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Selenophosphate synthetase 1 is an essential protein with roles in regulation of redox homoeostasis in mammals

Ryuta Tobe, Bradley A. Carlson, Jang Hoe Huh, Nadia P. Castro, Xue-Ming Xu, Petra A. Tsuji, Sang-Goo Lee, Jeyoung Bang, Ji-Woon Na, Young-Yun Kong, Daniel Beaglehole, Eileen Southon, Harold Seifried, Lino Tessarollo, David S. Salomon, Ulrich Schweizer, Vadim N. Gladyshev, Dolph L. Hatfield, Byeong Jae Lee

Biochem J (2016) 473 (14): 2141–2154.

DOI: https://doi.org/10.1042/BCJ20160393

Published: 12 July 2016

... cells were reversed, suggesting that SPS1 played a role in supporting and/or sustaining cancer. In addition, the overexpression of mouse or human GLRX1 led to a reversal of observed increases in reactive oxygen species (ROS) in the F9 SPS1/GLRX1-deficient cells and resulted in levels that were similar...

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Loss of conserved Gsdma3 self-regulation causes autophagy and cell death

Peiliang Shi, An Tang, Li Xian, Siyuan Hou, Dayuan Zou, Yasu Lv, Zan Huang, Qinghua Wang, Anying Song, Zhaoyu Lin, Xiang Gao

Biochem J (2015) 468 (2): 325–336.

DOI: https://doi.org/10.1042/BJ20150204

Published: 22 May 2015

.... autophagy Gasdermin A3 GSDM family reactive oxygen species (ROS) The skin is one of the largest organs in the human body. The epidermis consists of stratified squamous epithelium and has an outermost cornified layer that forms a protective barrier against the external environment. The skin...

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C/EBP homologous protein (CHOP) contributes to hepatocyte death via the promotion of ERO1α signalling in acute liver failure

Jianhua Rao, Chuangyong Zhang, Ping Wang, Ling Lu, Xiaofeng Qian, Jianjie Qin, Xiongxiong Pan, Guoqiang Li, Xuehao Wang, Feng Zhang

Biochem J (2015) 466 (2): 369–378.

DOI: https://doi.org/10.1042/BJ20140412

Published: 20 February 2015

... oxidoreductin 1-α (ERO1α), a target of CHOP, is an important oxidizing enzyme that regulates reactive oxygen species (ROS), which play a prominent role in hepatocellular death during acute liver failure (ALF). However, little is known about how CHOP facilitates ROS-induced hepatocellular injury. The present...

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SIRT3 interactions with FOXO3 acetylation, phosphorylation and ubiquitinylation mediate endothelial cell responses to hypoxia

Anne H.-H. Tseng, Li-Hong Wu, Shyan-Shu Shieh, Danny Ling Wang

Biochem J (2014) 464 (1): 157–168.

DOI: https://doi.org/10.1042/BJ20140213

Published: 23 October 2014

... (SIRT3) reactive oxygen species (ROS) mitochondrial antioxidant enzyme The oxygen supply to cells or tissues is reduced during aging and in many pathological conditions, including cancer, diabetic retinopathy and cardiovascular diseases [ 1 ]. Low oxygen supply results in hypoxic stress...

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A small molecule that induces reactive oxygen species via cellular glutathione depletion

Tatsuro Kawamura, Yasumitsu Kondoh, Makoto Muroi, Makoto Kawatani, Hiroyuki Osada

Biochem J (2014) 463 (1): 53–63.

DOI: https://doi.org/10.1042/BJ20140669

Published: 08 September 2014

...Tatsuro Kawamura; Yasumitsu Kondoh; Makoto Muroi; Makoto Kawatani; Hiroyuki Osada Induction of excessive levels of reactive oxygen species (ROS) by small-molecule compounds has been considered a potentially effective therapeutic strategy against cancer cells, which are often subjected to chronic...

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Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

Hannah R. Bridges, Andrew J. Y. Jones, Michael N. Pollak, Judy Hirst

Biochem J (2014) 462 (3): 475–487.

