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Keywords: reactive oxygen species
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Articles
Journal:
Biochemical Journal
Biochem J (2023) 480 (13): 1015–1034.
Published: 07 July 2023
... of the Biochemical Society 2023 calcium signalling homeostasis nitrogen phosphorus potassium reactive oxygen species Nutrients play a very important role in regulating ionic homeostasis in plants. Plants acquire them from the soil in their ionic or compound form rather than their elemental forms...
Articles
Lokesh K. Saini, Manisha Sharma, Barkha Ravi, Soma Ghosh, Sonam Pahuja, Nidhi Singh, Girdhar K. Pandey
Journal:
Biochemical Journal
Biochem J (2023) 480 (9): 555–571.
Published: 28 April 2023
... by Portland Press Limited on behalf of the Biochemical Society 2023 Armadillo protein E3 ligase methyl voilogen oxidative stress plant U-box protein reactive oxygen species Plants are constantly exposed to unfavorable environmental conditions such as abiotic and biotic stress conditions...
Articles
Edwin T. Gibbs, II, Chad A. Lerner, Mark A. Watson, Hoi-Shan Wong, Akos A. Gerencser, Martin D. Brand
Journal:
Biochemical Journal
Biochem J (2023) 480 (5): 363–384.
Published: 15 March 2023
... 2023 © 2023 The Author(s) 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . complex I electron transport chain mitochondria reactive oxygen species...
Articles
Journal:
Biochemical Journal
Biochem J (2021) 478 (10): 1977–1984.
Published: 28 May 2021
..., which are regulated by plant hormones, have been shown to depend on reactive oxygen species metabolism and to be related to mitochondrial retrograde signalling. Here we review the recent outcomes in this field of research and highlight the emerging role of ROS communication between organelles and cell...
Articles
In Collection
Editors' pick of review article highlights published in the Biochemical Journal in 2018 & 2019
,
Seeds
Journal:
Biochemical Journal
Biochem J (2019) 476 (20): 3019–3032.
Published: 28 October 2019
...Christophe Bailly Reactive oxygen species (ROS) are versatile compounds which can have toxic or signalling effects in a wide range living organisms, including seeds. They have been reported to play a pivotal role in the regulation of seed germination and dormancy but their mechanisms of action...
Articles
Journal:
Biochemical Journal
Biochem J (2019) 476 (19): 2835–2850.
Published: 11 October 2019
... CIB1 p38 platelet adhesion and activation reactive oxygen species Mitogen-activated protein kinases (MAPK) are a family of serine/threonine protein kinases that are central mediators of many cellular functions from proliferation to apoptosis. MAPK are activated by a kinase signaling cascade...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2019) 476 (15): 2235–2237.
Published: 15 August 2019
... bioenergetics mitochondria reactive oxygen species The work performed by Goldberg et al. [ 3 ] addresses important issues surrounding BCKA oxidation within mitochondria, however, some important questions remain open. Exogenous bicarbonate was used in the present study to stimulate BCKA metabolism...
Articles
In Collection
Seeds
Christina Schausberger, Thomas Roach, Wolfgang Stöggl, Erwann Arc, William E. Finch-Savage, Ilse Kranner
Journal:
Biochemical Journal
Biochem J (2019) 476 (6): 965–974.
Published: 22 March 2019
... by Portland Press Limited on behalf of the Biochemical Society 2019 abscisic acid Arabidopsis thaliana glutathione reactive oxygen species seed longevity vigour Seeds age during storage and the resulting loss of seed vigour and viability can impact crop yields and sustainable agricultural...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2019) 476 (4): 699–703.
Published: 28 February 2019
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 cell homeostasis iron metabolism metalloenzymes reactive oxygen species Group A Streptococcus (GAS; Streptococcus pyogenes ) is an opportunistic and versatile pathogen that can cause a broad spectrum...
Articles
In Collection
Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019
Journal:
Biochemical Journal
Biochem J (2018) 475 (21): 3451–3470.
Published: 09 November 2018
...Rebecca A. Dewhirst; Stephen C. Fry l -Ascorbate, dehydro- l -ascorbic acid (DHA), and 2,3-diketo- l -gulonate (DKG) can all quench reactive oxygen species (ROS) in plants and animals. The vitamin C oxidation products thereby formed are investigated here. DHA and DKG were incubated aerobically...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2018) 475 (19): 3105–3121.
