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Keywords: tight junction
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Articles

Calcium-mediated oxidative stress: a common mechanism in tight junction disruption by different types of cellular stress

Ruchika Gangwar, Avtar S. Meena, Pradeep K. Shukla, Archana S. Nagaraja, Piotr L. Dorniak, Sandeep Pallikuth, Christopher M. Waters, Anil Sood, RadhaKrishna Rao
Journal: Biochemical Journal
Biochem J (2017) 474 (5): 731–749.
DOI: https://doi.org/10.1042/BCJ20160679
Published: 20 February 2017
...Ruchika Gangwar; Avtar S. Meena; Pradeep K. Shukla; Archana S. Nagaraja; Piotr L. Dorniak; Sandeep Pallikuth; Christopher M. Waters; Anil Sood; RadhaKrishna Rao The role of reactive oxygen species (ROS) in osmotic stress, dextran sulfate sodium (DSS) and cyclic stretch-induced tight junction (TJ...
View article titled, Calcium-mediated oxidative stress: a common mechanism in <span class="search-highlight">tight</span> <span class="search-highlight">junction</span> disruption by different types of cellular stress
Click here to open pdf in another window PDF for Calcium-mediated oxidative stress: a common mechanism in <span class="search-highlight">tight</span> <span class="search-highlight">junction</span> disruption by different types of cellular stress
Includes: Supplementary data
Articles

Calcium/Ask1/MKK7/JNK2/c-Src signalling cascade mediates disruption of intestinal epithelial tight junctions by dextran sulfate sodium

Geetha Samak, Kamaljit K. Chaudhry, Ruchika Gangwar, Damodaran Narayanan, Jonathan H. Jaggar, RadhaKrishna Rao
Journal: Biochemical Journal
Biochem J (2015) 465 (3): 503–515.
DOI: https://doi.org/10.1042/BJ20140450
Published: 22 January 2015
...Geetha Samak; Kamaljit K. Chaudhry; Ruchika Gangwar; Damodaran Narayanan; Jonathan H. Jaggar; RadhaKrishna Rao Disruption of intestinal epithelial tight junctions is an important event in the pathogenesis of ulcerative colitis. Dextran sodium sulfate (DSS) induces colitis in mice with symptoms...
View article titled, Calcium&#x2F;Ask1&#x2F;MKK7&#x2F;JNK2&#x2F;c-Src signalling cascade mediates disruption of intestinal epithelial <span class="search-highlight">tight</span> <span class="search-highlight">junctions</span> by dextran sulfate sodium
Click here to open pdf in another window PDF for Calcium/Ask1/MKK7/JNK2/c-Src signalling cascade mediates disruption of intestinal epithelial <span class="search-highlight">tight</span> <span class="search-highlight">junctions</span> by dextran sulfate sodium
Includes: Supplementary data
Articles

Molecular and structural transmembrane determinants critical for embedding claudin-5 into tight junctions reveal a distinct four-helix bundle arrangement

Jan Rossa, Jonas Protze, Christian Kern, Anna Piontek, Dorothee Günzel, Gerd Krause, Jörg Piontek
Journal: Biochemical Journal
Biochem J (2014) 464 (1): 49–60.
DOI: https://doi.org/10.1042/BJ20140431
Published: 23 October 2014
...Jan Rossa; Jonas Protze; Christian Kern; Anna Piontek; Dorothee Günzel; Gerd Krause; Jörg Piontek The mechanism of TJ (tight junction) assembly and the structure of TJ strand-forming Cldns (claudins) are unclear. To identify determinants of assembly of blood–brain barrier-related Cldn3 and Cldn5...
View article titled, Molecular and structural transmembrane determinants critical for embedding claudin-5 into <span class="search-highlight">tight</span> <span class="search-highlight">junctions</span> reveal a distinct four-helix bundle arrangement
Click here to open pdf in another window PDF for Molecular and structural transmembrane determinants critical for embedding claudin-5 into <span class="search-highlight">tight</span> <span class="search-highlight">junctions</span> reveal a distinct four-helix bundle arrangement
Includes: Supplementary data
Articles

Sorting nexin 27 (SNX27) associates with zonula occludens-2 (ZO-2) and modulates the epithelial tight junction

Seth P. Zimmerman, Christina L. Hueschen, Daniela Malide, Sharon L. Milgram, Martin P. Playford
Journal: Biochemical Journal
Biochem J (2013) 455 (1): 95–106.
DOI: https://doi.org/10.1042/BJ20121755
Published: 13 September 2013
... of the endosomal system. SNX27 is the only sorting nexin that contains a PDZ domain. In the present study, we used a proteomic approach to identify a novel interaction between SNX27 and ZO-2 [zonula occludens-2; also known as TJP2 (tight junction protein 2)], a component of the epithelial tight junction. The SNX27...
View article titled, Sorting nexin 27 (SNX27) associates with zonula occludens-2 (ZO-2) and modulates the epithelial <span class="search-highlight">tight</span> <span class="search-highlight">junction</span>
Click here to open pdf in another window PDF for Sorting nexin 27 (SNX27) associates with zonula occludens-2 (ZO-2) and modulates the epithelial <span class="search-highlight">tight</span> <span class="search-highlight">junction</span>
Includes: Supplementary data
Articles

