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Keywords: protein phosphatase
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Articles
Biochem J (2019) 476 (16): 2347–2350.
Published: 28 August 2019
... of a new tomato ( Solanum lycopersicum ) protein phosphatase that negatively controls early defence signalling. The phosphatase, termed pattern-triggered immunity inhibiting PP2C 1 (Pic1), negatively controls the signalling function of Pti1b and therefore holds a central position in the defence signalling...
Articles
Biochem J (2013) 456 (1): 109–118.
Published: 24 October 2013
... inhibitor Rottlerin or by siRNA knockdown significantly reduced TGF-β1-induced CTGF production. The regulatory mechanism was further demonstrated in HepG2 cells whereby TGF-β1-induced PKCδ activation negatively regulated the nuclear levels of PPM1A (protein phosphatase, