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Keywords: protein structure
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Articles
Biochem J (2022) 479 (6): 751–766.
Published: 28 March 2022
... 2022 © 2022 The Author(s) 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . fluorescence phosphorylation protein structure protein–protein...
Includes: Supplementary data
Articles
Biochem J (2022) 479 (2): 207–223.
Published: 28 January 2022
... of the Biochemical Society 2022 bacteriophages endolysin peptidoglycan hydrolase protein structure At the end of the virulent bacteriophage lytic cycle, endolysins are synthesized to degrade the peptidoglycan of the cell wall. This causes bacterial lysis to occur, releasing progeny phages from...
Includes: Supplementary data
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Biochem J (2021) 478 (15): 3015–3024.
Published: 10 August 2021
.... Correspondence: Vladimir N. Uversky ( vuversky@usf.edu ) 28 6 2021 19 7 2021 26 7 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 intrinsically disordered proteins protein conformation protein structure structure–function...
Articles
Biochem J (2021) 478 (14): 2927–2944.
Published: 28 July 2021
... License 4.0 (CC BY) . biofuels cytochrome electron transfer LPMO oxidation–reduction protein structure The production of second-generation biofuels from lignocellulosic waste in a cost-effective manner is a much-sought-after goal of the industrial biotechnology sector [ 1 , 2 ]. One...
Includes: Supplementary data
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Biochem J (2021) 478 (9): 1749–1767.
Published: 10 May 2021
... ) 1 3 2021 6 4 2021 9 4 2021 12 4 2021 catalytic mechanism phospholipase d protein structure substrate recognition X-ray crystallography Phospholipids (PLs) are important biological molecules that play critical roles in the maintenance of cell membrane integrity...
Includes: Supplementary data
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Biochem J (2021) 478 (1): 197–215.
Published: 15 January 2021
.... Shaw ( gshaw1@uwo.ca ) 28 9 2020 3 12 2020 7 12 2020 7 12 2020 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 calcium signaling NMR spectroscopy protein structure Muscular dystrophy is a degenerative...
Articles
Biochem J (2020) 477 (24): 4785–4796.
Published: 24 December 2020
... allostery in the interaction of the Pseudomonas aeruginosa heme binding protein with heme oxygenase . Proc. Natl. Acad. Sci. U.S.A. 114 , 3421 – 3426 10.1073/pnas.1606931114 arabidopsis thaliana crystallography protein structure tetrapyrroles Heme is an essential pigment...
Articles
Biochem J (2020) 477 (17): 3253–3269.
Published: 10 September 2020
... Southwestern Medical Centre in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with EBSCO. bZIP transcription factors carbohydrate binding modules carbohydrate metabolism importin alpha protein structure Figure 2...
Includes: Supplementary data
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Biochem J (2020) 477 (2): 567–581.
Published: 31 January 2020
... with Portland Press and the Biochemical Society. iron metalloprotein Mycobacterium tuberculosis protein structure The gene Rv2633c in Mycobacterium tuberculosis ( Mtb ) is of interest as it is up-regulated within minutes of phagocytosis of Mtb by macrophages during infection [ 1 , 2...
Articles
Biochem J (2020) 477 (2): 491–508.
Published: 31 January 2020
... NMR protein dynamics protein structure Acyl carrier proteins (ACPs) participate in the biosynthesis of fatty acids (FA) and polyketides by tethering intermediates to the enzyme complex [ 1 , 2 ]. In yeast and mammals, ACP is a component of fatty acid synthase, a multifunctional enzyme...
Includes: Supplementary data
Articles
Biochem J (2020) 477 (2): 381–405.
Published: 30 January 2020
... Press Limited on behalf of the Biochemical Society 2020 heme hemophore HmuY porphyromonas gingivalis prevotella intermedia protein structure Periodontal diseases belong to a group of infectious disorders, which are caused by an ecological shift in the microbial composition in the oral...
Includes: Supplementary data
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Biochem J (2019) 476 (21): 3355–3368.
Published: 15 November 2019
... replicates. crystal DNA-binding domain Myb domain protein structure rice blast fungus RNA binding Cell division cycle 5 (Cdc5) is a highly functionally and structurally conserved eukaryotic protein and participates in diverse molecular processes, such as cell cycle, DNA repair, RNA...
Includes: Supplementary data
Articles
Biochem J (2019) 476 (7): 1173–1189.
