... Rowe; Matthew P. Hardy Human Complement Receptor 1 (HuCR1) is a potent membrane-bound regulator of complement both in vitro and in vivo , acting via interaction with its ligands C3b and C4b. Soluble versions of HuCR1 have been described such as TP10, the recombinant full-length extracellular domain...

...Courtney M. Smith; Alice Li; Nithya Krishnamurthy; Mark A. Lemmon Co-signaling receptors for the T cell receptor (TCR) are important therapeutic targets, with blockade of co-inhibitory receptors such as PD-1 now central in immuno-oncology. Advancing additional therapeutic immune modulation...

...Henning Mühlenbeck; Kyle W. Bender; Cyril Zipfel Reversible protein phosphorylation is a widespread post-translational modification fundamental for signaling across all domains of life. Tyrosine (Tyr) phosphorylation has recently emerged as being important for plant receptor kinase (RK)-mediated...

... signaling receptors from filopodia. Type I insulin-like growth factor receptor (IGF1R) is a key regulator of normal development and growth, as well as tumor development and progression. Its biological roles depend on its activation upon IGF1 binding at the cell membrane. IGF1R behavior at the cell membrane...

...Laëtitia Gorisse; Zhigang Li; Andrew C. Hedman; David B. Sacks Axl is a tyrosine kinase receptor that is important for hematopoiesis, the innate immune response, platelet aggregation, engulfment of apoptotic cells and cell survival. Binding of growth arrest-specific protein 6 (Gas6) activates Axl...

...Vincenzo Di MARZO; Dominique MELCK; Pierangelo ORLANDO; Tiziana BISOGNO; Orna ZAGOORY; Maurizio BIFULCO; Zvi VOGEL; Luciano de PETROCELLIS Palmitoylethanolamide (PEA) has been shown to act in synergy with anandamide (arachidonoylethanolamide; AEA), an endogenous agonist of cannabinoid receptor type...

...Stefan PFLANZ; Thomas KERNEBECK; Bernd GIESE; Andreas HERRMANN; Michael PACHTA-NICK; Jürgen STAHL; Axel WOLLMER; Peter C. HEINRICH; Gerhard MÜLLER-NEWEN; Joachim GRÖTZINGER Glycoprotein 130 (gp130) is a type I transmembrane protein and serves as the common signal-transducing receptor subunit...

...Tomas DRMOTA; Graeme MILLIGAN The C-terminal tail of the long splice variant of the rat thyrotropin-releasing hormone (TRH) receptor-1 (TRHR-1L) comprises around 93 amino acids. A series of C-terminal truncations was constructed and expressed transiently in HEK-293 cells. The extent of steady-state...

... inhibitor p21 to a greater extent than FGF2. Neither ligand influenced apoptosis. The results indicate that FGF9 could account for many of the physiological responses attributed to FGF-receptor activation in the growth plate. 1 To whom correspondence should be addressed (e-mail wah@shcc.org). 26...

... the inhibition of human platelet AC by collagen, thrombin and adrenaline. Here it has been demonstrated that neither affinities of receptors specific for adrenaline or thrombin nor the activity of cAMP phosphodiesterase are affected by collagen. Both collagen and thrombin at high doses act as effective...

... to an impaired clearance of very-low-density lipoprotein (VLDL) particles from the circulation. In the absence of at least the low-density-lipoprotein receptor (LDLR), it was shown that APOC1 overexpression in transgenic mice inhibited the hepatic uptake of VLDL via the LDLR-related protein. In the present study...