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Keywords: ribosome
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Biochem J (2024) 481 (3): 119–139.
Published: 29 January 2024
... with Portland Press and the Biochemical Society under a transformative agreement with MPDL. cotranslational import hitch-hiking import mitochondria mRNA localization mRNA transport ribosome translation Creating order from chaos is an energy-demanding task, no matter whether we talk about...
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Biochem J (2020) 477 (15): 2921–2934.
Published: 14 August 2020
...Rodrigo D. Requião; Géssica C. Barros; Tatiana Domitrovic; Fernando L. Palhano Protein segments with a high concentration of positively charged amino acid residues are often used in reporter constructs designed to activate ribosomal mRNA/protein decay pathways, such as those involving nonstop mRNA...
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Biochem J (2019) 476 (15): 2209–2219.
Published: 09 August 2019
...Catherine E. Scull; Yinfeng Zhang; Nichole Tower; Lynn Rasmussen; Indira Padmalayam; Robert Hunter; Ling Zhai; Robert Bostwick; David A. Schneider Over the past two decades, ribosome biogenesis has emerged as an attractive target for cancer treatment. In this study, two high-throughput screens were...
Includes: Supplementary data
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Biochem J (2015) 466 (3): 547–559.
Published: 06 March 2015
...), an essential process for overcoming starvation. In Saccharomyces cerevisiae , sensing amino acid shortages requires that Gcn2 binds directly to its effector protein Gcn1 and both must associate with the ribosome. Our hypothesis is that uncharged tRNAs occur in the ribosomal A-site and that Gcn1 is directly...
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Biochem J (2014) 460 (1): 59–69.
Published: 25 April 2014
... proteins) are organized into two distinct dimers, P1A–P2B and P1B–P2A. To investigate the functional contribution of each dimer on the ribosome, RTA (ricin A chain), which binds to the stalk to depurinate the SRL (sarcin/ricin loop), was used as a molecular probe in yeast mutants in which the binding site...
Includes: Supplementary data
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Biochem J (2008) 413 (3): 527–534.
Published: 15 July 2008
...Francisco Martinez-Azorin; Miguel Remacha; Juan P. G. Ballesta The ‘stalk’ is a large ribosomal subunit domain that regulates translation. In the present study the role of the ribosomal stalk P proteins in modulating ribosomal activity has been investigated in human cells using RNA interference...
Includes: Supplementary data
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Biochem J (2008) 412 (1): 73–80.
Published: 25 April 2008
... predominates in high-molecular-mass complexes. Loss of TSA1 results in aggregation of ribosomal proteins, indicating that Tsa1 functions to maintain the integrity of the translation apparatus. In the present study we report that Tsa1 functions as an antioxidant on actively translating ribosomes. Its peroxidase...
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Biochem J (2008) 409 (1): 223–231.
Published: 11 December 2007
... initiation and in its control, and in regulation of ribosomes. Here, we establish that the interaction of ABC50 with eIF2 involves features in the N-terminal domain of ABC50, the region of ABC50 that differs most markedly from other ABC proteins. This region also shows no apparent similarity to the eIF2...
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Biochem J (2007) 403 (2): 217–234.
Published: 26 March 2007
... and the mechanisms by which the translation of specific mRNAs is controlled. 3 1 2007 7 2 2007 8 2 2007 The Authors Journal compilation, The Biochemical Society, London 2007 mammalian target of rapamycin (mTOR) mRNA mRNA translation ribosome signal transduction translation factor...
Includes: Multimedia, Supplementary data
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Biochem J (2005) 389 (3): 843–852.
Published: 26 July 2005
.... In phenotypic studies, depletion of yloQ sensitized cells to antibiotics that bind at the peptide channel or peptidyl transferase centre, providing the first chemical genetic evidence linking this GTPase to ribosome function. Additional experiments using these small-molecule probes in vitro revealed...
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Biochem J (2005) 386 (1): 85–91.
Published: 08 February 2005
... this PRMT3-interacting protein as rpS2 (ribosomal protein S2). In vitro studies showed that the zinc-finger domain of PRMT3 is necessary and sufficient for binding to rpS2. In addition, rpS2 is methylated by PRMT3 in vitro and is also methylated in cell lines. Deletion analysis of the rpS2 amino acid...
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Biochem J (2004) 384 (2): 239–246.
Published: 23 November 2004
... components of Staufen 1-containing particles. Whereas the nucleocytoplasmic RNA-binding protein nucleolin is linked to Staufen in an RNA-dependent manner, the association of protein phosphatase 1, the microtubule-dependent motor protein kinesin and several components of the large and small ribosomal subunits...
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Biochem J (2003) 371 (3): 641–651.
Published: 01 May 2003
...Maciej SZYMAŃSKI; Mirosawa Z. BARCISZEWSKA; Volker A. ERDMANN; Jan BARCISZEWSKI 5S rRNA is an integral component of the large ribosomal subunit in all known organisms. Despite many years of intensive study, the function of 5S rRNA in the ribosome remains unknown. Advances in the analysis...
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Biochem J (2000) 348 (3): 597–606.
Published: 07 June 2000
... not only plays an essential role to ensure the N-terminus-outside/C-terminus-inside orientation of TM1 with an extracellular N-terminus, it can also translocate into membranes post-translationally in a signal-recognition particle and ribosome-dependent manner to provide an additional insurance for correct...