Published: 15 April 2019
... 25 3 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 Alzheimer's disease amyloid beta computational biochemistry protein structure The 99-residue C-terminal fragment (C99) of the amyloid precursor protein (APP...
Includes: Supplementary data
Articles
Biochem J (2019) 476 (5): 809–826.
Published: 12 March 2019
... spectroscopy plant proteins protein structure Plants express a large number and variety of small, disulfide-bonded, secreted peptides, often acting in defence roles, or in cell signalling. The former group of peptides include plant defensins, thionins, snakins and protease inhibitors, whereas...
Articles
Biochem J (2018) 475 (12): 2043–2055.
Published: 26 June 2018
..., Oxford OX1 3TA, U.K. 17 3 2018 7 5 2018 10 5 2018 14 5 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 drug discovery and design NMR spectroscopy palmitoylation protein structure protein–protein Introduction...
Includes: Supplementary data
Articles
Biochem J (2018) 475 (9): 1533–1551.
Published: 04 May 2018
... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . arabinoxylan GH30 glycoside hydrolase family 30 protein structure structure–function Figure 1. Protein...
Includes: Supplementary data
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Biochem J (2018) 475 (1): 341–354.
Published: 15 January 2018
... 2017 11 12 2017 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 protein conformation protein structure RNA polymerase RpoS Salmonella sigma factor The ability to adapt quickly to variations of environmental conditions...
Includes: Supplementary data
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Biochem J (2018) 475 (1): 247–260.
Published: 05 January 2018
... by Portland Press Limited on behalf of the Biochemical Society 2018 allosteric regulation phosphoribosyltransferase protein structure Allostery is a fundamental mechanism of biological regulation in which ligand binding at one protein site elicits a functional response at another site...
Articles
Biochem J (2017) 474 (14): 2333–2347.
Published: 03 July 2017
... of the Biochemical Society 2017 glycosylation protein function protein stability protein structure Glycosylation is the covalent addition of sugar moieties to the protein co-translationally or as a post-translational modification enzymatically. It is the most frequent, heterogeneous, stereo...
Articles
Biochem J (2017) 474 (13): 2219–2233.
Published: 21 June 2017
... 11 5 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 enzyme activity enzymology molecular evolution protein structure ribonuclease RNA Vertebrate animals possess a distinct, conserved family of secreted ribonucleases...
Includes: Supplementary data
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Biochem J (2017) 474 (13): 2159–2175.
Published: 16 June 2017
... 5 2017 © 2017 The Author(s) 2017 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . adenosine diphosphate ribose protein structure transient receptor...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (24): 4699–4713.
Published: 09 December 2016
...: Maria Scarselli ( maria.x.scarselli@gsk.com ) 29 8 2016 19 10 2016 25 10 2016 26 10 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 fHbp monoclonal antibodies Neisseria protein structure Factor H...
Includes: Supplementary data
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Biochem J (2016) 473 (20): 3705–3724.
Published: 11 October 2016
... folding protein structure solvation Inspection of the resulting trajectories shows that for all systems the unfolding process, illustrated in Figure 1A , follows a common pathway: the protein splits into two globular subdomains, each held together by two disulfide bonds, and interconnected...
Includes: Supplementary data
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Biochem J (2016) 473 (19): 3159–3175.
Published: 27 September 2016
... kinase A protein structure Protein phosphorylation is a reversible post-translational modification (PTM) catalyzed by the protein kinase-mediated enzymatic transfer of ATP γ-phosphate to an appropriate side chain in a substrate [ 1 ]. A plethora of techniques, including X-ray crystallography...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (18): 2763–2782.
Published: 12 September 2016
... 2010, Australia. 28 10 2015 27 6 2016 29 6 2016 30 6 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 crystallography ezrin FERM domain protein dynamics protein structure small-angle scattering...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (8): 1063–1072.
Published: 08 April 2016
... plasmids protein structure Prokaryotes are constantly faced with the threat of viral infection. Viruses that infect bacteria are called bacteriophages (or phages) and are the most abundant biological entities on earth, outnumbering their hosts by at least an order of magnitude [ 1 – 3 ]. The high...
Includes: Supplementary data
Articles
Biochem J (2015) 471 (3): 403–414.