Published: 12 October 2018
...Ravi Prakash Sanyal; Amol Samant; Vishal Prashar; Hari Sharan Misra; Ajay Saini Superoxide dismutases (SODs, EC 1.15.1.1) belong to an important group of antioxidant metalloenzymes. Multiple SODs exist for scavenging of reactive oxygen species (ROS) in different cellular compartments to maintain...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (16): 2713–2731.
Published: 02 August 2017
... and meta-analysis of literature data referring to neurodegenerative and other disorders. Reactive oxygen species (ROS) [ 3 , 4 ] is a term describing a number of reactive molecules and free radicals that are derived from molecular oxygen. Examples of ROS are the singlet oxygen species, 1 O 2 , (one...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (6): 877–883.
Published: 07 March 2017
...Christine H. Foyer; Alexander V. Ruban; Graham Noctor Concepts of the roles of reactive oxygen species (ROS) in plants and animals have shifted in recent years from focusing on oxidative damage effects to the current view of ROS as universal signalling metabolites. Rather than having two opposing...
Articles
Philip Newsholme, Vinicius Fernandes Cruzat, Kevin Noel Keane, Rodrigo Carlessi, Paulo Ivo Homem de Bittencourt, Jr
Journal:
Biochemical Journal
Biochem J (2016) 473 (24): 4527–4550.
Published: 09 December 2016
... and antioxidative systems of cells and tissues, is a result of over production of oxidative-free radicals and associated reactive oxygen species (ROS). One outcome of excessive levels of ROS is the modification of the structure and function of cellular proteins and lipids, leading to cellular dysfunction including...
Articles
Journal:
Biochemical Journal
Biochem J (2016) 473 (22): 4103–4127.
Published: 10 November 2016
...Dave Speijer Reactive oxygen species (ROS) formation by mitochondria is an incompletely understood eukaryotic process. I proposed a kinetic model [BioEssays (2011) 33 , 88–94] in which the ratio between electrons entering the respiratory chain via FADH 2 or NADH (the F/N ratio) is a crucial...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2016) 473 (21): 3903–3921.
Published: 27 October 2016
... with controls. Moreover, treatment with submaximal concentrations of Ca 2+ -mobilizing hormones markedly increased the levels of mitochondrial reactive oxygen species (ROS) in hepatocytes from alcohol-fed rats, but did not affect ROS levels in controls. The changes in mitochondrial Ca 2+ handling are expected...
Articles
Journal:
Biochemical Journal
Biochem J (2016) 473 (19): 2937–2953.
Published: 27 September 2016
... epigenetics polyamines reactive oxygen species spermine oxidase Polyamines have been implicated in several critical cellular functions. These include nucleic acid and chromatin structure maintenance, ion channel regulation, and protein synthesis. Polyamines also serve as substrates...
Articles
Gary G.A. Silkstone, Rebecca S. Silkstone, Michael T. Wilson, Michelle Simons, Leif Bülow, Kristian Kallberg, Khuanpiroon Ratanasopa, Luca Ronda, Andrea Mozzarelli, Brandon J. Reeder, Chris E. Cooper
Journal:
Biochemical Journal
Biochem J (2016) 473 (19): 3371–3383.
Published: 27 September 2016
... The Author(s) 2016 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . hemoglobin oxidative stress reactive oxygen species Hemoglobin (Hb)-based oxygen carriers...
Articles
Journal:
Biochemical Journal
Biochem J (2016) 473 (15): 2295–2314.
Published: 28 July 2016
... isolated by differential centrifugation. Functional measures usually include indicators of basal and active respiration, reactive oxygen species (ROS) emission, apoptotic protein release and/or calcium uptake. Isolated organelles are also useful for understanding processes of mitophagy, as described below...
Articles
Journal:
Biochemical Journal
Biochem J (2016) 473 (1): 99–107.
Published: 09 December 2015
...Goodwin G. Jinesh; Naomi M. Laing; Ashish M. Kamat Cancer cells are capable of sphere formation (transformation) through reactive oxygen species (ROS) and glycolysis shift. Transformation is linked to tumorigenesis and therapy resistance, hence targeting regulators of ROS and glycolysis...
Articles
Paul T. Manna, Tim S. Munsey, Nada Abuarab, Fangfang Li, Aruna Asipu, Gareth Howell, Alicia Sedo, Wei Yang, Jacqui Naylor, David J. Beech, Lin-Hua Jiang, Asipu Sivaprasadarao
Journal:
Biochemical Journal
Biochem J (2015) 466 (3): 537–546.
