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Keywords: trafficking
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Articles
Biochem J (2022) 479 (3): 273–288.
Published: 04 February 2022
... the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . membrane fusion snare proteins trafficking Eukaryotic cells are compartmentalized into membrane-enclosed organelles. Since lipid bilayers form a hydrophobic barrier for all hydrophilic metabolites and macromolecules, compartments...
Articles
Biochem J (2021) 478 (6): 1261–1282.
Published: 19 March 2021
...Diti Chatterjee Bhowmick; Lydia Burnett; Zhanar Kudaibergenova; Aleksandar M. Jeremic Here, we investigated transcriptional and trafficking mechanisms of human islet amyloid polypeptide (hIAPP) in normal and stressed β-cells. In high glucose-challenged human islets and rat insulinoma cells...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2020) 477 (12): 2327–2345.
Published: 26 June 2020
... access for this article was enabled by the participation of University College London in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. Clahtrin-independent endocytosis endophilin FEME trafficking...
Articles
Biochem J (2020) 477 (8): 1363–1366.
Published: 23 April 2020
... 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cancer cell penetrating peptide lipid microdomains membranes therapeutics trafficking In a recent issue of this journal Eissa et al. highlight a novel membrane-active...
Articles
Biochem J (2019) 476 (23): 3583–3593.
Published: 03 December 2019
... insulin-like growth factor receptors trafficking Filopodia are thin membrane protrusions of 100 to 200 nm diameter, containing 10–30 actin filaments bundled together by actin cross-linking proteins [ 1 , 2 ]. The structure of filopodia is established dynamically: F-actin in filopodia undergoes...
Includes: Supplementary data
Articles
Biochem J (2019) 476 (1): 25–37.
Published: 07 January 2019
... proteins trafficking transport Historically, mitochondria have been perceived almost exclusively as the cell's energy generator, principally responsible for cellular ATP (adenosine triphosphate) production, as well as an evolutionary curiosity due to their endosymbiotic nature and α...
Articles
Biochem J (2018) 475 (9): 1669–1685.
Published: 15 May 2018
...: Gustavo A. Chiabrando ( gustavo.chiabrando@unc.edu.ar ) 23 11 2017 16 4 2018 17 4 2018 18 4 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 endocytosis GTPases intracellular signaling membranes trafficking...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (24): 4105–4118.
Published: 06 December 2017
... by Portland Press Limited on behalf of the Biochemical Society 2017 insulin-like growth factor receptor tyrosine kinases trafficking turnover Ubiquilin IGF1R (insulin-like growth factor-1 receptor) is a receptor tyrosine kinase ubiquitously expressed on cell surfaces of all tissues. Ligand...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (21): 3615–3626.
Published: 23 October 2017
... as that of the yeast HOPS complex. However, there is evidence of evolutionary divergence within the membrane trafficking system. Metazoan VPS33A and VPS33B are both homologues of the yeast HOPS subunit Vps33 [ 17 ], but only VPS33A is found in human HOPS [ 6 , 11 , 18 ] and mutations in these two homologues generate...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (3): 233–244.
Published: 25 January 2016
... that a specific N-glycan and the C-terminal disulfide loop of the helper subunit are key elements for biogenesis of system b 0,+ . cystinuria endoplasmic reticulum folding N-linked glycosylation trafficking transporter System b 0,+ mediates re-absorption of cystine and dibasic amino acids...
Includes: Supplementary data
Articles
Biochem J (2015) 472 (3): e27–e30.
Published: 27 November 2015
.... [(2015) Biochem. J. 470 , 319330] now demonstrates that ATP not only permeates pannexin 1 channels but stimulates the removal of pannexin 1 from the cell surface, providing negative feedback that limits pannexin 1 function. ATP endocytosis P2X7 pannexin 1 purine receptors trafficking...
Articles
Biochem J (2015) 470 (3): 319–330.
Published: 04 September 2015
... with regards to Panx1 surface stability in diverse scenarios in which ATP can be rapidly elevated in the extracellular space. adenosine 5′-triphosphate (ATP) endocytosis endosomes pannexin 1 pannexin1 trafficking Six individual pannexin 1 (Panx1) proteins come together to form channels...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2015) 468 (1): 177–190.
Published: 05 May 2015
... clearance of 5-HT from the synaptic cleft into presynaptic neurons. SERTs are primary targets for antidepressants for therapeutic intervention of mood disorders. Our previous studies have identified the involvement of several signalling pathways and protein kinases in regulating SERT function, trafficking...
Articles
Biochem J (2015) 467 (1): 127–139.