Post-transcriptional regulation of CLMP mRNA is controlled by tristetraprolin in response to TNFα via c-Jun N-terminal kinase signalling

Kit-Ling Sze, Wing-Yee Lui, Will M. Lee
Journal: Biochemical Journal
Biochem J (2008) 410 (3): 575–583.
DOI: https://doi.org/10.1042/BJ20070901
Published: 27 February 2008
... mechanisms involved in this event remain elusive. Recent studies have shown that pro-inflammatory cytokine TNFα (tumour necrosis factor α) plays a crucial role in this event by inhibiting the expression of tight junction proteins in Sertoli cells. In the present study, we sought to examine the detailed...
View article titled, Post-transcriptional regulation of CLMP mRNA is controlled by tristetraprolin in response to TNFα via c-Jun N-terminal kinase signalling
Click here to open pdf in another window PDF for Post-transcriptional regulation of CLMP mRNA is controlled by tristetraprolin in response to TNFα via c-Jun N-terminal kinase signalling
Articles

The transcription factors Slug and Snail act as repressors of Claudin-1 expression in epithelial cells

Ofelia M. Martínez-Estrada, Albert Cullerés, Francesc X. Soriano, Hector Peinado, Victoria Bolós, Fernando O. Martínez, Manuel Reina, Amparo Cano, Myriam Fabre, Senén Vilaró
Journal: Biochemical Journal
Biochem J (2006) 394 (2): 449–457.
DOI: https://doi.org/10.1042/BJ20050591
Published: 10 February 2006
...Ofelia M. Martínez-Estrada; Albert Cullerés; Francesc X. Soriano; Hector Peinado; Victoria Bolós; Fernando O. Martínez; Manuel Reina; Amparo Cano; Myriam Fabre; Senén Vilaró Claudin-1 is an integral membrane protein component of tight junctions. The Snail family of transcription factors...
View article titled, The transcription factors Slug and Snail act as repressors of Claudin-1 expression in epithelial cells
Click here to open pdf in another window PDF for The transcription factors Slug and Snail act as repressors of Claudin-1 expression in epithelial cells
Includes: Supplementary data
Articles

Depletion of Caco-2 cell cholesterol disrupts barrier function by altering the detergent solubility and distribution of specific tight-junction proteins

Daniel LAMBERT, Catherine A. O'NEILL, Philip J. PADFIELD
Journal: Biochemical Journal
Biochem J (2005) 387 (2): 553–560.
DOI: https://doi.org/10.1042/BJ20041377
Published: 05 April 2005
... proteins from the plasma membrane (tight junctions). In contrast, removal of cholesterol had no detectable influence on the detergent solubility or morphological distribution of claudin 1. These results indicate that membrane cholesterol is a critical factor in maintaining the barrier property...
View article titled, Depletion of Caco-2 cell cholesterol disrupts barrier function by altering the detergent solubility and distribution of specific <span class="search-highlight">tight</span>-<span class="search-highlight">junction</span> proteins
Click here to open pdf in another window PDF for Depletion of Caco-2 cell cholesterol disrupts barrier function by altering the detergent solubility and distribution of specific <span class="search-highlight">tight</span>-<span class="search-highlight">junction</span> proteins
Articles

Tyrosine phosphorylation and dissociation of occludin–ZO-1 and E-cadherin–β-catenin complexes from the cytoskeleton by oxidative stress

Radhakrishna K. RAO, Shyamali BASUROY, Vijay U. RAO, Karl J. KARNAKY, Jr, Akshay GUPTA
Journal: Biochemical Journal
Biochem J (2002) 368 (2): 471–481.
DOI: https://doi.org/10.1042/bj20011804
Published: 01 December 2002
... with INTRODUCTION The tight junctions (TJs) and the adherens junctions (AJs) form the barrier to the diffusion of macromolecules across the epi- thelium in different tissues. Whereas TJs form a physical barrier to the diffusion of macromolecules through the paracellular space, AJs may indirectly regulate...
View article titled, Tyrosine phosphorylation and dissociation of occludin–ZO-1 and E-cadherin–β-catenin complexes from the cytoskeleton by oxidative stress
Click here to open pdf in another window PDF for Tyrosine phosphorylation and dissociation of occludin–ZO-1 and E-cadherin–β-catenin complexes from the cytoskeleton by oxidative stress