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Keywords: thrombosis
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Biochem J (2020) 477 (22): 4327–4342.
Published: 26 November 2020
... researchers to generate an impressive amount of data on the role of class I PI3Kα, β, δ and γ in platelet activation and in thrombosis. Furthermore, platelets do also express two class II PI3Ks (PI3KC2α and PI3KC2β), thought to generate PtdIns(3,4)P 2 and PtdIns3P, and the sole class III PI3K (Vps34), known...
Biochem J (2015) 466 (3): 431–442.
Published: 06 March 2015
... protein 42 (Cdc42) Rif RhoG shape change secretion thrombosis The activities of Rho GTPase proteins are central to many of the processes that underpin the physiological and pathological roles of platelets [ 1 ]. Platelets are small, disc-shaped cells with a short lifespan that number...
Biochem J (2014) 462 (3): 513–523.
Published: 22 August 2014
... platelet secretion thrombosis Abnormal metabolism of the APP (amyloid precursor protein) through the amyloidogenic pathway results in the accumulation of heterogeneous Aβ (amyloid β)-peptides (40–42 amino acids) in the central nervous system, causing the onset of AD (Alzheimer's disease) [ 1 , 2...
Includes: Supplementary data
Biochem J (2011) 437 (3): 455–460.
Published: 13 July 2011
...@unsw.edu.au ). 20 4 2011 18 5 2011 20 5 2011 20 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 coagulation disulfide bond haemostasis redox potential thrombosis tissue factor TF (tissue factor) is the primary initiator of blood...
Biochem J (2010) 432 (3): 535–547.
Published: 25 November 2010
... and cytometry showed that platelets not only contain Gal-8, but also expose Gal-8 after thrombin activation. These findings reveal Gal-8 as a potent platelet activator, supporting a role for this lectin in thrombosis and inflammation. 1 These authors contributed equally to this work. 2...
Biochem J (2003) 373 (3): 723–732.
Published: 01 August 2003
... as a therapeutic target. Key words: cancer, protease, serpin, therapeutic target, thrombosis. INTRODUCTION The tissue- and urokinase-type plasminogen activators (tPA and uPA respectively) are serine proteases catalysing proteolytic con- version of the zymogen plasminogen into the active serine protease plasmin...