DOI: https://doi.org/10.1042/BJ20140620

Published: 22 August 2014

... reactive oxygen species (ROS) Metformin is the most commonly prescribed drug for Type II diabetes. It decreases blood glucose by mechanisms thought to involve the activation of AMPK (AMP-activated protein kinase) [ 1 ] and/or inhibition of adenylate cyclase [ 2 ] in response to energetic stress...

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Recombinant form of mammalian gp91 phox is active in the absence of p22 phox

Aymen Ezzine, Hager Souabni, Tania Bizouarn, Laura Baciou

Biochem J (2014) 462 (2): 337–345.

DOI: https://doi.org/10.1042/BJ20131620

Published: 07 August 2014

... protein–protein interaction reactive oxygen species (ROS) The NADPH oxidase complex generates ROS (reactive oxygen species) by transferring electrons from NADPH across biological membranes to dioxygen. These reactions occur through the membrane catalytic subunit which presents conserved...

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Genetic ablation of plasmoDJ1, a multi-activity enzyme, attenuates parasite virulence and reduces oocyst production

Neha Singhal, Atul, Babu S. Mastan, Kota Arun Kumar, Puran Singh Sijwali

Biochem J (2014) 461 (2): 189–203.

DOI: https://doi.org/10.1042/BJ20140051

Published: 26 June 2014

... malaria peroxiredoxin Plasmodium reactive oxygen species (ROS) Malaria, a disease caused by protozoan parasites of the genus Plasmodium and transmitted by female anopheline mosquitoes, is one of the most important infectious diseases of humans. The 2012 WHO (World Health Organization...

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Redox signal regulation via nNOS phosphorylation at Ser 847 in PC12 cells and rat cerebellar granule neurons

Shingo Kasamatsu, Yasuo Watanabe, Tomohiro Sawa, Takaaki Akaike, Hideshi Ihara

Biochem J (2014) 459 (2): 251–263.

DOI: https://doi.org/10.1042/BJ20131262

Published: 28 March 2014

...) neuroprotection 8-nitro-cGMP phosphorylation redox signalling reactive oxygen species (ROS) PC12 cells were maintained in RPMI 1640 medium supplemented with 5% (v/v) FBS, 5% (v/v) HS and 1% (v/v) penicillin/streptomycin in a humidified atmosphere at 37°C. Cells were plated at a density of 3.0×10 5...

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Peroxiredoxin-5 targeted to the mitochondrial intermembrane space attenuates hypoxia-induced reactive oxygen species signalling

Simran S. Sabharwal, Gregory B. Waypa, Jeremy D. Marks, Paul T. Schumacker

Biochem J (2013) 456 (3): 337–346.

DOI: https://doi.org/10.1042/BJ20130740

Published: 22 November 2013

... hypoxia-induced cellular responses. hypoxia hypoxia-inducible factor (HIF) hypoxic pulmonary vasoconstriction peroxiredoxin-5 reactive oxygen species (ROS) redox-sensitive GFP (roGFP) Adaptation to low levels of oxygen (hypoxia) is critical for survival, as all multicellular organisms...

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ROS inhibitor N-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors

Marianna Halasi, Ming Wang, Tanmay S. Chavan, Vadim Gaponenko, Nissim Hay, Andrei L. Gartel

Biochem J (2013) 454 (2): 201–208.

DOI: https://doi.org/10.1042/BJ20130282

Published: 09 August 2013

... Biochemical Society 2013 catalase Forkhead box protein M1 (FOXM1) N -acetyl- L -cysteine (NAC) reactive oxygen species (ROS) proteasome inhibitor Both proteasome inhibitors and ROS (reactive oxygen species) inducers are important emerging classes of anticancer drugs. In general, proteasome...

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Functional comparison of Deinococcus radiodurans Dps proteins suggests distinct in vivo roles

Brian J. Reon, Khoa H. Nguyen, Gargi Bhattacharyya, Anne Grove

Biochem J (2012) 447 (3): 381–391.

DOI: https://doi.org/10.1042/BJ20120902

Published: 05 October 2012

... repair pathways, recombination events facilitated by its ring-like nucleoid or accumulation of Mn(II) [ 4 – 11 ]. Deinococcus radiodurans DNA protection during starvation (Dps) ferroxidase activity green fluorescent protein (GFP) nucleoid organization reactive oxygen species (ROS) DNA...

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Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components

Masato Ogura, Junko Yamaki, Miwako K. Homma, Yoshimi Homma

Biochem J (2012) 447 (2): 281–289.

DOI: https://doi.org/10.1042/BJ20120509

Published: 26 September 2012

... the original work is properly cited. cell death energy metabolism mitochondrion Src tyrosine kinase reactive oxygen species (ROS) Mitochondrial serine/threonine phosphorylation has been investigated in terms of the mitochondrial compartments in which it occurs, and the results...

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Myostatin is a novel tumoral factor that induces cancer cachexia

Sudarsanareddy Lokireddy, Isuru Wijerupage Wijesoma, Sabeera Bonala, Meng Wei, Siu Kwan Sze, Craig McFarlane, Ravi Kambadur, Mridula Sharma

Biochem J (2012) 446 (1): 23–36.

DOI: https://doi.org/10.1042/BJ20112024

Published: 27 July 2012

..., distribution and reproduction in any medium, provided the original work is properly cited. activin receptor type II B autophagy–lysosome system myostatin nuclear factor κB (NF-κB) reactive oxygen species (ROS) skeletal muscle wasting tumoral factor ubiquitin–proteasome system Cachexia...

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A key role for Mg 2+ in TRPM7's control of ROS levels during cell stress

Hsiang-Chin Chen, Li-Ting Su, Omayra González-Pagán, Jeffrey D. Overton, Loren W. Runnels

Biochem J (2012) 445 (3): 441–448.

DOI: https://doi.org/10.1042/BJ20120248

Published: 13 July 2012

... correspondence should be addressed (email runnellw@umdnj.edu ). 8 2 2012 27 4 2012 15 5 2012 15 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 apoptosis cell stress Mg 2+ reactive oxygen species (ROS) transient receptor potential melastatin 7...

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Ligand-activated PPARδ inhibits UVB-induced senescence of human keratinocytes via PTEN-mediated inhibition of superoxide production

Sun Ah Ham, Jung Seok Hwang, Taesik Yoo, Hanna Lee, Eun Sil Kang, Chankyu Park, Jae-Wook Oh, Hoon Taek Lee, Gyesik Min, Jin-Hoi Kim, Han Geuk Seo

Biochem J (2012) 444 (1): 27–38.

DOI: https://doi.org/10.1042/BJ20111832

Published: 26 April 2012

... compilation © 2012 Biochemical Society 2012 peroxisome-proliferator-activated receptor δ (PPARδ) phosphatase and tensin homologue deleted on chromosome 10 (PTEN) phosphatidylinositol 3-kinase (PI3K) senescence reactive oxygen species (ROS) UVB Cellular senescence is the permanent...

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CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G 1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells

Ke Gong, Jia Xie, Hong Yi, Wenhua Li

Biochem J (2012) 443 (3): 735–746.

DOI: https://doi.org/10.1042/BJ20111685

Published: 16 April 2012

... proliferation inhibition reactive oxygen species (ROS) Leukaemia, also known as blood cancer, is characterized by rapid cell proliferation and abnormal cell function and is a lethal disease of the bone marrow and blood. It is usually categorized into four main types, acute myeloid leukaemia, chronic...

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Lipocalin-type prostaglandin D synthase protects against oxidative stress-induced neuronal cell death

Ayano Fukuhara, Mao Yamada, Ko Fujimori, Yuya Miyamoto, Toshihide Kusumoto, Hidemitsu Nakajima, Takashi Inui

Biochem J (2012) 443 (1): 75–84.

DOI: https://doi.org/10.1042/BJ20111889

Published: 14 March 2012

... 1 2012 16 1 2012 16 1 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 apoptosis lipocalin neuroprotection prostaglandin D synthase reactive oxygen species (ROS) SH-SY5Y Oxidative stress induced by the excessive production of ROS (reactive...