Published: 06 March 2015
... ]. Reactive oxygen species (ROS), including H 2 O 2 , play a central role in the immune-mediated β-cell death [ 1 , 2 ]. One mechanism by which ROS brings about cell death begins with nicks in ssDNA and activation of the poly(ADP-ribose) polymerase (PARP)–poly(ADP-ribose) glycohydrolase (PARG) pathway [ 4...
Includes: Supplementary data
Articles
Kyle Bauckman, Edward Haller, Nicholas Taran, Stephanie Rockfield, Abigail Ruiz-Rivera, Meera Nanjundan
Journal:
Biochemical Journal
Biochem J (2015) 466 (2): 401–413.
Published: 20 February 2015
... cells; however, the underlying downstream pathway leading to reduced survival was unclear. Although levels of intracellular iron, ferritin/CD71 protein and reactive oxygen species did not correlate with iron-induced cell survival changes, we identified mitochondrial damage (via TEM) and reduced...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2014) 463 (2): 191–199.
Published: 22 September 2014
.... Mimicking mitochondrial dysfunction using respiratory chain/oxidative phosphorylation inhibitors resulted in enhanced expression and release of FGF21 by muscle cells. The increased production of reactive oxygen species, subsequent induction of p38 MAPK (mitogen-activated protein kinase) and activation...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2014) 457 (2): 361–368.
Published: 20 December 2013
... Biochemical Society 2014 TRPML1 is a lysosomal ion channel permeable to cations, including Fe 2+ . Our data suggest that TRPML1 redistributes Fe 2+ between the lysosomes and the cytoplasm. Loss of TRPML1 leads to production of reactive oxygen species, and to mitochondrial deterioration. iron...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2013) 456 (3): 417–426.
Published: 22 November 2013
...-sensitivity of mitochondrial respiration and lowers coupling efficiency of glucose-stimulated oxidative phosphorylation. These mitochondrial defects coincide with an increased level of ROS (reactive oxygen species), impaired GSIS (glucose-stimulated insulin secretion) and decreased cell viability. Palmitate...
Articles
Mari Sasaki, Akihiro Tojo, Yoshifumi Okochi, Nana Miyawaki, Daisuke Kamimura, Akihito Yamaguchi, Masaaki Murakami, Yasushi Okamura
Journal:
Biochemical Journal
Biochem J (2013) 450 (2): 295–301.
Published: 15 February 2013
... the production of reactive oxygen species through regulation of membrane potential and intracellular pH. H v channels have also been suggested to play a role in sperm physiology in the human. However, the functions of the H v channel at the whole-body level are not fully understood. In the present paper we show...
Includes: Supplementary data
Articles
Kevron Grant, Nicole M. Carey, Miguel Mendoza, John Schulze, Marinus Pilon, Elizabeth A. H. Pilon-Smits, Doug van Hoewyk
Journal:
Biochemical Journal
Biochem J (2011) 438 (2): 325–335.
Published: 12 August 2011
... tolerance to selenate, we propose that selenium toxicity can also be caused by selenate's disruption of glutathione biosynthesis leading to enhanced levels of damaging ROS (reactive oxygen species). 1 To whom correspondence should be addressed (email dougvh@coastal.edu ). 4 1 2011 10 5...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2011) 437 (2): 301–311.
Published: 28 June 2011
...Ryan J. Mailloux; Tyler Dumouchel; Céline Aguer; Rob deKemp; Rob Beanlands; Mary-Ellen Harper UCP3 (uncoupling protein-3) mitigates mitochondrial ROS (reactive oxygen species) production, but the mechanisms are poorly understood. Previous studies have also examined UCP3 effects, including decreased...
Includes: Multimedia, Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2011) 435 (3): 679–688.
Published: 13 April 2011
... activity of complex I; conversely H89, a specific PKA inhibitor, suppressed these cAMP-dependent activations. Furthermore, in the present paper we report a 3-fold increase in cellular levels of ROS (reactive oxygen species), in particular superoxide anion, mainly produced by DS-HSF mitochondria. ROS...
Includes: Supplementary data
Articles
Chandi C. Mandal, Suthakar Ganapathy, Yves Gorin, Kalyankar Mahadev, Karen Block, Hanna E. Abboud, Stephen E. Harris, Goutam Ghosh-Choudhury, Nandini Ghosh-Choudhury
Journal:
Biochemical Journal
Biochem J (2011) 433 (2): 393–402.
Published: 22 December 2010
... and mineralized bone nodule formation in mouse 2T3 pre-osteoblasts. BMP-2 elicited a rapid generation of ROS (reactive oxygen species) concomitant with increased activation of NAD(P)H oxidase. NAC and DPI inhibited BMP-2-induced ROS production and NAD(P)H oxidase activity respectively. NAD(P)H oxidases display...
