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Keywords: reactive oxygen species
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Biochem J (2023) 480 (24): 2045–2058.
Published: 18 December 2023
... -selenocystine is reduced by intracellular thiols to produce highly redox-active l -selenocysteine molecules which catalytically oxidize cellular GSH and produces large amounts of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide, resulting in acute depletion of GSH and massive oxidative...
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Biochem J (2023) 480 (13): 1015–1034.
Published: 07 July 2023
... in crop plants as well as preventing environmental damage, including their consequences on human health. calcium signalling homeostasis nitrogen phosphorus potassium reactive oxygen species Plants exhibit several adaptive, developmental as well as metabolic responses under conditions...
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Biochem J (2021) 478 (10): 1977–1984.
Published: 28 May 2021
..., which are regulated by plant hormones, have been shown to depend on reactive oxygen species metabolism and to be related to mitochondrial retrograde signalling. Here we review the recent outcomes in this field of research and highlight the emerging role of ROS communication between organelles and cell...
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Biochem J (2019) 476 (20): 3019–3032.
Published: 28 October 2019
...Christophe Bailly Reactive oxygen species (ROS) are versatile compounds which can have toxic or signalling effects in a wide range living organisms, including seeds. They have been reported to play a pivotal role in the regulation of seed germination and dormancy but their mechanisms of action...
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Biochem J (2019) 476 (19): 2835–2850.
Published: 11 October 2019
... CIB1 p38 platelet adhesion and activation reactive oxygen species Mitogen-activated protein kinases (MAPK) are a family of serine/threonine protein kinases that are central mediators of many cellular functions from proliferation to apoptosis. MAPK are activated by a kinase signaling cascade...
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Biochem J (2019) 476 (15): 2235–2237.
Published: 15 August 2019
... bioenergetics mitochondria reactive oxygen species The work performed by Goldberg et al. [ 3 ] addresses important issues surrounding BCKA oxidation within mitochondria, however, some important questions remain open. Exogenous bicarbonate was used in the present study to stimulate BCKA metabolism...
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In Collection
Seeds
Biochem J (2019) 476 (6): 965–974.
Published: 22 March 2019
... by Portland Press Limited on behalf of the Biochemical Society 2019 abscisic acid Arabidopsis thaliana glutathione reactive oxygen species seed longevity vigour Seeds age during storage and the resulting loss of seed vigour and viability can impact crop yields and sustainable agricultural...
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Biochem J (2019) 476 (4): 699–703.
Published: 28 February 2019
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 cell homeostasis iron metabolism metalloenzymes reactive oxygen species Group A Streptococcus (GAS; Streptococcus pyogenes ) is an opportunistic and versatile pathogen that can cause a broad spectrum...
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Biochem J (2018) 475 (19): 3105–3121.
Published: 12 October 2018
...Ravi Prakash Sanyal; Amol Samant; Vishal Prashar; Hari Sharan Misra; Ajay Saini Superoxide dismutases (SODs, EC 1.15.1.1) belong to an important group of antioxidant metalloenzymes. Multiple SODs exist for scavenging of reactive oxygen species (ROS) in different cellular compartments to maintain...
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Biochem J (2017) 474 (16): 2713–2731.
Published: 02 August 2017
... 2017 free energy of activation neurodegenerative disorders oxidative stress reactive oxygen species singlet oxygen Oxidative stress is known to be an imbalance between the production of free radicals in the human body and the ability of the body to counteract their dangerous effects...
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Biochem J (2017) 474 (6): 877–883.
Published: 07 March 2017
...Christine H. Foyer; Alexander V. Ruban; Graham Noctor Concepts of the roles of reactive oxygen species (ROS) in plants and animals have shifted in recent years from focusing on oxidative damage effects to the current view of ROS as universal signalling metabolites. Rather than having two opposing...
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Biochem J (2016) 473 (24): 4527–4550.
Published: 09 December 2016
... and antioxidative systems of cells and tissues, is a result of over production of oxidative-free radicals and associated reactive oxygen species (ROS). One outcome of excessive levels of ROS is the modification of the structure and function of cellular proteins and lipids, leading to cellular dysfunction including...
