...Alexander C. Jones; Alexandr P. Kornev; Jui-Hung Weng; Gerard Manning; Susan S. Taylor; Alexandra C. Newton Conventional protein kinase C (cPKC) isozymes tune the signaling output of cells, with loss-of-function somatic mutations associated with cancer and gain-of-function germline mutations...

... cycle from fertilization to seed set. Thirty years of research on plant RKs has generated a wealth of knowledge on how RKs perceive ligands and activate downstream signaling. In the present review, we synthesize this body of knowledge into five central paradigms of plant RK signaling: (1) RKs...

... component of this compute function is the dynamic regulation of RAS activation and downstream signaling that allows RAS to produce a rich and nuanced spectrum of biological outputs. We discuss recent findings how the dynamics of RAS and its downstream signaling is regulated. Starting from the structural...

... of the signaling, transport and structural roles the lipid plays at the cell surface in animal cells. These include being substrate for second messenger generation, direct modulation of receptors, control of membrane traffic, regulation of ion channels and transporters, and modulation of the cytoskeleton and cell...

... the KRAS G12C mutation commonly found in lung cancer. We investigated emergent resistance to representative examples of different classes of Ras targeted therapies. They all exhibited rapid reactivation of Ras signaling within days of exposure and adaptive responses continued to change over long-term...

... Press and the Biochemical Society under a transformative agreement with JISC. G-proteins leucine-rich repeat kinase Parkinson's disease signaling One-to four percent of all cases of Parkinson's disease (PD) are caused by genetic changes in leucine-rich repeat kinase-2 (LRRK2) [ 1–3...

... transforming growth factor β (TGF-β), a master regulator of the fibrotic signaling cascade. Based on mRNA and protein expression profiling data, we found that αVβ1 integrin is the most abundant member of the αV integrin family in either quiescent or TGF-β1-activated primary human HSCs. Unexpectedly, either...

... intracellular transport signaling sterols Cell wall maintenance is mostly regulated by the Cell Wall Integrity (CWI) signaling pathway in fungi [ 12 ]. Very briefly, this pathway consists of PM localized sensors, such as Wsc1p and Mid2p, that relay to the small GTPase Rho1p. This protein activates...

...Monica Gonzalez-Magaldi; Jacqueline M. McCabe; Haley N. Cartwright; Ningze Sun; Daniel J. Leahy Receptor Tyrosine Kinases (RTKs) comprise a diverse group of cell-surface receptors that mediate key signaling events during animal development and are frequently activated in cancer. We show here...

...Manoj Kumar; Komal Sharma; Akhilesh K. Yadav; Kajal Kanchan; Madhu Baghel; Suneel Kateriya; Girdhar K. Pandey Calcium (Ca 2+ ) signaling is involved in the regulation of diverse biological functions through association with several proteins that enable them to respond to abiotic and biotic stresses...

...Kaustav Gangopadhyay; Bharat Manna; Swarnendu Roy; Sunitha Kumari; Olivia Debnath; Subhankar Chowdhury; Amit Ghosh; Rahul Das T-cell receptor (TCR) signaling is initiated by recruiting ZAP-70 to the cytosolic part of TCR. ZAP-70, a non-receptor tyrosine kinase, is composed of an N-terminal tandem...

...Takuya Kojima; Yosuke Funato; Hiroaki Miki Phosphatase of regenerating liver (PRL) is overexpressed in metastatic cancers and actively drives their malignant progression. Many studies on cultured cancer cells have implied PRL overexpression as a stimulant for cellular signaling involved in cell...

... Cu(I)/Ag(I) concentrations to help maintain metal ion homeostasis. The CusS histidine kinase is a homodimeric integral membrane protein that binds to periplasmic Cu(I)/Ag(I) and transduces a signal to its cytoplasmic kinase domain. However, the mechanism of how metal binding in the periplasm...

... signaling, but the mechanism of inactivation of the Axl receptor is poorly understood. In the present study, we show that IQGAP1 modulates Axl signaling. IQGAP1 is a scaffold protein that integrates cell signaling pathways by binding several growth factor receptors and intracellular signaling molecules. Our...

...Blanca E. Ruiz-Medina; Denisse A. Cadena-Medina; Edmundo Esparza; Amy J. Arrieta; Robert A. Kirken Regulation of intracellular signaling pathways in lymphocytes is critical for cell homeostasis and immune response. Interleukin-2 (IL-2), a key regulator of lymphocytes, signals following receptor...

...Mary Mirvis; Tim Stearns; W. James Nelson The cilium, once considered a vestigial structure, is a conserved, microtubule-based organelle critical for transducing extracellular chemical and mechanical signals that control cell polarity, differentiation, and proliferation. The cilium undergoes cycles...

...-proliferative, multinucleated syncytium. This syncytium covers the placenta and manages the exchange of nutrients and gases between maternal and fetal circulation. We recently reported protein kinase A (PKA) to be part of a macromolecular signaling complex with ezrin and gap junction protein connexin 43 (Cx43...

... on behalf of the Biochemical Society 2017 inhibition receptor tyrosine kinases signaling c-FMS, perhaps better known as colony-stimulating factor 1 receptor (CSF1R) or macrophage colony-stimulating factor receptor (M-CSFR), is a receptor tyrosine kinase (RTK) in the PDGFR subfamily...

...) that requires hundreds of sequences to identify functionally critical sectors, the propagation and dissipation of perturbations within proteins and the higher-order couplings deduced from detailed NMR experiments. Our results thus shed light on the possible mechanistic origins of signaling through...

...Akshay Bareja; Conrad P. Hodgkinson; Alan J. Payne; Richard E. Pratt; Victor J. Dzau We have recently shown that hypoxia and Akt-induced stem cell factor (HASF) protects the heart from ischemia-induced damage and promotes cardiomyocyte proliferation. While we have identified certain signaling...

... in a variety of cancers. EphA3 activation is believed to follow a ‘seeding mechanism’ model, in which ligand binding to the monomeric receptor acts as a trigger for signal-productive receptor clustering. We study EphA3 lateral interactions on the surface of live cells and we demonstrate that EphA3 forms dimers...