Includes: Supplementary data
Articles
Katja Lehmann, Jörg P. Müller, Bernhard Schlott, Philipp Skroblin, Dagmar Barz, Johannes Norgauer, Reinhard Wetzker
Journal:
Biochemical Journal
Biochem J (2009) 419 (3): 603–610.
Published: 14 April 2009
...Katja Lehmann; Jörg P. Müller; Bernhard Schlott; Philipp Skroblin; Dagmar Barz; Johannes Norgauer; Reinhard Wetzker Neutrophils release reactive oxygen species (ROS) as part of the innate inflammatory immune response. Phosphoinositide 3-kinase γ (PI3Kγ), which is induced by the bacterial peptide N...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2008) 416 (1): 55–63.
Published: 28 October 2008
...Wei Chen; Wei Hao Shang; Yoshifumi Adachi; Kunitaka Hirose; David M. Ferrari; Tohru Kamata Emerging evidence indicates that Nox (NADPH oxidase) 1-generated ROS (reactive oxygen species) play critical regulatory roles in various cellular processes, yet little is known of direct targets...
Articles
Yukio Nisimoto, Ryoko Tsubouchi, Becky A. Diebold, Shanlou Qiao, Hisamitsu Ogawa, Takuya Ohara, Minoru Tamura
Journal:
Biochemical Journal
Biochem J (2008) 415 (1): 57–65.
Published: 12 September 2008
... To whom correspondence should be addressed (email nisiio@aichi-med-u.ac.jp ). 4 2 2008 15 5 2008 2 6 2008 2 6 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 Caco-2 cells Nox1 Rac1 reactive oxygen species small GTPase superoxide...
Articles
Journal:
Biochemical Journal
Biochem J (2008) 412 (3): e17–e19.
Published: 28 May 2008
... evidence has emerged that HIF-1α is also responsive to many stimuli under normoxic conditions, including thrombin, growth factors, vasoactive peptides, insulin, lipopolysaccharide and cytokines such as TNF-α (tumour necrosis factor-α), and in many cases reactive oxygen species are involved. One important...
Articles
Journal:
Biochemical Journal
Biochem J (2008) 411 (3): 531–541.
Published: 14 April 2008
...-dependent mechanism of c-Src activation following H/R injury and found that ROS (reactive oxygen species) generated by endosomal Noxs (NADPH oxidases) are critical for this process. Endocytosis following H/R was required for the activation of endosomal Noxs, c-Src activation, and the ability of c-Src...
Articles
Journal:
Biochemical Journal
Biochem J (2008) 411 (1): 191–199.
Published: 13 March 2008
... 4 12 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 H 2 O 2 molecular chaperone oxidative stress peroxidatic cysteine peroxiredoxin IV (Prx IV) reactive oxygen species Exposure to ROS (reactive oxygen species) has long been recognized as a major...
Articles
Journal:
Biochemical Journal
Biochem J (2007) 407 (2): 255–266.
Published: 25 September 2007
... Society 2007 lipid phosphatase phosphoinositide 3-kinase (PI3K) protein phosphatase reactive oxygen species PIs (phosphoinositides) play a central role in intracellular signalling, acting as substrates for phospholipase C or PI3K (PI 3-kinase), but also by recruiting or regulating...
Articles
Journal:
Biochemical Journal
Biochem J (2007) 406 (2): 215–221.
Published: 13 August 2007
... demonstrated that morphine suppressed DOX-induced inhibition of cell proliferation and programmed cell death in a concentration-dependent, and naloxone as well as pertussis toxin-irreversible, manner. Further studies showed that morphine inhibited ROS (reactive oxygen species) generation, and prevented DOX...
Articles
Journal:
Biochemical Journal
Biochem J (2007) 406 (1): 77–83.
Published: 26 July 2007
...Adrien Rossary; Khelifa Arab; Jean-Paul Steghens The strong ROS (reactive oxygen species) production, part of an antioxidant response of human fibroblasts triggered by DHA (docosahexaenoic acid; C 22:6 , n −3 ), served as a model for deciphering the relative contribution of NOX (NADPH oxidase...
Articles
Journal:
Biochemical Journal
Biochem J (2007) 406 (1): 125–129.
Published: 26 July 2007
... transfer hydrogen peroxide production NADH:ubiquinone oxidoreductase (Complex I) reactive oxygen species succinate © The Authors Journal compilation © 2007 Biochemical Society 2007 9 2 2007 24 4 2007 3 5 2007 3 5 2007 Mitochondria are the major site of ROS (reactive...