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Biochem J (2016) 473 (22): 4103–4127.
Published: 10 November 2016
...Dave Speijer Reactive oxygen species (ROS) formation by mitochondria is an incompletely understood eukaryotic process. I proposed a kinetic model [BioEssays (2011) 33 , 88–94] in which the ratio between electrons entering the respiratory chain via FADH 2 or NADH (the F/N ratio) is a crucial...
Includes: Supplementary data
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Biochem J (2016) 473 (21): 3903–3921.
Published: 27 October 2016
... with controls. Moreover, treatment with submaximal concentrations of Ca 2+ -mobilizing hormones markedly increased the levels of mitochondrial reactive oxygen species (ROS) in hepatocytes from alcohol-fed rats, but did not affect ROS levels in controls. The changes in mitochondrial Ca 2+ handling are expected...
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Biochem J (2016) 473 (19): 2937–2953.
Published: 27 September 2016
... ]. cancer therapy chemoprevention epigenetics polyamines reactive oxygen species spermine oxidase Polyamines have been implicated in several critical cellular functions. These include nucleic acid and chromatin structure maintenance, ion channel regulation, and protein synthesis. Polyamines...
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Biochem J (2016) 473 (15): 2295–2314.
Published: 28 July 2016
... underdeveloped in mammalian cells and in whole-body experimental models. aging calcium signalling exercise exercise training mitochondrial protein import mitochondrial reticulum mitophagy mtDNA muscle disuse p53 PPARγ co-activator-1α (PGC-1α) reactive oxygen species Tfam Tfeb...
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Biochem J (2015) 466 (3): 537–546.
Published: 06 March 2015
.../licenses/by/3.0/ ) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. Reactive oxygen species (ROS) can cause pancreatic β-cell death by activating transient receptor potential (melastatin) 2 (TRPM2) channels. Cell death has been...
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Biochem J (2015) 466 (2): 401–413.
Published: 20 February 2015
... cells; however, the underlying downstream pathway leading to reduced survival was unclear. Although levels of intracellular iron, ferritin/CD71 protein and reactive oxygen species did not correlate with iron-induced cell survival changes, we identified mitochondrial damage (via TEM) and reduced...
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Biochem J (2014) 463 (2): 191–199.
Published: 22 September 2014
.... Mimicking mitochondrial dysfunction using respiratory chain/oxidative phosphorylation inhibitors resulted in enhanced expression and release of FGF21 by muscle cells. The increased production of reactive oxygen species, subsequent induction of p38 MAPK (mitogen-activated protein kinase) and activation...
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Biochem J (2013) 450 (2): 295–301.
Published: 15 February 2013
... the production of reactive oxygen species through regulation of membrane potential and intracellular pH. H v channels have also been suggested to play a role in sperm physiology in the human. However, the functions of the H v channel at the whole-body level are not fully understood. In the present paper we show...
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Biochem J (2011) 438 (2): 325–335.
Published: 12 August 2011
... tolerance to selenate, we propose that selenium toxicity can also be caused by selenate's disruption of glutathione biosynthesis leading to enhanced levels of damaging ROS (reactive oxygen species). 1 To whom correspondence should be addressed (email dougvh@coastal.edu ). 4 1 2011 10 5...
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Biochem J (2009) 419 (3): 603–610.
Published: 14 April 2009
...Katja Lehmann; Jörg P. Müller; Bernhard Schlott; Philipp Skroblin; Dagmar Barz; Johannes Norgauer; Reinhard Wetzker Neutrophils release reactive oxygen species (ROS) as part of the innate inflammatory immune response. Phosphoinositide 3-kinase γ (PI3Kγ), which is induced by the bacterial peptide N...
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Biochem J (2008) 416 (1): 55–63.
Published: 28 October 2008
...Wei Chen; Wei Hao Shang; Yoshifumi Adachi; Kunitaka Hirose; David M. Ferrari; Tohru Kamata Emerging evidence indicates that Nox (NADPH oxidase) 1-generated ROS (reactive oxygen species) play critical regulatory roles in various cellular processes, yet little is known of direct targets...
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Biochem J (2008) 415 (1): 57–65.
