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Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease patients

In Collection

Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019

Belén Fernández, Antonio Jesús Lara Ordóñez, Elena Fdez, Eugénie Mutez, Thomas Comptdaer, Coline Leghay, Alexandre Kreisler, Clémence Simonin, Laurine Vandewynckel, Luc Defebvre, Alain Destée, Séverine Bleuse, Jean-Marc Taymans, Marie-Christine Chartier-Harlin, Sabine Hilfiker

Biochem J (2019) 476 (19): 2797–2813.

https://doi.org/10.1042/BCJ20190315

Published: 11 October 2019

... 2019 The Author(s) 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . centrosome cohesion leucine-rich repeat kinase protein phosphorylation Rab...

View article titled, Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease patients

Includes: Supplementary data

Articles

Revisiting paradigms of Ca 2+ signaling protein kinase regulation in plants

In Collection

Editors' pick of review article highlights published in the Biochemical Journal in 2018 & 2019

Kyle W. Bender, Raymond E. Zielinski, Steven C. Huber

Biochem J (2018) 475 (1): 207–223.

https://doi.org/10.1042/BCJ20170022

Published: 05 January 2018

... by Portland Press Limited on behalf of the Biochemical Society 2018 calcium-dependent protein kinase calcium sensor calcium signaling protein phosphorylation Calcium (Ca 2+ ) signaling is a universal mechanism in eukaryotes for the control of many physiological processes. In response...

View article titled, Revisiting paradigms of Ca 2+ signaling protein kinase regulation in plants

Articles

Dual phosphorylation in response regulator protein PrrA is crucial for intracellular survival of mycobacteria consequent upon transcriptional activation

Alok K. Mishra, Shivraj M. Yabaji, Rikesh K. Dubey, Ekta Dhamija, Kishore K. Srivastava

Biochem J (2017) 474 (24): 4119–4136.

https://doi.org/10.1042/BCJ20170596

Published: 06 December 2017

... regulation histidine kinase mycobacteria protein phosphorylation Mycobacterium tuberculosis ( Mtb ) is a successful intracellular pathogen and continues to be one of the leading causes of mortality worldwide [ 1 , 2 ]. Despite extensive tuberculosis management programs, it still accounts...

View article titled, Dual phosphorylation in response regulator protein PrrA is crucial for intracellular survival of mycobacteria consequent upon transcriptional activation

Includes: Supplementary data

Articles

Sphingolipid biosynthesis upregulation by TOR complex 2–Ypk1 signaling during yeast adaptive response to acetic acid stress

Joana F. Guerreiro, Alexander Muir, Subramaniam Ramachandran, Jeremy Thorner, Isabel Sá-Correia

Biochem J (2016) 473 (23): 4311–4325.

https://doi.org/10.1042/BCJ20160565

Published: 25 November 2016

... metabolism protein kinases protein phosphorylation weak acid Correspondence: Isabel Sá-Correia ( isacorreia@tecnico.ulisboa.pt ) or Jeremy Thorner ( jthorner@berkeley.edu ) * These authors contributed equally to this work. Understanding the cellular response to acetic acid stress...

View article titled, Sphingolipid biosynthesis upregulation by TOR complex 2–Ypk1 signaling during yeast adaptive response to acetic acid stress

Articles

The calcium-dependent protein kinase RcCDPK2 phosphorylates sucrose synthase at Ser 11 in developing castor oil seeds

Eric T. Fedosejevs, Suzanne A. Gerdis, Sheng Ying, Michal Pyc, Erin M. Anderson, Wayne A. Snedden, Robert T. Mullen, Yi-Min She, William C. Plaxton

Biochem J (2016) 473 (20): 3667–3682.

https://doi.org/10.1042/BCJ20160531

Published: 11 October 2016

... (metabolism) protein phosphorylation Ricinus communis (castor oil plant) sucrose synthase A pivotal initial step in the biosynthesis of storage end-products by developing seeds is the UDP-dependent conversion of imported photosynthate (i.e., sucrose) into UDP-glucose and fructose, catalyzed...

View article titled, The calcium-dependent protein kinase RcCDPK2 phosphorylates sucrose synthase at Ser 11 in developing castor oil seeds

Includes: Supplementary data

Articles

Design, validation and efficacy of bisubstrate inhibitors specifically affecting ecto-CK2 kinase activity

Giorgio Cozza, Sofia Zanin, Stefania Sarno, Elena Costa, Cristina Girardi, Giovanni Ribaudo, Mauro Salvi, Giuseppe Zagotto, Maria Ruzzene, Lorenzo A. Pinna

Biochem J (2015) 471 (3): 415–430.

https://doi.org/10.1042/BJ20141127

Published: 16 October 2015

... 9 2015 8 9 2015 © 2015 Authors; published by Portland Press Limited 2015 bisubstrate inhibitor cell migration CK2 ecto-kinase protein kinase inhibitor protein phosphorylation signal transduction Protein kinases are implicated in a wide variety of human diseases...

