reticulum of kidney cells, and is thus probably unable to reabsorb bicarbonate into the blood. We conclude that the C479W mutant is a novel trafficking...
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Biochem J (2010) 425 (1): 195–208.
Published: 14 December 2009
... reticulum oxidoreductase protein disulfide isomerase (PDI) thioredoxin thioredoxin-like transmembrane protein 4 (TMX4) trafficking Amino acid sequences of TMX and TMX4 from various organisms were obtained from the Ensembl Genome Browser ( http://www.ensembl.org/index.html ). Full-length...
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Biochem J (2009) 418 (1): 163–172.
Published: 28 January 2009
... mutant failed to co-localize with Rab11 and recycle to the plasma membrane, in contrast with the wild-type receptor. To our knowledge, the present study is the first report of a direct interaction between the β2AR and a Rab GTPase, which is required for the accurate intracellular trafficking...
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Biochem J (2008) 410 (3): 585–594.
Published: 27 February 2008
...Kathryn A. Stern; Trenton L. Place; Nancy L. Lill EGF-R [EGF (epidermal growth factor) receptor] ligands can promote or inhibit cell growth. The biological outcome of receptor activation is dictated, at least in part, by ligand-specified patterns of endocytic trafficking. EGF-R trafficking...
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Biochem J (2008) 410 (3): 463–472.
Published: 27 February 2008
... manner in living cells and propose that ACBP may be involved in vesicular trafficking. 1 To whom correspondence should be addressed (email jkk@bmb.sdu.dk ). 25 4 2007 4 10 2007 22 10 2007 22 10 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008...
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Biochem J (2008) 409 (2): 555–562.
Published: 21 December 2007
... GPI-anchored proteins are targeted from the ER to the PM. In the present study, we investigated mechanisms underlying membrane trafficking of the GPI-anchored proteins, focusing on the early secretory pathway. We first established a cell line that stably expresses inducible temperature-sensitive GPI...
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Biochem J (2007) 407 (2): 171–177.
Published: 25 September 2007
...@health.missouri.edu ). 23 4 2007 18 7 2007 25 7 2007 25 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 furin MT1-MMP (membrane-type 1 matrix metalloproteinase) α1-PI (α1-proteinase inhibitor) trafficking MMPs (matrix metalloproteinases...
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Biochem J (2007) 406 (1): 157–165.
Published: 26 July 2007
...) trafficking Since the discovery of IQ (ilimaquinone)'s role in Golgi fragmentation [ 1 ], a wide variety of new vesicle trafficking regulatory proteins have been found and their cellular localization and physical interactions described, which led to the understanding of how the pathway involving...
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Biochem J (2007) 404 (3): 525–534.
Published: 29 May 2007
... the sorting of VAMP2 to vesicles before surface delivery, without influencing VAMP2 endocytosis. Consistent with this, dynamin and α-SNAP (soluble N -ethylmaleimide-sensitive fusion protein-attachment protein) mutants which block trafficking at the plasma membrane do not abrogate the effect of synaptophysin I...
Includes: Supplementary data
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Biochem J (2005) 392 (3): 475–483.
Published: 06 December 2005
... trafficking RNA containing the c- myc 3′UTR nt 194–280 (MW or MM version) or the c- fos 3′UTR 144 nt region implicated in localization [ 7 ] was purified on an 8% polyacrylamide gel in 7 M urea. Full-size RNA was eluted from the gel in 0.5 M ammonium acetate, 1 M EDTA, 0.1% (w/v) SDS in a diethyl...
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Biochem J (2000) 350 (2): 337–352.
Published: 23 August 2000
... reference to the genetic and biochemical insights provided by study of the yeast Saccharomyces cerevisiae . 1 To whom correspondence should be addressed. The Biochemical Society, London © 2000 2000 actin endocytosis exocytosis phosphoinositide trafficking Biochem. J. (2000) 350, 337...
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Biochem J (2000) 349 (1): 51–57.
Published: 26 June 2000
...-mannose to a complex oligosaccharide with a half-time of approx. 4 h, which reflected the time course of trafficking of AE1 from the endoplasmic reticulum to the plasma membrane. The turnover of the complex form of the N555 mutant occurred with a half-life of approx. 15 h. The results show...