Articles
Journal:
Biochemical Journal
Biochem J (2007) 405 (3): e5.
Published: 13 July 2007
... (epidermal growth factor) receptor, which is in turn activated by the release of reactive oxygen species. In summary, Friedman et al. [ 3 ] have been able to add UHF radio waves to the stimuli capable of activating ERK1/2, and have elucidated the mechanism by which this occurs. Further work...
Articles
Pedro Iñarrea, Hadi Moini, Derick Han, Daniel Rettori, Ignacio Aguiló, Maria Angeles Alava, María Iturralde, Enrique Cadenas
Journal:
Biochemical Journal
Biochem J (2007) 405 (1): 173–179.
Published: 13 June 2007
... 2006 22 3 2007 30 3 2007 30 3 2007 © 2007 Biochemical Society 2007 1 To whom correspondence should be addressed (email inarrea@unizar.es ). aconitase Cu,Zn-superoxide dismutase (SOD1) disulfide bond mitochondrial intermembrane space reactive oxygen species...
Articles
Journal:
Biochemical Journal
Biochem J (2007) 401 (1): 1–11.
Published: 11 December 2006
... The Biochemical Society, London 2007 antioxidant cancer DNA repair nitric oxide reactive oxygen species In 1996, I co-authored in the Biochemical Journal an article speculating on the role of oxygen radicals and other ‘reactive species’ (RS; defined in the legend to Figure 1 ) in cancer...
Articles
Journal:
Biochemical Journal
Biochem J (2006) 398 (1): 73–82.
Published: 27 July 2006
...Yaw L. Siow; Kathy K. W. Au-Yeung; Connie W. H. Woo; Karmin O Hyperhomocysteinaemia is an independent risk factor for cardiovascular diseases due to atherosclerosis. The development of atherosclerosis involves reactive oxygen species-induced oxidative stress in vascular cells. Our previous study...
Articles
Arun Kumar, Lijo John, Md. Mahmood Alam, Ankit Gupta, Gayatri Sharma, Beena Pillai, Shantanu Sengupta
Journal:
Biochemical Journal
Biochem J (2006) 396 (1): 61–69.
Published: 26 April 2006
... any similarity to the response to H 2 O 2 . We also failed to detect induction of reactive oxygen species in homocysteine- and cysteine-treated cells, using fluorogenic probes. These results indicate that homocysteine- and cysteine-induced growth defect is not due to the oxidative stress. However, we...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2006) 394 (3): 627–634.
Published: 24 February 2006
... regulation of respiration, for reactive oxygen species generation and for a potential role of S-nitrosation in cardioprotection are discussed. 1 To whom correspondence should be addressed (email paul_brookes@urmc.rochester.edu ). 30 8 2005 17 11 2005 30 11 2005 21 12 2005...
Articles
Journal:
Biochemical Journal
Biochem J (2006) 393 (1): 321–329.
Published: 12 December 2005
... The Biochemical Society, London 2006 methionine sulphoxide reductase promoter reactive oxygen species transcriptional start site The overproduction of ROS (reactive oxygen species) can result in various deleterious effects. In order to protect against these harmful ROS, aerobic organisms have...
Articles
Julien Mozo, Gilles Ferry, Aurélie Studeny, Claire Pecqueur, Marianne Rodriguez, Jean A. Boutin, Frédéric Bouillaud
Journal:
Biochemical Journal
Biochem J (2006) 393 (1): 431–439.
Published: 12 December 2005
... membrane potential mitochondria pyruvate reactive oxygen species uncoupling protein (UCP) The CHO cell lines were grown in Ham's F12 (Life Technologies) medium supplemented with 10% self-inactivated bovine foetal serum, penicillin and geneticin at 37 °C with 5% CO 2 . For glucose depletion...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 390 (2): 501–511.
Published: 23 August 2005
... of 100 μM ADP was depleted. The ADP/O ratio was calculated from the amount of oxygen ( x ) consumed during state 3 respiration: [ADP]/( x ×2). cytochrome c oxidase Drosophila melanogaster electron transport mitochondria mitochondrial respiration reactive oxygen species 1...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 389 (2): 289–295.
Published: 05 July 2005
... pathogenesis indicate that the D -arabitol concentration rises dramatically as infection progresses, and D -arabitol was shown in an in vitro system to be capable of quenching reactive oxygen species involved in host plant defence reactions. ARD1p may therefore play an important role in carbohydrate metabolism...
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