Published: 20 March 2015
...) transporter ATP-binding cassette subfamily B (ABCB) 6 lysosome trafficking transmembrane domain ATP-binding cassette (ABC) transporters are large membrane-spanning multidomain proteins promoting the ATP-dependent transmembrane transport of a vast array of biological compounds, including drugs...
Articles
Biochem J (2015) 465 (3): 471–477.
Published: 22 January 2015
... promotes surface expression of AMPA receptors; however, how TARP γ-8 regulates the expression of AMPA receptors remains unclear. In the present study, we examined the effect of TARP glycosylation on AMPA receptor trafficking. We first showed that TARP γ-8 is an N-glycosylated protein, which contains two...
Articles
Biochem J (2014) 464 (1): 145–156.
Published: 23 October 2014
..., although the downstream substrates mediating this function are not yet clear. In the present paper, we report the lipid kinase phosphatidylinositol 4-kinase II α (PI4KIIα) is a novel substrate of GSK3 that regulates trafficking and cell-surface expression of neurotransmitter receptors in neurons. GSK3...
Articles
Biochem J (2014) 463 (3): 339–349.
Published: 10 October 2014
... with dynamitin, a member of the microtubule-associated dynactin complex whose disruption affects the channel cell-surface density. dynactin Na v 1.5 protein complex sodium channel trafficking The voltage-gated sodium channel Na v 1.5 is responsible for action potential generation...
Articles
Biochem J (2014) 462 (1): 133–142.
Published: 24 July 2014
.... LQT1 compound mutations have been shown to increase channel dysfunction, but whether other disease mechanisms, such as defective channel trafficking, contribute to the increase in arrhythmic risk has not been determined. Using an imaging-based assay we investigated the effects of four compound...
Articles
Biochem J (2014) 458 (3): 513–523.
Published: 28 February 2014
... plastid and cytosol. We demonstrate that this enzyme has evolved to recognize and charge nuclear and organellar tRNA substrates. alternative splicing aminoacylation aminoacyl-tRNA synthetase apicoplast Apicomplexa dual-targeted Plasmodium Toxoplasma gondii trafficking tRNA aaRSs...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2013) 454 (2): 259–265.
Published: 09 August 2013
... stability side chain spinocerebellar ataxia type 13 (SCA13) trafficking Voltage-gated potassium (K v ) channels are a large family of ion channels that play a major role in setting the resting membrane potential and the threshold and firing pattern of action potentials [ 1 ]. The K v 3 subfamily...
Articles
Biochem J (2013) 453 (1): 147–151.
Published: 13 June 2013
...–adenine dinucleotide phosphate (NAADP) two-pore segment channel 1 (TPCN1) trafficking NAADP (nicotinic acid–adenine dinucleotide phosphate) is a potent and widespread Ca 2+ -mobilizing messenger [ 1 ]. It regulates processes as diverse as fertilization and differentiation [ 2 – 4 ]. Intriguingly...
Articles
Biochem J (2012) 445 (1): 101–111.
Published: 15 June 2012
... monomers. Although this cysteine seems not to be involved in regulation of trafficking to the plasma membrane, activity, substrate selectivity or oxidative gating of ZmPIP1s (Zm is Zea mays ), ZmPIP2s and hetero-oligomers, it increases oligomer stability under denaturating conditions. In addition, when...
Includes: Supplementary data
Articles
Biochem J (2012) 442 (2): 335–343.
Published: 13 February 2012
... from HemW in vitro . On the basis of these findings, we propose a role of HemW in haem trafficking. HemW-like proteins form a distinct phylogenetic clade that has not previously been recognized. 1 To whom correspondence should be addressed (email marc@solioz-scientific.ch ). 7 9 2011...
Includes: Supplementary data
Articles
Biochem J (2011) 435 (2): 509–518.
Published: 29 March 2011
... should be addressed (email histo6@post.tau.ac.il ). 16 11 2010 20 1 2011 3 2 2011 3 2 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 endoplasmic reticulum post-translational modification signalling trafficking ubiquitin vesicular stomatitis...
Articles
Biochem J (2011) 435 (1): 267–276.
Published: 15 March 2011
...-to-Golgi protein trafficking was also reduced by palmitate pre-treatment, but was overcome by overexpression of GlcCer synthase. This was accompanied by increased conversion of ceramide into GlcCer, and reduced ER stress and apoptosis, but no change in phospholipid desaturation. Sphingolipid alterations...
Includes: Supplementary data
Articles
Biochem J (2010) 426 (3): 379–388.