View article titled, Design, validation and efficacy of bisubstrate inhibitors specifically affecting ecto-CK2 kinase activity

Articles

The focal adhesion kinase Pyk2 links Ca 2+ signalling to Src family kinase activation and protein tyrosine phosphorylation in thrombin-stimulated platelets

Ilaria Canobbio, Lina Cipolla, Gianni F. Guidetti, Daria Manganaro, Caterina Visconte, Soochong Kim, Mitsuhiko Okigaki, Marco Falasca, Satya P. Kunapuli, Mauro Torti

Biochem J (2015) 469 (2): 199–210.

https://doi.org/10.1042/BJ20150048

Published: 06 July 2015

... between Pyk2 and the Src kinases Fyn and Lyn in the regulation of Ca 2+ -dependent protein-tyrosine phosphorylation. calcium G protein-coupled receptor (GPCR) platelets protein phosphorylation signal transduction tyrosine kinase thrombin The essential role of blood platelets...

View article titled, The focal adhesion kinase Pyk2 links Ca 2+ signalling to Src family kinase activation and protein tyrosine phosphorylation in thrombin-stimulated platelets

Articles

Phosphorylation of bacterial-type phosphoenolpyruvate carboxylase by a Ca 2+ -dependent protein kinase suggests a link between Ca 2+ signalling and anaplerotic pathway control in developing castor oil seeds

Allyson T. Hill, Sheng Ying, William C. Plaxton

Biochem J (2014) 458 (1): 109–118.

https://doi.org/10.1042/BJ20131191

Published: 20 January 2014

... elicited in response to external stimuli or developmental cues through the activation of protein phosphorylation cascades [ 24 , 33 ]. CDPKs have been implicated in many different aspects of plant biology, from hormone-regulated developmental processes to abiotic and biotic stress signalling, with several...

View article titled, Phosphorylation of bacterial-type phosphoenolpyruvate carboxylase by a Ca 2+ -dependent protein kinase suggests a link between Ca 2+ signalling and anaplerotic pathway control in developing castor oil seeds

Includes: Supplementary data

Articles

SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein–protein interactions

Peter H. Sugden, Liam J. McGuffin, Angela Clerk

Biochem J (2013) 454 (1): 13–30.

https://doi.org/10.1042/BJ20130219

Published: 26 July 2013

... Biochemical Society 2013 cytoskeleton focal adhesion germinal centre kinase III subfamily (GCKIII) Golgi MO25 protein phosphatase 2A (PP2A) protein phosphorylation STRAD (sterile 20-related kinase adaptor α) striatin All three human GCKIII genes consist of 12 exons and are ubiquitously...

View article titled, SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein–protein interactions

Includes: Multimedia, Supplementary data

Articles

Phosphorylation of the guanine-nucleotide-exchange factor CalDAG-GEFI by protein kinase A regulates Ca 2+ -dependent activation of platelet Rap1b GTPase

Gianni Francesco Guidetti, Daria Manganaro, Alessandra Consonni, Ilaria Canobbio, Cesare Balduini, Mauro Torti

Biochem J (2013) 453 (1): 115–123.

https://doi.org/10.1042/BJ20130131

Published: 13 June 2013

... 2013 19 4 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 calcium and diacylglycerol-regulated guanine-nucleotide-exchange factor I (CalDAG-GEFI) cAMP platelet platelet inhibition protein phosphorylation Rap1b signal transduction Integrin α IIb β 3...

View article titled, Phosphorylation of the guanine-nucleotide-exchange factor CalDAG-GEFI by protein kinase A regulates Ca 2+ -dependent activation of platelet Rap1b GTPase

Articles

Eukaryotic initiation factor 5A dephosphorylation is required for translational arrest in stationary phase cells

Janete Chung, Antonio A. Rocha, Renata R. Tonelli, Beatriz A. Castilho, Sergio Schenkman

Biochem J (2013) 451 (2): 257–267.

https://doi.org/10.1042/BJ20121553

Published: 28 March 2013

... Biochemical Society 2013 eukaryotic initiation factor 5A (eIF5A) protein phosphorylation translation initiation factor translation regulation Trypanosoma cruzi eIF5A (eukaryotic initiation factor 5A) is highly conserved and essential in eukaryotic organisms [ 1 , 2 ]. It was originally...

View article titled, Eukaryotic initiation factor 5A dephosphorylation is required for translational arrest in stationary phase cells

Includes: Supplementary data

Articles

Glucan affinity of starch synthase IIa determines binding of starch synthase I and starch-branching enzyme IIb to starch granules

Fushan Liu, Nadya Romanova, Elizabeth A. Lee, Regina Ahmed, Martin Evans, Elliot P. Gilbert, Matthew K. Morell, Michael J. Emes, Ian J. Tetlow

Biochem J (2012) 448 (3): 373–387.

https://doi.org/10.1042/BJ20120573

Published: 21 November 2012

... © The Authors Journal compilation © 2012 Biochemical Society 2012 amyloplast protein phosphorylation protein–protein interaction starch synthase starch-branching enzyme starch synthesis sugary-2 Storage starch produced in cereal endosperms accounts for a significant proportion...