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Regulation by mitochondrial superoxide and NADPH oxidase of cellular formation of nitrated cyclic GMP: potential implications for ROS signalling

Khandaker Ahtesham Ahmed, Tomohiro Sawa, Hideshi Ihara, Shingo Kasamatsu, Jun Yoshitake, Md. Mizanur Rahaman, Tatsuya Okamoto, Shigemoto Fujii, Takaaki Akaike

Biochem J (2012) 441 (2): 719–730.

DOI: https://doi.org/10.1042/BJ20111130

Published: 21 December 2011

...@gpo.kumamoto-u.ac.jp ). 24 6 2011 3 10 2011 4 10 2011 4 10 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 mitochondrion nitric oxide oxidative stress peroxynitrite reactive oxygen species (ROS) reactive oxygen species (ROS) signalling...

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The mitochondrial citrate carrier: a new player in inflammation

Vittoria Infantino, Paolo Convertini, Liana Cucci, Maria Antonietta Panaro, Maria Antonietta Di Noia, Rosa Calvello, Ferdinando Palmieri, Vito Iacobazzi

Biochem J (2011) 438 (3): 433–436.

DOI: https://doi.org/10.1042/BJ20111275

Published: 26 August 2011

... carrier (CIC) gene regulation immune cell nitric oxide (NO) prostaglandin E 2 reactive oxygen species (ROS) Inflammation is an immune response to infection, tissue injury and other noxious insults [ 1 ]. It is characterized by the production of inflammatory mediators such as cytokines, PGE 2...

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New spectroscopic and electrochemical insights on a class I superoxide reductase: evidence for an intramolecular electron-transfer pathway

Filipe Folgosa, Cristina M. Cordas, Joana A. Santos, Alice S. Pereira, José J. G. Moura, Pedro Tavares, Isabel Moura

Biochem J (2011) 438 (3): 485–494.

DOI: https://doi.org/10.1042/BJ20110836

Published: 26 August 2011

... reactive oxygen species (ROS) superoxide reductase This capability has enormous biological relevance if we consider that the majority of these SOR proteins were first purified from anaerobes, giving them the skills to survive in small amounts of both oxygen and its reaction products [ 7 , 9...

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Phosphoinositide 3-kinase signalling pathway involvement in a truncated apoptotic cascade associated with motility loss and oxidative DNA damage in human spermatozoa

Adam J. Koppers, Lisa A. Mitchell, Ping Wang, Minjie Lin, R. John Aitken

Biochem J (2011) 436 (3): 687–698.

DOI: https://doi.org/10.1042/BJ20110114

Published: 27 May 2011

... phosphoinositide 3-kinase (PI3K) reactive oxygen species (ROS) spermatozoon The formation of 8OHdG was measured using a specific antibody (Biotrin OxyDNA Test Kit, Biotrin International) conjugated to FITC. For the positive control, spermatozoa were incubated for 1 h with H 2 O 2 (2 mM) and FeCl 2 ·4H 2...

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Regulation of mitochondrial metabolism: yet another facet in the biology of the oncoprotein Bcl-2

Shefali Krishna, Ivan Cherh Chiet Low, Shazib Pervaiz

Biochem J (2011) 435 (3): 545–551.

DOI: https://doi.org/10.1042/BJ20101996

Published: 13 April 2011

... and death signalling. 1 To whom correspondence should be addressed (email phssp@nus.edu.sg ). 29 11 2010 10 2 2011 11 2 2011 apoptosis B-cell lymphocytic-leukaemia proto-oncogene 2 (Bcl-2) mitochondrion reactive oxygen species (ROS) The role of mitochondria...

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SUMO2 and SUMO3 transcription is differentially regulated by oxidative stress in an Sp1-dependent manner

Jing Sang, Kai Yang, Yueping Sun, Yan Han, Hui Cang, Yuying Chen, Guiying Shi, Kangmin Wang, Jie Zhou, Xiangrui Wang, Jing Yi

Biochem J (2011) 435 (2): 489–498.

DOI: https://doi.org/10.1042/BJ20101474

Published: 29 March 2011

... Journal compilation © 2011 Biochemical Society 2011 promoter analysis reactive oxygen species (ROS) small ubiquitin-related modifier 2/3 (SUMO2/3) specificity protein 1 (Sp1) transcription RT–PCR and Q-PCR were carried out using standard procedures. After denaturation at 95 °C for 5 min...

