... researchers to generate an impressive amount of data on the role of class I PI3Kα, β, δ and γ in platelet activation and in thrombosis. Furthermore, platelets do also express two class II PI3Ks (PI3KC2α and PI3KC2β), thought to generate PtdIns(3,4)P 2 and PtdIns3P, and the sole class III PI3K (Vps34), known...

... thrombosis The activities of Rho GTPase proteins are central to many of the processes that underpin the physiological and pathological roles of platelets [ 1 ]. Platelets are small, disc-shaped cells with a short lifespan that number in the hundreds of millions per millilitre of blood...

... (AD) calcium platelet secretion thrombosis Abnormal metabolism of the APP (amyloid precursor protein) through the amyloidogenic pathway results in the accumulation of heterogeneous Aβ (amyloid β)-peptides (40–42 amino acids) in the central nervous system, causing the onset of AD...

...@unsw.edu.au ). 20 4 2011 18 5 2011 20 5 2011 20 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 coagulation disulfide bond haemostasis redox potential thrombosis tissue factor TF (tissue factor) is the primary initiator of blood...

... and cytometry showed that platelets not only contain Gal-8, but also expose Gal-8 after thrombin activation. These findings reveal Gal-8 as a potent platelet activator, supporting a role for this lectin in thrombosis and inflammation. 1 These authors contributed equally to this work. 2...

... simplex virus Herpesvirus thrombosis To confirm and quantify the relative amount of gC and TF on purified HSV1 strains, virus proteins were subjected to SDS/12% PAGE followed by electrotransfer on to PVDF membranes and evaluated by Western blot analysis [ 23 ]. Antigen was detected by incubation...

... 27 3 2003 30 4 2003 30 4 2003 The Biochemical Society, London ©2003 2003 cancer protease serpin therapeutic target thrombosis Abbreviations used: bis-ANS, 4,4′-dianilino-1,1′-bisnaphthyl-5,5′-disulphonic acid, dipotassium salt; h, α-helix; HBS, Hepes-buffered...

... to pathological protein polymerization in general. 1 To whom correspondence should be addressed (e-mail kep@mb.au.dk ). 2 12 2002 24 3 2003 26 3 2003 26 3 2003 The Biochemical Society, London ©2003 2003 cancer polymerization serpin thrombosis urokinase...

... metalloproteinases thrombosis Abbreviations used: berythractivase, B. erythr omelas prothrombin activase ; CONICET, Consejo Nacional de Investigaciones Científicas y Técnicas; E-64, trans -epoxysuccinyl- l -leucylamido-(4-guanidino)butane; FBS, fetal bovine serum; HUVECs, human umbilical-vein...

... proteinase gelatinase-A proteinase inhibitors angiogenesis thrombosis Abbreviations used: BCA, bicinchronic acid; con A, concanavalin A; E64, trans -epoxysuccinyl- l -leucylamido-(4-guanidino)butane; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; HUVEC, human umbilical-vein endothelial cell...