View article titled, Glucan affinity of starch synthase IIa determines binding of starch synthase I and starch-branching enzyme IIb to starch granules

Includes: Supplementary data

Articles

Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor

Hiroyuki Hirai, Peter Karian, Nobuaki Kikyo

Biochem J (2011) 438 (1): 11–23.

https://doi.org/10.1042/BJ20102152

Published: 27 July 2011

... be addressed (email kikyo001@umn.edu ). 22 12 2010 23 3 2011 4 4 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 cell differentiation embryonic stem cell (ESC) kinase inhibitor leukaemia inhibitory factor (LIF) protein phosphorylation signal transducer...

View article titled, Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor

Articles

The remarkable diversity of plant PEPC (phosphoenolpyruvate carboxylase): recent insights into the physiological functions and post-translational controls of non-photosynthetic PEPCs

Brendan O'Leary, Joonho Park, William C. Plaxton

Biochem J (2011) 436 (1): 15–34.

https://doi.org/10.1042/BJ20110078

Published: 27 April 2011

... [ 41 ] and Triticum aestivum (wheat) leaves [ 42 ]. © The Authors Journal compilation © 2011 Biochemical Society 2011 14-3-3 protein mono-ubiquitination phosphoenolpyruvate carboxylase protein phosphorylation protein–protein interaction PEPC [PEP (phosphoenolpyruvate...

View article titled, The remarkable diversity of plant PEPC (phosphoenolpyruvate carboxylase): recent insights into the physiological functions and post-translational controls of non-photosynthetic PEPCs

Articles

Phosphorylation of bacterial-type phosphoenolpyruvate carboxylase at Ser 425 provides a further tier of enzyme control in developing castor oil seeds

Brendan O'Leary, Srinath K. Rao, William C. Plaxton

Biochem J (2011) 433 (1): 65–74.

https://doi.org/10.1042/BJ20101361

Published: 15 December 2010

... that BTPC's phospho-Ser 425 content depends upon COS developmental and physiological status and that Ser 425 phosphorylation attenuates the catalytic activity of BTPC subunits within a Class-2 PEPC complex. To the best of our knowledge, this study provides the first evidence for protein phosphorylation...

View article titled, Phosphorylation of bacterial-type phosphoenolpyruvate carboxylase at Ser 425 provides a further tier of enzyme control in developing castor oil seeds

Includes: Supplementary data

Articles

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser 910 /Ser 935 , disruption of 14-3-3 binding and altered cytoplasmic localization

Nicolas Dzamko, Maria Deak, Faycal Hentati, Alastair D. Reith, Alan R. Prescott, Dario R. Alessi, R. Jeremy Nichols

Biochem J (2010) 430 (3): 405–413.

https://doi.org/10.1042/BJ20100784

Published: 27 August 2010

..., but 32-fold less sensitive to H-1152 and 12-fold less sensitive to sunitinib [ 8 ]. cell-based assay drug discovery 14-3-3 protein kinase inhibitor leucine-rich repeat protein kinase 2 (LRRK2) Parkinson's disease protein phosphorylation Autosomal dominant missense mutations within...

View article titled, Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser 910 /Ser 935 , disruption of 14-3-3 binding and altered cytoplasmic localization

Includes: Supplementary data

Articles

C-terminal domain phosphorylation of ERK3 controlled by Cdk1 and Cdc14 regulates its stability in mitosis

Pierre-Luc Tanguay, Geneviève Rodier, Sylvain Meloche

Biochem J (2010) 428 (1): 103–111.

https://doi.org/10.1042/BJ20091604

Published: 28 April 2010

... 2010 cell cycle extracellular-signal-regulated kinase 3 (ERK3) mitogen-activated protein kinase (MAPK) mitosis protein phosphorylation ERK3 (extracellular-signal-regulated kinase 3) is an atypical member of the MAPK (mitogen-activated protein kinase) family of serine/threonine protein...

View article titled, C-terminal domain phosphorylation of ERK3 controlled by Cdk1 and Cdc14 regulates its stability in mitosis

Includes: Supplementary data

Articles

The DNA-binding activity of mouse DNA methyltransferase 1 is regulated by phosphorylation with casein kinase 1δ/ε

Yasunori Sugiyama, Naoya Hatano, Noriyuki Sueyoshi, Isao Suetake, Shoji Tajima, Eiji Kinoshita, Emiko Kinoshita-Kikuta, Tohru Koike, Isamu Kameshita

Biochem J (2010) 427 (3): 489–497.

https://doi.org/10.1042/BJ20091856

Published: 14 April 2010

... into CK1 from that into CK1 plus GST–Dnmt1(1–290). 1 To whom correspondence should be addressed (email kamesita@ag.kagawa-u.ac.jp ). casein kinase 1 (CK1) DNA-binding activity DNA methylation DNA methyltransferase domain structure protein phosphorylation In mammals, the fifth...

