... demand for sugars, amino acids, and lipids and therefore up-regulate various nutrient transporters to meet this demand. In PDAC, SLC6A14 (an amino acid transporter (AAT)) is up-regulated, affecting overall patient survival. Previously we have shown using in vitro cell culture models and in vivo xenograft...

... activity to ensure in vivo survival and a full virulence effect in a mammalian host. 1 To whom correspondence should be addressed (email matthew.francis@molbiol.umu.se ). 3 5 2011 28 6 2011 4 7 2011 4 7 2011 © The Authors Journal compilation © 2011 Biochemical Society...

...) are essential for survival inside of host macrophages. These genes act as an operon and have been suggested to be involved in cholesterol metabolism. However, the role of NAT in this catabolic pathway has not been determined. In an effort to better understand the function of these proteins, we have expressed...

...Jahangir KABIR; Melvin LOBO; Ian ZACHARY The survival of endothelial cells is dependent on interactions between the matrix and integrins mediated through focal adhesions. Focal adhesion kinase (FAK) is thought to play a key role in maintaining focal adhesion function and cell survival, whereas...

... and several cytokines [4 6] and elicits an array of biological activities in ŠiŠo and in Šitro, including the survival, proliferation and migration of endothelial cells [7 9], the endothelial production of NO and prostaglandin I # (PGI # ) [10 13] and increased vascular perme- ability [14]. Two protein...