Published: 16 October 2015
... resonance (NMR) parasite protein structure retinol-binding protein X-ray Lipids such as acids (FAs) and retinoids are relatively insoluble in water, can be susceptible to oxidation and are potentially damaging to membranes in their free form. Consequently, they are usually transported within...
Includes: Supplementary data
Articles
Biochem J (2015) 466 (2): 219–232.
Published: 20 February 2015
.... β7 in TbMCA2 is structurally homologous to β5 in the caspases–denoted as H β5 ( H 5; Figure 3 B). caspase clan CD crystallography metacaspase peptidase protein structure Clan CD [ 1 ] cysteine peptidases use an active site cysteine residue to catalyse the hydrolysis...
Includes: Supplementary data
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Biochem J (2014) 463 (2): 297–307.
Published: 22 September 2014
... the bacterial homologues of a medically important family of membrane transporter and propose this continues across this protein family. membrane protein protein purification protein structure Slc26/SulP small-angle neutron scattering transporter The Slc26A proteins are a ubiquitous family...
Includes: Supplementary data
Articles
Biochem J (2014) 459 (1): 59–69.
Published: 14 March 2014
... in complex with specific single chain antibodies (nanobodies) revealed the domain plasticity of this kinase and unusual activation segment architecture. activation loop cyclin G-associated kinase drug side effect kinase inhibitor nanobody protein structure Kinases are highly dynamic...
Includes: Supplementary data
Articles
Biochem J (2014) 457 (1): 33–41.
Published: 10 December 2013
... is characterized with respect to catalytic activity and peptidoglycan binding. catalytic site cell wall Mycobacterium tuberculosis NlpC/p60 peptidoglycan binding proline-rich protein repeat protein structure The cell wall of Mycobacterium tuberculosis has a unique architecture...
Includes: Supplementary data
Articles
Biochem J (2013) 453 (2): 155–166.
Published: 28 June 2013
... cited. antiviral defence cluster of regularly interspaced palindromic repeats (CRISPR) crystallography evolution protein structure repeat-associated mysterious protein (RAMP) CRISPRs (cluster of regularly interspaced palindromic repeats) are a prokaryotic defence mechanism against...
Includes: Supplementary data
Articles
Biochem J (2013) 452 (2): 293–301.
Published: 10 May 2013
... energy transfer (FRET) phospholipid membrane protein structure F (Factor) VIII is a plasma protein that is decreased or defective in individuals with haemophilia A. FVIII circulates as a heterodimer consisting of a HC (heavy chain) comprised of A1, A2 and B domains and a LC (light chain...
Articles
Biochem J (2013) 452 (1): 87–95.
Published: 25 April 2013
... 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 disulfide bond haemojuvelin iron metabolism mass spectrometry molecular modelling protein structure repulsive guidance molecule Iron plays an essential role in human physiology as a cofactor for oxygen...
Includes: Supplementary data
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Biochem J (2012) 448 (3): 329–341.
Published: 21 November 2012
... of 45790 cm −1 ·M −1 and 28360 cm −1 ·M −1 for Ec_ MpaA and Vh_ MpaA respectively. E. coli MppA was purified as described previously [ 15 ]. © The Authors Journal compilation © 2012 Biochemical Society 2012 Escherichia coli murein tripeptide protein structure transporter Vibrio...
Includes: Supplementary data
Articles
Biochem J (2012) 446 (1): 149–157.
Published: 27 July 2012
... as a therapeutic strategy for allergic inflammation and asthma [ 8 – 10 ]. chitinase chitinase-like proteins glycan glycan array glycobiology protein structure lectin X-ray crystallography © 2012 The Author(s) 2012 This is an open-access article distributed under the terms of the Creative...
Articles
Biochem J (2012) 445 (2): 157–166.
Published: 27 June 2012
... Journal compilation © 2012 Biochemical Society 2012 cryo-electron microscopy electron crystallography Helicobacter pylori membrane protein structure urea channel The solute permeability of proteoliposomes containing purified UAC Bc was measured as described by Godara et al. [ 20...
Includes: Supplementary data
Articles
Biochem J (2011) 439 (3): 375–381.
Published: 13 October 2011
... be addressed (email leszek.kleczkowski@plantphys.umu.se ). 26 4 2011 8 7 2011 18 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 oligomerization protein structure sugar activation UDP-sugar synthesis UDP-sugars serve as direct precursors...
