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Keywords: pyroptosis
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Biochem J (2022) 479 (15): 1621–1651.
Published: 05 August 2022
... to treat certain inflammatory skin diseases. Programmes to develop such inhibitors are already underway. In this review, we outline the mechanisms of skin-associated cell death programmes; apoptosis, necroptosis, pyroptosis, NETosis, and the epidermal terminal differentiation programme, cornification. We...
Biochem J (2022) 479 (10): 1103–1119.
Published: 24 May 2022
...Kim Newton; Alexander D. Gitlin Apoptosis, pyroptosis, and necroptosis are distinct forms of programmed cell death that eliminate infected, damaged, or obsolete cells. Many proteins that regulate or are a part of the cell death machinery undergo ubiquitination, a post-translational modification...
Biochem J (2022) 479 (10): 1083–1102.
Published: 24 May 2022
...Ashley Weir; James E. Vince For over 15 years the lytic cell death termed pyroptosis was defined by its dependency on the inflammatory caspase, caspase-1, which, upon pathogen sensing, is activated by innate immune cytoplasmic protein complexes known as inflammasomes. However, this definition...
Biochem J (2022) 479 (7): 867–882.
Published: 19 April 2022
...Elliott M. Bernard; Petr Broz Following detection of pathogen infection and disrupted cellular homeostasis, cells can activate a range of cell death pathways, such as apoptosis, necroptosis and pyroptosis, as part of their defence strategy. The initiation of pro-inflammatory, lytic pyroptosis...
Biochem J (2022) 479 (5): 609–628.
Published: 04 March 2022
... access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis Covid-19 inflammation necroptosis pyroptosis therapeutics On New Years eve 2019, media reports emerged ∼27...
Biochem J (2020) 477 (20): 3923–3934.
Published: 23 October 2020
...Zhou Zhou; Xiuzhen Li; Yisong Qian; Cynthia Liu; Xiaotian Huang; Mingui Fu Pyroptosis is a recently discovered inflammatory form of programmed cell death which is mostly triggered by infection with intracellular pathogens and critically contributes to inflammation. Mitigating pyroptosis may...