Published: 24 February 2010
... heterodimers. Therefore the patient carries one kAE1 mutant that is retained in the Golgi (G701D) and another kAE1 mutant (C479W) located in the endoplasmic reticulum of kidney cells, and is thus probably unable to reabsorb bicarbonate into the blood. We conclude that the C479W mutant is a novel trafficking...
Articles
Biochem J (2010) 425 (1): 195–208.
Published: 14 December 2009
... The Authors Journal compilation © 2010 Biochemical Society 2010 endoplasmic reticulum oxidoreductase protein disulfide isomerase (PDI) thioredoxin thioredoxin-like transmembrane protein 4 (TMX4) trafficking The relatively oxidizing conditions inside the lumen of the ER (endoplasmic...
Includes: Supplementary data
Articles
Biochem J (2009) 418 (1): 163–172.
Published: 28 January 2009
... mutant failed to co-localize with Rab11 and recycle to the plasma membrane, in contrast with the wild-type receptor. To our knowledge, the present study is the first report of a direct interaction between the β2AR and a Rab GTPase, which is required for the accurate intracellular trafficking...
Articles
Biochem J (2008) 414 (3): 431–440.
Published: 27 August 2008
... 2007 12 5 2008 14 5 2008 14 5 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 dileucine signal lysosome membrane p40 trafficking The vesicular transport of newly synthesized lysosomal membrane proteins from the TGN ( trans -Golgi network...
Articles
Biochem J (2008) 412 (3): 469–475.
Published: 28 May 2008
..., Germany (email sgruender@ukaachen.de ). 28 11 2007 13 2 2008 29 2 2008 29 2 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 acid-sensing ion channel (ASIC) N-glycans structure trafficking ASICs (acid-sensing ion channels) are H + -gated...
Articles
Biochem J (2008) 412 (3): 495–506.
Published: 28 May 2008
... is located in membrane rafts and reaches the cell surface through intracellular trafficking. In the present study we prove that GLYT2 constitutively recycles between the cell interior and the plasma membrane by means of a monensin-sensitive trafficking pathway. Also, a regulated trafficking can be triggered...
Articles
Biochem J (2008) 410 (3): 463–472.
Published: 27 February 2008
... manner in living cells and propose that ACBP may be involved in vesicular trafficking. 1 To whom correspondence should be addressed (email jkk@bmb.sdu.dk ). 25 4 2007 4 10 2007 22 10 2007 22 10 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008...
Includes: Supplementary data
Articles
Biochem J (2008) 410 (3): 585–594.
Published: 27 February 2008
...Kathryn A. Stern; Trenton L. Place; Nancy L. Lill EGF-R [EGF (epidermal growth factor) receptor] ligands can promote or inhibit cell growth. The biological outcome of receptor activation is dictated, at least in part, by ligand-specified patterns of endocytic trafficking. EGF-R trafficking...
Articles
Biochem J (2008) 409 (2): 555–562.
Published: 21 December 2007
... GPI-anchored proteins are targeted from the ER to the PM. In the present study, we investigated mechanisms underlying membrane trafficking of the GPI-anchored proteins, focusing on the early secretory pathway. We first established a cell line that stably expresses inducible temperature-sensitive GPI...
Articles
Biochem J (2007) 408 (3): 375–385.
Published: 28 November 2007
... of connexin trafficking and channel gating. It is well-documented that SDS/PAGE of NRK (normal rat kidney) cell lysates reveals at least three connexin43-specific bands (P0, P1 and P2). P1 and P2 are phosphorylated on multiple, unidentified serine residues and are found primarily in gap-junction plaques...
Articles
Biochem J (2007) 407 (2): 171–177.
Published: 25 September 2007
... MT1-MMP (membrane-type 1 matrix metalloproteinase) α1-PI (α1-proteinase inhibitor) trafficking MMPs (matrix metalloproteinases) are a family of zinc-dependent metalloendopeptidases that process a variety of substrates, including proMMP zymogens, extracellular matrix proteins, growth factors...
Articles
Biochem J (2007) 406 (1): 157–165.
Published: 26 July 2007
... (DAG) Golgi GTP-binding protein βγ subunits (Gβγ) phospholipase C (PLC) protein kinase D (PKD) trafficking Since the discovery of IQ (ilimaquinone)'s role in Golgi fragmentation [ 1 ], a wide variety of new vesicle trafficking regulatory proteins have been found and their cellular...
Articles
Biochem J (2007) 404 (3): 525–534.
Published: 29 May 2007
... the sorting of VAMP2 to vesicles before surface delivery, without influencing VAMP2 endocytosis. Consistent with this, dynamin and α-SNAP (soluble N -ethylmaleimide-sensitive fusion protein-attachment protein) mutants which block trafficking at the plasma membrane do not abrogate the effect of synaptophysin I...
