...Piyali Majumder; Kaushik Chanda; Debajyoti Das; Brijesh Kumar Singh; Partha Chakrabarti; Nihar Ranjan Jana; Debashis Mukhopadhyay Alzheimer's Disease (AD) and Type 2 Diabetes (T2D) share a common hallmark of insulin resistance. Reportedly, two non-canonical Receptor Tyrosine Kinases (RTKs), ALK...

... the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . phosphorylation/dephosphorylation receptor tyrosine kinases receptors All organisms must perceive external cues for adaptation of their physiology to changing environmental conditions. Either cell-surface or cytosolic receptors...

...Fozia Ahmed; Michael D. Paul; Kalina Hristova Tropomyosin receptor kinase B (Trk-B) belongs to the second largest family of membrane receptors, Receptor Tyrosine Kinases (RTKs). Trk-B is known to interact with three different neurotrophins: Brain-Derived Neurotrophic Factor (BDNF), Neurotrophin-4...

...Monica Gonzalez-Magaldi; Jacqueline M. McCabe; Haley N. Cartwright; Ningze Sun; Daniel J. Leahy Receptor Tyrosine Kinases (RTKs) comprise a diverse group of cell-surface receptors that mediate key signaling events during animal development and are frequently activated in cancer. We show here...

...Stephen C. Artim; Anatoly Kiyatkin; Mark A. Lemmon The tropomyosin-related kinase (Trk) family consists of three receptor tyrosine kinases (RTKs) called TrkA, TrkB, and TrkC. These RTKs are regulated by the neurotrophins, a class of secreted growth factors responsible for the development...

.... epithelial-to-mesenchymal transition receptor tyrosine kinases signaling MET is a receptor tyrosine kinase (RTK), which was originally discovered as a part of an oncogenic fusion protein in human osteosarcoma-derived cells [ 1 ]. Biochemical analyses revealed that MET is the functional receptor...

...Fozia Ahmed; Kalina Hristova Receptor tyrosine kinases (RTKs) are cell surface receptors which control cell growth and differentiation, and play important roles in tumorigenesis. Despite decades of RTK research, the mechanism of RTK activation in response to their ligands is still under debate...

... that they were not transfected. In addition, endogenous IQGAP1 was immunoprecipitated from MDA-MB-231 cells with anti-IQGAP1 polyclonal antibodies. Nonimmune rabbit serum was used as control for polyclonal immunoprecipitation. molecular scaffolds receptor tyrosine kinases receptors signaling...

...Zimple Kurlawala; Rain Dunaway; Parag P. Shah; Julie A. Gosney; Leah J. Siskind; Brian P. Ceresa; Levi J. Beverly Insulin-like growth factor-1 receptor (IGF1R) is a receptor tyrosine kinase that mediates growth, proliferation and survival. Dysregulation of IGF pathway contributes to the initiation...

...Daryl E. Klein Inhibiting receptor tyrosine kinases has been a cornerstone of cancer therapeutics for decades. Treatment strategies largely involve small-molecule kinase inhibitors and monoclonal antibodies. For receptors activated by constitutively dimeric ligands, another potential mechanism...

... into the sequence–structure–function relationships of the M-CSF/c-FMS interaction and of ligand/receptor tyrosine kinase interactions in general. Correspondence: Mickey Kosloff ( kosloff@sci.haifa.ac.il ), Noam Levaot ( levaot@bgu.ac.il ) or Niv Papo ( papo@bgu.ac.il ) * These authors contributed equally...