Includes: Supplementary data
Articles
Biochem J (2011) 437 (3): 423–430.
Published: 13 July 2011
... olfactory protein protein structure Olfaction is a finely tuned sense, able to detect and discriminate between thousands of volatile molecules at low concentrations, some differing by only one or a few atoms. Olfaction in insects relies on dedicated organs in the antennae, which gather...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2011) 437 (2): 243–253.
Published: 28 June 2011
... recognition, the second subunit provides residues for phosphate binding, and the extended flexible C-terminal end of the third subunit covers the active site with a bound substrate [ 6 ]. dITP dUTP dUTP pyrophosphatase (dUTPase) enzyme co-operativity mutagenesis protein structure Preserving...
Includes: Multimedia, Supplementary data
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Biochem J (2010) 429 (3): 553–563.
Published: 14 July 2010
.... 1 To whom correspondence should be addressed (email jason.young2@mcgill.ca ). 7 12 2009 16 5 2010 26 5 2010 26 5 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 chaperone dimerization heat-shock protein (Hsp) mitochondrion protein...
Includes: Supplementary data
Articles
Biochem J (2010) 426 (3): 281–292.
Published: 24 February 2010
... 2010 Biochemical Society 2010 elongation factor 1A (EF1A) glucosyl transferase Legionella pneumophila microinjection site-directed mutagenesis protein structure Over the past decade several studies have reported fascinating examples of pathogenic bacteria employing...
Includes: Supplementary data
Articles
Biochem J (2009) 421 (1): 87–96.
Published: 12 June 2009
... and this effect is coupled with kinetic stabilization; the bulky polysaccharide chains inhibit formation of a residual structure in the unfolded glycoprotein [ 11 ]. Nevertheless, the analysis of glycosylation sites in the protein structure databases still emphasizes the structural role of glycosylation...
Includes: Supplementary data
Articles
Biochem J (2009) 419 (1): 15–28.
Published: 13 March 2009
... genome protein structure This means we can define two levels of homologous relationships for domains. Domains whose sequences have significant similarities form domain families. Those whose common evolutionary origin are indicated by their structure, function and aspects of sequence form domain...
Articles
Biochem J (2009) 418 (3): 541–551.
Published: 25 February 2009
... region) will appear in the Protein Data Bank under accession code 3FCG. 19 5 2008 3 11 2008 25 11 2008 25 11 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 assembly chaperone/usher pathway fimbrial adhesins protein structure secretion...
Includes: Supplementary data
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Biochem J (2009) 417 (1): 55–64.
Published: 12 December 2008
...@iname.com ). 19 12 2007 19 8 2008 9 9 2008 9 9 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 enzyme activity glutathione transferase (GST) protein folding protein structure GSTs (glutathione transferases; EC 2.5.1.18) are a large family...
Articles
Biochem J (2008) 416 (3): 317–326.
Published: 26 November 2008
... or because the molecular chaperone pathway which is activated by glycation in vivo is absent from a test tube [ 19 , 26 ]. The observed changes in protein structure and stability are related to the glycation-dependent activity loss, 65% inactivation in vivo and 85% activity loss in vitro...
Articles
Biochem J (2008) 415 (2): 217–223.
Published: 25 September 2008
... compilation © 2008 Biochemical Society 2008 Aspergillus fumigatus inhibitor design kinetics mutagenesis protein structure UDP-GlcNAc biosynthesis X-ray crystallography Aspergillus fumigatus is a filamentous, cosmopolitan and ubiquitous saprophytic fungus [ 1 ]. Its natural ecological...
Articles
Biochem J (2008) 411 (3): 485–493.
Published: 14 April 2008
... factor protein–protein interaction protein structure Rho GTPase type III secretion Table 1 Structural statistics on NMR-derived structures of BopE GEF domain The RMSD from the mean structure calculated over residues 83–99, 110–133, 143–156, 177–189, 205–217 and 220–246. Ramachandran plot...
Includes: Supplementary data
Articles
Biochem J (2008) 409 (2): 525–533.
Published: 21 December 2007
... DOCK11 limited proteolysis protein structure zizimin The Rho family of low-molecular-mass GTPases includes 22 human genes, the best known members being RhoA, Rac1 and Cdc42 [ 1 , 2 ]. Rho GTPases control fundamental processes common to all eukaryotes, including morphogenesis, polarity...