Includes: Supplementary data
Articles
Biochem J (2006) 395 (2): 337–344.
Published: 28 March 2006
... protein may play additional roles other than nucleoside salvage, since it has recently been shown to be under purinergic control via K ATP channels, by a mechanism that does not seem to involve changes in its subcellular localization. In an attempt to identify the agents that promote CNT2 trafficking...
Articles
Biochem J (2005) 392 (3): 475–483.
Published: 06 December 2005
... localization trafficking In eukaryotic cells, mRNA localization to different regions in the cytoplasm provides a mechanism for synthesis of proteins close to where they are required [ 1 – 3 ]. For example, in fibroblasts some mRNAs, such as those encoding β-actin and creatine kinase isoform M...
Includes: Supplementary data
Articles
Biochem J (2005) 388 (1): 355–362.
Published: 10 May 2005
..., Watanabe, Gomez and Thornhill (2003) J. Biol. Chem. 278 , 25558–25567; Zhu, Watanabe, Gomez and Thornhill (2003) Biochem. J. 375 , 761–768]. In the present study, we focused on the deep pore region of Kv1 members to test whether a cell-surface trafficking code was dictated by two amino acids. Kv1 channels...
Articles
Biochem J (2005) 385 (1): 233–241.
Published: 14 December 2004
...Lorena PERRONE; Simona PALADINO; Marialuisa MAZZONE; Lucio NITSCH; Massimo GULISANO; Chiara ZURZOLO The topology and trafficking of receptors play a key role in their signalling capability. Indeed, receptor function is related to the microenvironment inside the cell, where specific signalling...
Articles
Biochem J (2004) 380 (3): 805–813.
Published: 15 June 2004
... in close proximity to the canalicular membrane to facilitate biliary copper excretion. In the present study, we investigated the role of the six N-terminal MBSs (metal-binding sites) in the trafficking process. Using site-directed mutagenesis, we mutated or deleted various combinations of the MBSs...
Articles
Biochem J (2004) 378 (3): 1031–1037.
Published: 15 March 2004
... in the Golgi compartment and effluxes excess copper from the cell. These roles can be achieved through copper-regulated trafficking of MNK. It has previously been shown to undergo trafficking from the trans -Golgi network to the plasma membrane in response to elevated copper concentrations...
Articles
Biochem J (2003) 375 (3): 761–768.
Published: 01 November 2003
...Jing ZHU; Itaru WATANABE; Barbara GOMEZ; William B. THORNHILL Kv1.4 and Kv1.1 potassium channel homomers have been shown to exhibit different intracellular trafficking programmes and cell-surface expression levels in cell lines: a determinant in the pore region of Kv1.4 and Kv1.1 [Zhu, Watanabe...
Articles
Biochem J (2003) 375 (2): 433–440.
Published: 15 October 2003
...-sensitive fusion protein attachment protein receptor (SNARE), synapto- some-associated protein-23 (SNAP23), syntaxin, trafficking, vesicle. INTRODUCTION The trafficking of proteins and lipids between organelles is mediated by transport vesicles that bud from a donor mem- brane and subsequently fuse...
Articles
Biochem J (2000) 350 (2): 337–352.
Published: 23 August 2000
... reference to the genetic and biochemical insights provided by study of the yeast Saccharomyces cerevisiae . 1 To whom correspondence should be addressed. The Biochemical Society, London © 2000 2000 actin endocytosis exocytosis phosphoinositide trafficking Biochem. J. (2000) 350, 337...
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Biochem J (2000) 350 (1): 149–154.
Published: 09 August 2000
... rate. The pattern of dynamic trafficking was seen only for GLUT2, not GLUT5 or SGLT1, implying that GLUT2 trafficks to the brush-border membrane by a different pathway. Trafficking of GLUT2 to the brush-border membrane correlated with activation of PKC βII, implying that this isoenzyme is likely...
Articles
Biochem J (2000) 350 (1): 99–107.
Published: 09 August 2000
...) and the proprotein convertase PC6B, indicating that this type of motif may play an important role in the endosomal sequestration of a number of different proteins. Key words: adipocyte, endosome, insulin, trafficking, trans- location. distribution within the endosomal lysosomal system. In many cases these signals...
Articles
Biochem J (2000) 349 (1): 51–57.
Published: 26 June 2000
...-mannose to a complex oligosaccharide with a half-time of approx. 4 h, which reflected the time course of trafficking of AE1 from the endoplasmic reticulum to the plasma membrane. The turnover of the complex form of the N555 mutant occurred with a half-life of approx. 15 h. The results show...