Published: 12 September 2008
... compilation © 2008 Biochemical Society 2008 Caco-2 cells Nox1 Rac1 reactive oxygen species small GTPase superoxide Superoxide and its reaction products (H 2 O 2 , HOCl and OH•) have been reported to play a crucial role in non-phagocytes in a range of physiological processes...
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Biochem J (2008) 412 (3): e17–e19.
Published: 28 May 2008
... evidence has emerged that HIF-1α is also responsive to many stimuli under normoxic conditions, including thrombin, growth factors, vasoactive peptides, insulin, lipopolysaccharide and cytokines such as TNF-α (tumour necrosis factor-α), and in many cases reactive oxygen species are involved. One important...
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Biochem J (2008) 411 (3): 531–541.
Published: 14 April 2008
...-dependent mechanism of c-Src activation following H/R injury and found that ROS (reactive oxygen species) generated by endosomal Noxs (NADPH oxidases) are critical for this process. Endocytosis following H/R was required for the activation of endosomal Noxs, c-Src activation, and the ability of c-Src...
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Biochem J (2008) 411 (1): 191–199.
Published: 13 March 2008
... 4 12 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 H 2 O 2 molecular chaperone oxidative stress peroxidatic cysteine peroxiredoxin IV (Prx IV) reactive oxygen species Exposure to ROS (reactive oxygen species) has long been recognized as a major...
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Biochem J (2007) 406 (1): 77–83.
Published: 26 July 2007
...Adrien Rossary; Khelifa Arab; Jean-Paul Steghens The strong ROS (reactive oxygen species) production, part of an antioxidant response of human fibroblasts triggered by DHA (docosahexaenoic acid; C 22:6 , n −3 ), served as a model for deciphering the relative contribution of NOX (NADPH oxidase...
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Biochem J (2007) 406 (1): 125–129.
Published: 26 July 2007
... Biochemical Society 2007 brain mitochondrion electron transfer hydrogen peroxide production NADH:ubiquinone oxidoreductase (Complex I) reactive oxygen species succinate Mitochondria are the major site of ROS (reactive oxygen species) production in mammalian cells, and superoxide (O 2...
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Biochem J (2007) 405 (3): e5.
Published: 13 July 2007
... (epidermal growth factor) receptor, which is in turn activated by the release of reactive oxygen species. 1 email j.s.c.arthur@dundee.ac.uk . 6 6 2007 8 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 extracellular-signal-regulated kinase (ERK...
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Biochem J (2007) 401 (1): 1–11.
Published: 11 December 2006
... oxide reactive oxygen species Figure 3 The p53 protein has both pro- and anti-oxidant functions ( a ) In the absence of stress or after mild stress, low levels of p53 drive the expression of several genes which encode antioxidant proteins that decrease RS levels. p53 can also facilitate DNA...
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Biochem J (2006) 396 (1): 61–69.
Published: 26 April 2006
... any similarity to the response to H 2 O 2 . We also failed to detect induction of reactive oxygen species in homocysteine- and cysteine-treated cells, using fluorogenic probes. These results indicate that homocysteine- and cysteine-induced growth defect is not due to the oxidative stress. However, we...
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Biochem J (2006) 394 (3): 627–634.
Published: 24 February 2006
... regulation of respiration, for reactive oxygen species generation and for a potential role of S-nitrosation in cardioprotection are discussed. 1 To whom correspondence should be addressed (email paul_brookes@urmc.rochester.edu ). 30 8 2005 17 11 2005 30 11 2005 21 12 2005...
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Biochem J (2006) 393 (1): 321–329.
Published: 12 December 2005
... The Biochemical Society, London 2006 methionine sulphoxide reductase promoter reactive oxygen species transcriptional start site The overproduction of ROS (reactive oxygen species) can result in various deleterious effects. In order to protect against these harmful ROS, aerobic organisms have...
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Biochem J (2005) 390 (2): 501–511.
Published: 23 August 2005
... oxidase Drosophila melanogaster electron transport mitochondria mitochondrial respiration reactive oxygen species The nature of the mechanisms underlying the aging process is presently unclear; however, the age-related deterioration of functions associated with mitochondria has been...