View article titled, The DNA-binding activity of mouse DNA methyltransferase 1 is regulated by phosphorylation with casein kinase 1δ/ε

Articles

Oxidation of methionine residues: the missing link between stress and signalling responses in plants

Michael J. Emes

Biochem J (2009) 422 (2): e1–e2.

https://doi.org/10.1042/BJ20091063

Published: 13 August 2009

...Michael J. Emes In response to biotic and abiotic stresses, plants induce a complex array of pathways and protein phosphorylation cascades which generally lead to a response aimed at mitigating the particular insult. In many cases, H 2 O 2 has been implicated as the signalling molecule...

View article titled, Oxidation of methionine residues: the missing link between stress and signalling responses in plants

Articles

In vivo regulatory phosphorylation of the phosphoenolpyruvate carboxylase AtPPC1 in phosphate-starved Arabidopsis thaliana

Allison L. Gregory, Brenden A. Hurley, Hue T. Tran, Alexander J. Valentine, Yi-Min She, Vicki L. Knowles, William C. Plaxton

Biochem J (2009) 420 (1): 57–65.

https://doi.org/10.1042/BJ20082397

Published: 28 April 2009

...-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. Arabidopsis gene expression P i starvation mass spectrometry phosphoenolpyruvate carboxylase kinase (PPCK) protein phosphorylation PEPC [PEP (phosphoenolpyruvate) carboxylase] (EC...

View article titled, In vivo regulatory phosphorylation of the phosphoenolpyruvate carboxylase AtPPC1 in phosphate-starved Arabidopsis thaliana

Includes: Supplementary data

Articles

Dsk1p kinase phosphorylates SR proteins and regulates their cellular localization in fission yeast

Zhaohua Tang, Amy Tsurumi, Sarah Alaei, Christopher Wilson, Cathleen Chiu, Jessica Oya, Benson Ngo

Biochem J (2007) 405 (1): 21–30.

https://doi.org/10.1042/BJ20061523

Published: 13 June 2007

... 16 3 2007 16 3 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 alternative splicing cellular localization green fluorescent protein (GFP)-fusion protein protein kinase protein phosphorylation serine/arginine-rich protein (SR protein) SR proteins...

View article titled, Dsk1p kinase phosphorylates SR proteins and regulates their cellular localization in fission yeast

Articles

Phosphorylation of the 12 S globulin cruciferin in wild-type and abi1 - 1 mutant Arabidopsis thaliana (thale cress) seeds

Lianglu Wan, Andrew R. S. Ross, Jingyi Yang, Dwayne D. Hegedus, Allison R. Kermode

Biochem J (2007) 404 (2): 247–256.

https://doi.org/10.1042/BJ20061569

Published: 14 May 2007

... kinase signalling during seed development [ 29 , 30], we also examined protein phosphorylation in the abi1 - 1 mutant, in which PP2C activity is significantly reduced. We found that cruciferin is hyperphosphorylated in this mutant and is, therefore, a probable target for the ABI1 protein phosphatase...

View article titled, Phosphorylation of the 12 S globulin cruciferin in wild-type and abi1 - 1 mutant Arabidopsis thaliana (thale cress) seeds

Articles

Recombinant human hyaluronan synthase 3 is phosphorylated in mammalian cells

Brian J. Goentzel, Paul H. Weigel, Robert A. Steinberg

Biochem J (2006) 396 (2): 347–354.

https://doi.org/10.1042/BJ20051782

Published: 15 May 2006

... described below (B. J. Goentzel, P. H. Weigel and R. A. Steinberg, unpublished work). cAMP hyaluronan synthase (HAS) protein kinase protein phosphorylation signalling HA (hyaluronan, hyaluronic acid) is a ubiquitous component of vertebrate extracellular and cell-associated matrices...

View article titled, Recombinant human hyaluronan synthase 3 is phosphorylated in mammalian cells

Articles

The N-terminal domain of the human eIF2β subunit and the CK2 phosphorylation sites are required for its function

Franc Llorens, Anna Duarri, Eduard Sarró, Nerea Roher, Maria Plana, Emilio Itarte

Biochem J (2006) 394 (1): 227–236.

https://doi.org/10.1042/BJ20050605

Published: 27 January 2006

... 8 9 2005 14 10 2005 14 10 2005 The Biochemical Society, London 2006 eukaryotic translation initiation factor 2 (eIF2) HeLa cells human eIF2β subunit protein interaction protein kinase CK2 protein phosphorylation Translation initiation in eukaryotes requires...