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p38 MAPK /p53 signalling axis mediates neuronal apoptosis in response to tetrahydrobiopterin-induced oxidative stress and glucose uptake inhibition: implication for neurodegeneration

Simone Cardaci, Giuseppe Filomeni, Giuseppe Rotilio, Maria R. Ciriolo

Biochem J (2010) 430 (3): 439–451.

DOI: https://doi.org/10.1042/BJ20100503

Published: 27 August 2010

...@bio.uniroma2.it ). 6 4 2010 17 6 2010 30 6 2010 30 6 2010 apoptosis glucose glutathione mitogen-activated protein kinase (MAPK) p53 reactive oxygen species (ROS) Total protein extracts were obtained as previously described [ 27 ]. Protein extracts were then separated...

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What does the commonly used DCF test for oxidative stress really show?

Markus Karlsson, Tino Kurz, Ulf T. Brunk, Sven E. Nilsson, Christina I. Frennesson

Biochem J (2010) 428 (2): 183–190.

DOI: https://doi.org/10.1042/BJ20100208

Published: 13 May 2010

... be addressed (email ulf.brunk@liu.se ). 5 2 2010 22 3 2010 23 3 2010 23 3 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 age-related macular degeneration (AMD) 2′,7′-dichlorofluorescein (DCF) lysosome oxidative stress reactive oxygen species (ROS...

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Extracellular redox status regulates Nrf2 activation through mitochondrial reactive oxygen species

Barry R. Imhoff, Jason M. Hansen

Biochem J (2009) 424 (3): 491–500.

DOI: https://doi.org/10.1042/BJ20091286

Published: 10 December 2009

... 25 9 2009 25 9 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 cysteine nuclear factor-erythroid 2-related factor 2 (Nrf2) reactive oxygen species (ROS) redox thiol thioredoxin Previous studies have highlighted the independence of different thiol...

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Inositol pyrophosphates modulate hydrogen peroxide signalling

Sara Maria Nancy Onnebo, Adolfo Saiardi

Biochem J (2009) 423 (1): 109–118.

DOI: https://doi.org/10.1042/BJ20090241

Published: 14 September 2009

... inositol hexakisphosphate kinase (IP6K) Kcs1 metabolism Rad53 reactive oxygen species (ROS) Inositol pyrophosphates in both lower eukaryotes such as yeast as well as mammalian cells are generated by the sequential phosphorylation of IP 3 (inositol trisphosphate) [ 1 , 2 ] ( Figure 1...

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Interaction of mitochondrial thioredoxin with glucocorticoid receptor and NF-κB modulates glucocorticoid receptor and NF-κB signalling in HEK-293 cells

Anna-Maria G. Psarra, Stefan Hermann, George Panayotou, Giannis Spyrou

Biochem J (2009) 422 (3): 521–531.

DOI: https://doi.org/10.1042/BJ20090107

Published: 27 August 2009

... nuclear factor κB (NF-κB) reactive oxygen species (ROS) thioredoxin transcription For the construction of the expression plasmid for GST–Trx2, the DNA fragment encoding human Trx2, without the mitochondrial signal (nucleotides 181–501), was amplified by PCR and ligated in frame into the pGEX4T...

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Mitochondrial calcium overload triggers complement-dependent superoxide-mediated programmed cell death in Trypanosoma cruzi

Florencia Irigoín, Natalia M. Inada, Mariana P. Fernandes, Lucía Piacenza, Fernanda R. Gadelha, Anibal E. Vercesi, Rafael Radi

Biochem J (2009) 418 (3): 595–604.

DOI: https://doi.org/10.1042/BJ20081981

Published: 25 February 2009

.... 1 Present address: Laboratorio de Biofotonica, Instituto de Física, Universidade de São Paulo, São Carlos, Brazil. 2 To whom correspondence should be addressed (email rradi@fmed.edu.uy ). apoptosis membrane attack complex (MAC) oxidative phosphorylation reactive oxygen species (ROS...

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How mitochondria produce reactive oxygen species

Michael P. Murphy

Biochem J (2009) 417 (1): 1–13.

