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Keywords: steroidogenesis
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Biochem J (2022) 479 (13): 1455–1466.
Published: 12 July 2022
..., energy metabolism and steroidogenesis. We also report how it is involved in neuroinflammation, brain injury and diseases of the nervous system. The release of four manuscripts in 2014 and 2015 did not show the involvement of TSPO in serum steroidogenesis. In fact, these research groups showed normal...
Biochem J (2018) 475 (5): 901–904.
Published: 06 March 2018
...Barbara Costa; Eleonora Da Pozzo; Claudia Martini Two interesting papers by Barren et al. and Owen et al. have been very recently published in Biochemical Journal , reporting the role of translocator protein (TSPO) in steroidogenesis. The involvement of TSPO in the steroid biosynthesis has been...
Biochem J (2018) 475 (1): 75–85.
Published: 02 January 2018
... in steroidogenesis has recently been challenged by the development of TSPO knockout (TSPO-KO) mice, as they exhibit normal baseline gonadal testosterone and adrenal corticosteroid production. Here, we demonstrate that despite normal androgen levels in young male TSPO-KO mice, TSPO deficiency alters steroidogenic...
Biochem J (2010) 432 (3): 473–486.
Published: 25 November 2010
... and Y-1 cells respectively. Finally, we demonstrated that PGC-1α induces SF-1 gene expression in both αT3-1 and Y-1 cells. Taken together, our findings reveal the potential role of PGC-1α and suggest that it may play important roles in steroidogenesis, gonad development and sex differentiation through...
Includes: Supplementary data
Biochem J (2010) 431 (1): 159–167.
Published: 14 September 2010
... enzyme lend support to the notion that particular GSTs play an important role in steroidogenesis. 1 To whom correspondence should be addressed (email Bengt.Mannervik@biorg.uu.se ). 8 6 2010 29 7 2010 30 7 2010 30 7 2010 © The Authors Journal compilation © 2010...
Includes: Supplementary data
Biochem J (2009) 419 (1): 201–209.
Published: 13 March 2009
... and mutation of the SUMO acceptor sites increased the transcriptional activity of Sp3 [ 29 ]. LRH-1 has been shown to regulate steroidogenic gene expression, yet the molecular mechanisms of LRH-1 function in steroidogenesis are not clear. In the present study, we have demonstrated that the LRH-1-dependent...
Biochem J (2008) 412 (3): 553–562.
Published: 28 May 2008
...Alireza Roostaee; Élie Barbar; Jean-Guy LeHoux; Pierre Lavigne Steroidogenesis depends on the delivery of cholesterol from the outer to the inner mitochondrial membrane by StAR (steroidogenic acute regulatory protein). However, the mechanism by which StAR binds to cholesterol and its importance...
Includes: Supplementary data
Biochem J (2000) 350 (3): 785–790.
Published: 08 September 2000
... steroidogenesis transcription Biochem. J. (2000) 350, 785 790 (Printed in Great Britain) 785 Contribution of steroidogenic factor 1 to the regulation of cholesterol synthesis Cristina MASCARO! , Alicia NADAL, Fausto G. HEGARDT, Pedro F. MARRERO and Diego HARO1 Department of Biochemistry and Molecular Biology...