View article titled, The N-terminal domain of the human eIF2β subunit and the CK2 phosphorylation sites are required for its function

Includes: Supplementary data

Articles

Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migration

Mariarita Bianchi, Stefania De Lucchini, Oriano Marin, David L. Turner, Steven K. Hanks, Emma Villa-Moruzzi

Biochem J (2005) 391 (2): 359–370.

https://doi.org/10.1042/BJ20050282

Published: 10 October 2005

... 20 6 2005 24 6 2005 24 6 2005 The Biochemical Society, London 2005 cell adhesion cell migration focal adhesion kinase (FAK) glycogen synthase kinase 3 (GSK3) protein phosphatase protein phosphorylation FAK (focal adhesion kinase) is a non-receptor tyrosine kinase...

View article titled, Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migration

Articles

Plant ribulosamine/erythrulosamine 3-kinase, a putative protein-repair enzyme

Juliette FORTPIED, Rita GEMAYEL, Vincent STROOBANT, Emile van SCHAFTINGEN

Biochem J (2005) 388 (3): 795–802.

https://doi.org/10.1042/BJ20041976

Published: 07 June 2005

... of the present study was to check for the presence of such an enzyme in plants and characterize its function. Amadori products erythrose 4-phosphate protein phosphorylation protein repair ribose 5-phosphate ribulosamine/erythrulosamine 3-kinase FN3K (fructosamine 3-kinase) is a recently...

View article titled, Plant ribulosamine/erythrulosamine 3-kinase, a putative protein-repair enzyme

Articles

Role of protein–protein interactions in the regulation of pyruvate dehydrogenase kinase activity

Alina TUGANOVA, Kirill M. POPOV

Biochem J (2005) 387 (1): 147–153.

https://doi.org/10.1042/BJ20040805

Published: 22 March 2005

... The Biochemical Society, London 2005 carbohydrate metabolism lipoyl-bearing domain binding mitochondria oxidative decarboxylation of pyruvate protein phosphorylation pyruvate dehydrogenase kinase PDHK (pyruvate dehydrogenase kinase) is an important molecular switch that turns off the activity...

View article titled, Role of protein–protein interactions in the regulation of pyruvate dehydrogenase kinase activity

Articles

Phosphorylation of septin 3 on Ser-91 by cGMP-dependent protein kinase-I in nerve terminals

Jing XUE, Peter J. MILBURN, Bernadette T. HANNA, Mark E. GRAHAM, John A. P. ROSTAS, Phillip J. ROBINSON

Biochem J (2004) 381 (3): 753–760.

https://doi.org/10.1042/BJ20040455

Published: 27 July 2004

... is phosphorylated on Ser-91 in nerve terminals and its phosphorylation may contribute to the regulation of its subcellular localization in neurons. Protein phosphorylation was performed in the presence of [γ- 32 P]ATP for 5 min [ 27 , 29 ]. Phosphoproteins were detected by gel electrophoresis...

View article titled, Phosphorylation of septin 3 on Ser-91 by cGMP-dependent protein kinase-I in nerve terminals

Articles

Molecular mechanisms regulating protein kinase Czeta turnover and cellular transformation

J. Ann LE GOOD, David N. BRINDLEY

Biochem J (2004) 378 (1): 83–92.

https://doi.org/10.1042/bj20031194

Published: 15 February 2004

... the ERK pathway and induces serum-independent growth and cell trans- formation. Our study demonstrates that protein phosphorylation has a more subtle and dynamic role than just simply regulating enzyme activity. Lack of phosphorylation at Thr-560 (combined with Thr-410 phosphorylation) protected PKC...

View article titled, Molecular mechanisms regulating protein kinase Czeta turnover and cellular transformation

Articles

Protein phosphatase 1 binds to phospho-Ser-1394 of the macrophage-stimulating protein receptor

Massimo M. SANTORO, Giovanni GAUDINO, Emma VILLA-MORUZZI

Biochem J (2003) 376 (3): 587–594.

https://doi.org/10.1042/bj20030391

Published: 15 December 2003

... factor receptor. Key words: Akt/protein serine/threonine kinase B (PKB), macrophage-stimulating protein (MSP), protein phosphatase, protein phosphorylation, receptor tyrosine kinase, Ron. INTRODUCTION Receptor tyrosine kinases (RTKs) can be regulated by PTPs (protein tyrosine phosphatases [1]) in many...

View article titled, Protein phosphatase 1 binds to phospho-Ser-1394 of the macrophage-stimulating protein receptor

Articles

Eukaryotic translation-initiation factor eIF2β binds to protein kinase CK2: effects on CK2α activity

Franc LLORENS, Nerea ROHER, Francesc A. MIRÓ, Stefania SARNO, F. Xavier RUIZ, Flavio MEGGIO, Maria PLANA, Lorenzo A. PINNA, Emilio ITARTE

Biochem J (2003) 375 (3): 623–631.

https://doi.org/10.1042/bj20030915

Published: 01 November 2003

... The Biochemical Society, London ©2003 2003 eukaryotic translation-initiation factor 2 (eIF2) enzymic regulation protein kinase CK2 protein phosphorylation protein—protein interaction surface plasmon resonance Abbreviations used: CK2, protein kinase CK2 (also known as casein kinase 2 or II); Ct...