DOI: https://doi.org/10.1042/BJ20081386

Published: 12 December 2008

...://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. complex I hydrogen peroxide mitochondrion reactive oxygen species (ROS) respiratory chain superoxide Mitochondria...

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Plant plasma membrane water channels conduct the signalling molecule H 2 O 2

Marek Dynowski, Gabriel Schaaf, Dominique Loque, Oscar Moran, Uwe Ludewig

Biochem J (2008) 414 (1): 53–61.

DOI: https://doi.org/10.1042/BJ20080287

Published: 29 July 2008

... constant. aquaglyceroporins aquaporin hydrogen peroxide reactive oxygen species (ROS) Water channels, aquaporins, have been identified in most organisms, including plants, and have specific physiological functions related to water facilitation in many tissues [ 1 – 3 ]. Aquaporins...

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A role for actin in regulating apoptosis/programmed cell death: evidence spanning yeast, plants and animals

Vernonica E. Franklin-Tong, Campbell W. Gourlay

Biochem J (2008) 413 (3): 389–404.

DOI: https://doi.org/10.1042/BJ20080320

Published: 15 July 2008

.... 1 To whom correspondence should be addressed ( C.W.Gourlay@kent.ac.uk ). 8 2 2008 9 5 2008 13 5 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 actin apoptosis mitochondrion programmed cell death (PCD) reactive oxygen species (ROS...

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Protein stability and aggregation in Parkinson's disease

Philip A. Robinson

Biochem J (2008) 413 (1): 1–13.

DOI: https://doi.org/10.1042/BJ20080295

Published: 12 June 2008

..., suggesting that a charged group at this position promotes inclusion formation and may potentially cause further processing of α-synuclein [ 44 ]. chaperone mitochondrion Parkinson's disease reactive oxygen species (ROS) ubiquitin Figure 1 Molecular mechanisms underlying the development...

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NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation

Lena Serrander, Laetitia Cartier, Karen Bedard, Botond Banfi, Bernard Lardy, Olivier Plastre, Andrzej Sienkiewicz, Lászlo Fórró, Werner Schlegel, Karl-Heinz Krause

Biochem J (2007) 406 (1): 105–114.

DOI: https://doi.org/10.1042/BJ20061903

Published: 26 July 2007

... and transferred into a pDEST 30 vector carrying a tet-on CMV (cytomegalovirus) promoter using the Gateway cloning system, according to the manufacturer's instructions. hydrogen peroxide NADPH oxidase (NOX) NOX4 NOX4 inhibitor reactive oxygen species (ROS) superoxide NOX4 is a member...

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The iron-responsive element (IRE)/iron-regulatory protein 1 (IRP1)–cytosolic aconitase iron-regulatory switch does not operate in plants

Nicolas Arnaud, Karl Ravet, Andrea Borlotti, Brigitte Touraine, Jossia Boucherez, Cécile Fizames, Jean-François Briat, Françoise Cellier, Frédéric Gaymard

Biochem J (2007) 405 (3): 523–531.

DOI: https://doi.org/10.1042/BJ20061874

Published: 13 July 2007

... iron in a non-toxic and bioavailable form [ 3 ]. Arabidopsis thaliana cytosolic aconitase ferritin iron homoeostasis iron-regulatory protein 1 (IRP1) reactive oxygen species (ROS) A major regulatory pathway of iron homoeostasis in multicellular eukaryotic organisms has been documented...

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Mechanism of short-term ERK activation by electromagnetic fields at mobile phone frequencies

Joseph Friedman, Sarah Kraus, Yirmi Hauptman, Yoni Schiff, Rony Seger

Biochem J (2007) 405 (3): 559–568.

DOI: https://doi.org/10.1042/BJ20061653

Published: 13 July 2007

... factor (Hb-EGF) matrix metalloproteinase (MMP) mobile phone irradiation NADH oxidase reactive oxygen species (ROS) The intensive use of mobile or cellular phones in the last 20 years has aroused concern about possible health problems that may be caused by the microwave irradiation which...