View article titled, Eukaryotic translation-initiation factor eIF2β binds to protein kinase CK2: effects on CK2α activity

Articles

Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA)

Stefania SARNO, Erika De MOLINER, Maria RUZZENE, Mario A. PAGANO, Roberto BATTISTUTTA, Jenny BAIN, Doriano FABBRO, Joseph SCHOEPFER, Matthew ELLIOTT, Pascal FURET, Flavio MEGGIO, Giuseppe ZANOTTI, Lorenzo A. PINNA

Biochem J (2003) 374 (3): 639–646.

https://doi.org/10.1042/bj20030674

Published: 15 September 2003

... role of CK2 in living cells and may pave the way for the develop- ment of drugs depending on CK2 activity. Key words: dual-specificity tyrosine-phosphorylated and -regu- lated kinase 1a (DYRK1a), protein kinase inhibitor, protein phosphorylation, 4,5,6,7-tetrabromobenzotriazole (TBB). INTRODUCTION CK2...

View article titled, Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA)

Articles

The specificities of protein kinase inhibitors: an update

Jenny BAIN, Hilary McLAUCHLAN, Matthew ELLIOTT, Philip COHEN

Biochem J (2003) 371 (1): 199–204.

https://doi.org/10.1042/bj20021535

Published: 01 April 2003

..., Dundee DD1 5EH, Scotland, U.K., and MRC Protein Phosphorylation Unit, School of Life Sciences, MSI/WTB Complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, U.K. We have previously examined the specificities of 28 commercially available compounds, reported to be relatively selective...

View article titled, The specificities of protein kinase inhibitors: an update

Articles

PrpE, a PPP protein phosphatase from Bacillus subtilis with unusual substrate specificity

Adam IWANICKI, Anna HERMAN-ANTOSIEWICZ, Marcin PIERECHOD, Simone J. SÉROR, Michał OBUCHOWSKI

Biochem J (2002) 366 (3): 929–936.

https://doi.org/10.1042/bj20011591

Published: 15 September 2002

... phosphatases as well as with symmetrical diadenosine tetraphosphatases related to ApaH (symmetrical Ap % A hydrolase) from Escherichia coli. INTRODUCTION Protein phosphorylation or dephosphorylation is a prominent mechanism for signal transmission found in all living organisms. For many years, the nature...

View article titled, PrpE, a PPP protein phosphatase from Bacillus subtilis with unusual substrate specificity

Articles

Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complex

Alina TUGANOVA, Igor BOULATNIKOV, Kirill M. POPOV

Biochem J (2002) 366 (1): 129–136.

https://doi.org/10.1042/bj20020301

Published: 15 August 2002

... complex. 1 To whom correspondence should be addressed (e-mail popovk@umkc.edu ). 21 2 2002 15 4 2002 29 4 2002 The Biochemical Society, London ©2002 2002 carbohydrate metabolism mitochondria oxidative decarboxylation of pyruvate protein phosphorylation protein...

View article titled, Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complex

Articles

Expression and regulation of the AMP-activated protein kinase–SNF1 (sucrose non-fermenting 1) kinase complexes in yeast and mammalian cells: studies using chimaeric catalytic subunits

Tyrone DANIEL, David CARLING

Biochem J (2002) 365 (3): 629–638.

https://doi.org/10.1042/bj20020124

Published: 01 August 2002

... domain that mediates interaction with the yeast SNF1 protein kinase complex. EMBO. J. 13, 5878 5886 # 2002 Biochemical Society glucose repression metabolic stress protein phosphorylation The Biochemical Society, London ©2002 2002 18 1 2002 16 4 2002 24 4 2002 1...

View article titled, Expression and regulation of the AMP-activated protein kinase–SNF1 (sucrose non-fermenting 1) kinase complexes in yeast and mammalian cells: studies using chimaeric catalytic subunits

Articles

Structure–function analysis of yeast piD261/Bud32, an atypical protein kinase essential for normal cell life

Sonia FACCHIN, Raffaele LOPREIATO, Silvia STOCCHETTO, Giorgio ARRIGONI, Luca CESARO, Oriano MARIN, Giovanna CARIGNANI, Lorenzo A. PINNA

Biochem J (2002) 364 (2): 457–463.

https://doi.org/10.1042/bj20011376

Published: 01 June 2002

...@civ.bio.unipd.it ). 27 9 2001 2 1 2002 19 3 2002 The Biochemical Society, London ©2002 2002 casein CK2 protein phosphorylation Saccharomyces cerevisiae Ser/Thr kinase Abbreviations used: PKA, cAMP-dependent protein kinase; FSBA, fluorylsulphonylbenzoyladenosine...