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Activation of NADPH oxidase by transforming growth factor-β in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-κB-dependent mechanism

Miguel M. Murillo, Irene Carmona-Cuenca, Gaelle del Castillo, Conrad Ortiz, César Roncero, Aránzazu Sánchez, Margarita Fernández, Isabel Fabregat

Biochem J (2007) 405 (2): 251–259.

DOI: https://doi.org/10.1042/BJ20061846

Published: 27 June 2007

... per mg of protein. © 2007 Biochemical Society 2007 heparin-binding epidermal growth factor-like growth factor (HB-EGF) hepatocyte NADPH oxidase (NOX) nuclear factor-κB (NF-κB) reactive oxygen species (ROS) transforming growth factor (TGF) TGF-β (transforming growth factor-β...

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Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1

Gregg L. Semenza

Biochem J (2007) 405 (1): 1–9.

DOI: https://doi.org/10.1042/BJ20070389

Published: 13 June 2007

...) mitochondrial respiratory chain oxidative phosphorylation reactive oxygen species (ROS) tricarboxylic acid cycle The evolution of multicellular organisms on Earth was dependent upon two critical events. The first event, ∼2.5 billion years ago, was the evolution of organisms that transduced solar...

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Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi : cytoprotective action of mitochondrial iron superoxide dismutase overexpression

Lucía Piacenza, Florencia Irigoín, María Noel Alvarez, Gonzalo Peluffo, Martin C. Taylor, John M. Kelly, Shane R. Wilkinson, Rafael Radi

Biochem J (2007) 403 (2): 323–334.

DOI: https://doi.org/10.1042/BJ20061281

Published: 26 March 2007

...@fmed.edu.uy ). 22 8 2006 5 12 2006 14 12 2006 14 12 2006 The Biochemical Society, London 2007 free radicals mitochondrial superoxide dismutase programmed cell death (PCD) reactive oxygen species (ROS) Trypanosoma cruzi Apoptosis is characterized by a series...

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Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages

Yalin Emre, Corinne Hurtaud, Tobias Nübel, François Criscuolo, Daniel Ricquier, Anne-Marie Cassard-Doulcier

Biochem J (2007) 402 (2): 271–278.

DOI: https://doi.org/10.1042/BJ20061430

Published: 12 February 2007

... 10 2006 The Biochemical Society, London 2007 lipopolysaccharide mitochondria mitogen-activated protein kinase (MAPK) reactive oxygen species (ROS) signalling uncoupling protein 2 (UCP2) Innate immunity, the host's first line of defense against pathogens, relies on many cells...

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Metallothionein isoform 2A expression is inducible and protects against ROS-mediated cell death in rotenone-treated HeLa cells

Fimmie Reinecke, Oksana Levanets, Yolanda Olivier, Roan Louw, Boitumelo Semete, Anne Grobler, Juan Hidalgo, Jan Smeitink, Antonel Olckers, Francois H. Van Der Westhuizen

Biochem J (2006) 395 (2): 405–415.

DOI: https://doi.org/10.1042/BJ20051253

Published: 28 March 2006

... a commercial ELISA as instructed by the manufacturer. apoptosis metallothionein mitochondria NADH:ubiquinone oxidoreductase reactive oxygen species (ROS) rotenone The production of ATP through the process of OXPHOS (oxidative phosphorylation) involves the successive transport of electrons...

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Arsenite induces a cell stress-response gene, RTP801 , through reactive oxygen species and transcription factors Elk-1 and CCAAT/enhancer-binding protein

Lin Lin, Teresa M. Stringfield, Xianglin Shi, Yan Chen

Biochem J (2005) 392 (1): 93–102.

DOI: https://doi.org/10.1042/BJ20050553

Published: 08 November 2005

.../EBP) reactive oxygen species (ROS) RTP801 gene Metals are trace elements that are essential for life. However, certain metals, including arsenic, and their derivatives confer toxic effects on the body, which are manifested in carcinogenesis, neurotoxicity and immunotoxicity [ 1 ]. Two...

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Biochemical dysfunction in heart mitochondria exposed to ischaemia and reperfusion

Giancarlo Solaini, David A. Harris

Biochem J (2005) 390 (2): 377–394.

DOI: https://doi.org/10.1042/BJ20042006

Published: 23 August 2005

... reactive oxygen species (ROS) reperfusion The heart is a pump that converts chemical energy into mechanical work. The power produced by cardiac muscle is generated almost entirely by the oxidation of carbon fuels with oxygen, and to a great extent the fuels are provided by coronary (myocardial...

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Perturbation of actin dynamics induces NF-κB activation in myelomonocytic cells through an NADPH oxidase-dependent pathway

Gaelle KUSTERMANS, Jamel EL BENNA, Jacques PIETTE, Sylvie LEGRAND-POELS

Biochem J (2005) 387 (2): 531–540.

DOI: https://doi.org/10.1042/BJ20041318

Published: 05 April 2005

... result in cyclic shifts in cytoskeletal organization and disorganization. actin cytoskeleton myelomonocytic cells nuclear factor κB (NF-κB) reactive oxygen species (ROS) The cytoskeleton is involved in many aspects of cellular function, such as cell movement [ 1 ], muscle contraction [ 2...

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Functional dichotomy of A20 in apoptotic and necrotic cell death

Peter STORZ, Heike DÖPPLER, Christiane FERRAN, Shane T. GREY, Alex TOKER

Biochem J (2005) 387 (1): 47–55.

DOI: https://doi.org/10.1042/BJ20041443

Published: 22 March 2005

... pstorz@bidmc.harvard.edu ). 23 8 2004 26 10 2004 4 11 2004 4 11 2004 The Biochemical Society, London 2005 A20 apoptosis necrosis nuclear factor κB (NF-κB) oxidative stress reactive oxygen species (ROS) ROS (reactive oxygen species) are metabolic by-products...

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A proteome analysis of the arsenite response in cultured lung cells: evidence for in vitro oxidative stress-induced apoptosis

Andy T. Y. LAU, Qing-Yu HE, Jen-Fu CHIU

Biochem J (2004) 382 (2): 641–650.

DOI: https://doi.org/10.1042/BJ20040224

Published: 24 August 2004

... mass spectrometry (MALDI–TOF-MS) oxidative stress reactive oxygen species (ROS) After treatment with arsenite, LEC extracts were isolated and applied to 2-DE and proteins visualized by silver staining. To minimize gel to gel variation, two-dimensional gels were run three times for each...

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Protein kinase function and glutathionylation

Anthony N. ANSELMO, Melanie H. COBB

Biochem J (2004) 381 (3): e1.

DOI: https://doi.org/10.1042/BJ20040873

Published: 27 July 2004

... 5 2004 26 5 2004 The Biochemical Society, London 2004 glutathione glutathionylation kinase mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase kinase (MEKK1) oxidative stress reactive oxygen species (ROS) 1 To whom correspondence should...

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Reactive oxygen species play no role in the candidacidal activity of the salivary antimicrobial peptide histatin 5

Enno C. I. VEERMAN, Kamran NAZMI, Wim van 't HOF, Jan G. M. BOLSCHER, Alice L. den HERTOG, Arie V. NIEUW AMERONGEN

Biochem J (2004) 381 (2): 447–452.

DOI: https://doi.org/10.1042/BJ20040208

Published: 06 July 2004

... ). 9 2 2004 6 4 2004 26 4 2004 26 4 2004 The Biochemical Society, London 2004 amphipathic Candida dihydroethidium histatin membrane reactive oxygen species (ROS) For one of these peptides in particular, the human salivary peptide histatin 5, a number...

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Dual targeting of yeast catalase A to peroxisomes and mitochondria

Ventsislava Y. PETROVA, Diane DRESCHER, Anna V. KUJUMDZIEVA, Manfred J. SCHMITT

Biochem J (2004) 380 (2): 393–400.

DOI: https://doi.org/10.1042/bj20040042

Published: 01 June 2004

..., protein co-tar- geting, reactive oxygen species (ROS), Saccharomyces cerevisiae. INTRODUCTION In all eukaryotic cells, peroxisomes and mitochondria share a great variety of enzymic reactions that are catalysed by isoenzymes present in both organelles. For some of these enzymes it is known that they can...

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