View article titled, Structure–function analysis of yeast piD261/Bud32, an atypical protein kinase essential for normal cell life

Articles

Phosphorylation-dependent interaction of the synaptic vesicle proteins cysteine string protein and synaptotagmin I

Gareth J.O. EVANS, Alan MORGAN

Biochem J (2002) 364 (2): 343–347.

https://doi.org/10.1042/bj20020123

Published: 01 June 2002

... interaction might explain the Ca 2+ -dependent actions of CSP. 1 To whom correspondence should be addressed (e-mail gevans@liv.ac.uk ). 18 1 2000 20 3 2002 4 4 2002 The Biochemical Society, London ©2002 2002 exocytosis Hsc70 protein kinase A protein phosphorylation...

View article titled, Phosphorylation-dependent interaction of the synaptic vesicle proteins cysteine string protein and synaptotagmin I

Articles

Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells

Maria RUZZENE, Daniele PENZO, Lorenzo A. PINNA

Biochem J (2002) 364 (1): 41–47.

https://doi.org/10.1042/bj3640041

Published: 08 May 2002

... to caspase cleavage. casein kinase 2 cell death protein phosphorylation proteolysis Abbreviations used: HS1, haematopoietic lineage cell-specific protein 1; MTT, 3-(4,5-dimethylthiazol-2-yl)-3,5-diphenyltetrazolium bromide; PARP, poly(ADP-ribose) polymerase; TBB, 4,5,6,7...

View article titled, Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells

Articles

Tight-junction protein zonula occludens 2 is a target of phosphorylation by protein kinase C

Antonia AVILA-FLORES, Erika RENDÓN-HUERTA, Jacqueline MORENO, Socorro ISLAS, Abigail BETANZOS, Martha ROBLES-FLORES, Lorenza GONZÁLEZ-MARISCAL

Biochem J (2001) 360 (2): 295–304.

https://doi.org/10.1042/bj3600295

Published: 26 November 2001

... ). 14 2 2001 30 7 2001 26 9 2001 The Biochemical Society, London ©2001 2001 membrane-associated guanylate kinase MDCK cells protein kinase A protein phosphorylation Abbreviations used: GK, guanylate kinase; GST, glutathione S-transferase; LC, low Ca 2+ (1–5 μ M...

View article titled, Tight-junction protein zonula occludens 2 is a target of phosphorylation by protein kinase C

Articles

Cell-cycle-dependent association of protein phosphatase 1 and focal adhesion kinase

Marco FRESU, Mariarita BIANCHI, J. Thomas PARSONS, Emma VILLA-MORUZZI

Biochem J (2001) 358 (2): 407–414.

https://doi.org/10.1042/bj3580407

Published: 24 August 2001

... ©2001 2001 adhesion-associated protein tyrosine kinase cell adhesion mitosis protein phosphorylation serine/threonine phosphatase type 1 Abbreviations used: cdc2, cell division control kinase-2; DMEM, Dulbecco's modified Eagle's medium; FA, focal adhesion; FAK, focal adhesion...

View article titled, Cell-cycle-dependent association of protein phosphatase 1 and focal adhesion kinase

Articles

Assembly of protein kinase CK2: investigation of complex formation between catalytic and regulatory subunits using a zinc-finger-deficient mutant of CK2β

David A. CANTON, Cunjie ZHANG, David W. LITCHFIELD

Biochem J (2001) 358 (1): 87–94.

https://doi.org/10.1042/bj3580087

Published: 08 August 2001

... subunits into CK2 complexes. 1 To whom correspondence should be addressed (e-mail litchfi@julian.uwo.ca ). 2 1 2001 12 4 2001 23 5 2001 The Biochemical Society, London ©2001 2001 protein phosphorylation signal transduction mutagenesis Abbreviations used: CK2...

View article titled, Assembly of protein kinase CK2: investigation of complex formation between catalytic and regulatory subunits using a zinc-finger-deficient mutant of CK2β

Articles

Possible mechanisms involved in the down-regulation of translation during transient global ischaemia in the rat brain

Cristina MARTÍN de la VEGA, Jozef BURDA, Miroslava NEMETHOVA, Celia QUEVEDO, Alberto ALCÁZAR, M. Elena MARTÍN, Viera DANIELISOVA, Juan L. FANDO, Matilde SALINAS

Biochem J (2001) 357 (3): 819–826.

https://doi.org/10.1042/bj3570819

Published: 25 July 2001

... in the translational inhibition induced at early reperfusion, whereas eIF4F complex formation is likely to contribute to the persistent inhibition of translation observed at longer reperfusion times. Key words: cerebral ischaemia, initiation factors, ribosomal protein S6 kinase, protein phosphorylation, protein...

View article titled, Possible mechanisms involved in the down-regulation of translation during transient global ischaemia in the rat brain

Articles

The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bɛ at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase

Yvonne L. WOODS, Philip COHEN, Walter BECKER, Ross JAKES, Michel GOEDERT, Xuemin WANG, Christopher G. PROUD

Biochem J (2001) 355 (3): 609–615.

https://doi.org/10.1042/bj3550609

Published: 24 April 2001

... Downs syndrome insulin action protein phosphorylation signal transduction Biochem. J. (2001) 355, 609 615 (Printed in Great Britain) 609 The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Be at Ser539 and the microtubule-associated protein tau at Thr212 : potential role...

View article titled, The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bɛ at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase

Articles

Telomerase is regulated by protein kinase C-ζ in human nasopharyngeal cancer cells

Cheng-Chou YU, Shi-Ching LO, Tzu-Chien V. WANG

Biochem J (2001) 355 (2): 459–464.

https://doi.org/10.1042/bj3550459

Published: 06 April 2001

..., protein phosphorylation. Little is known concerning how telomerase activity is regulated in human cells. The promoter region of the hTERT gene has been characterized [21 23]. Sequence analysis has revealed that the hTERT promoter contains hormone-response elements and binding sites for several...

View article titled, Telomerase is regulated by protein kinase C-ζ in human nasopharyngeal cancer cells

Articles

Activity of hepatocyte nuclear factor 1α and hepatocyte nuclear factor 1β isoforms is differently affected by the inhibition of protein phosphatases 1/2A

Véronique CARRIÈRE, Michel LACASA, Monique ROUSSET

Biochem J (2001) 354 (2): 301–308.

https://doi.org/10.1042/bj3540301

Published: 22 February 2001

... 2001 Caco-2 clone TC7 DNA binding okadaic acid protein phosphorylation sucraseisomaltase Biochem. J. (2001) 354, 301 308 (Printed in Great Britain) 301 Activity of hepatocyte nuclear factor 1a and hepatocyte nuclear factor 1b isoforms is differently affected by the inhibition of protein...

View article titled, Activity of hepatocyte nuclear factor 1α and hepatocyte nuclear factor 1β isoforms is differently affected by the inhibition of protein phosphatases 1/2A

Articles

Identification of a novel isoform of the cyclic-nucleotide phosphodiesterase PDE3A expressed in vascular smooth-muscle myocytes

Young-Hun CHOI, Dag EKHOLM, Judith KRALL, Faiyaz AHMAD, Eva DEGERMAN, Vincent C. MANGANIELLO, Matthew A. MOVSESIAN

Biochem J (2001) 353 (1): 41–50.

https://doi.org/10.1042/bj3530041

Published: 18 December 2000

... 17 10 2000 The Biochemical Society, London © 2001 2001 intracellular signalling protein phosphorylation second messengers vasodilation Biochem. J. (2001) 353, 41 50 (Printed in Great Britain) 41 Identification of a novel isoform of the cyclic-nucleotide phosphodiesterase PDE3A...

View article titled, Identification of a novel isoform of the cyclic-nucleotide phosphodiesterase PDE3A expressed in vascular smooth-muscle myocytes

Articles

CREB (cAMP response element binding protein) and C/EBPα (CCAAT/enhancer binding protein) are required for the superstimulation of phosphoenolpyruvate carboxykinase gene transcription by adenoviral E1a and cAMP

John M. ROUTES, Lillester A. COLTON, Sharon RYAN, Dwight J. KLEMM

Biochem J (2000) 352 (2): 335–342.

https://doi.org/10.1042/bj3520335

Published: 24 November 2000

... of C/EBPα. 1 To whom correspondence should be addressed, at National Jewish Medical and Research Center (e-mail klemmd@njc.org ). 26 4 2000 21 8 2000 21 9 2000 The Biochemical Society, London © 2000 2000 adenovirus protein phosphorylation transcriptional synergy...

View article titled, CREB (cAMP response element binding protein) and C/EBPα (CCAAT/enhancer binding protein) are required for the superstimulation of phosphoenolpyruvate carboxykinase gene transcription by adenoviral E1a and cAMP

Articles

Bovine prion protein as a modulator of protein kinase CK2

Flavio MEGGIO, Alessandro NEGRO, Stefania SARNO, Maria RUZZENE, Alessandro BERTOLI, M. Catia SORGATO, Lorenzo A. PINNA

Biochem J (2000) 352 (1): 191–196.

https://doi.org/10.1042/bj3520191

Published: 07 November 2000

... words: casein kinase 2, enzymic regulation, protein phosphorylation, surface plasmon resonance, transmissible spongiform encephalopathies. latory role exploited by bPrP on CK2. We show here that bPrP interacts tightly with the catalytic subunits of CK2 and up- regulates their activity. EXPERIMENTAL...

View article titled, Bovine prion protein as a modulator of protein kinase CK2

Articles

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

Walter KOLCH

Biochem J (2000) 351 (2): 289–305.

https://doi.org/10.1042/bj3510289

Published: 10 October 2000

... e-mail wkolch@beatson.gla.ac.uk The Biochemical Society, London © 2000 2000 MAPK pathways multiprotein complexes protein phosphorylation scaffolding proteins signalling complexes signal transduction Biochem. J. (2000) 351, 289 305 (Printed in Great Britain) 289 REVIEW ARTICLE...

View article titled, Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

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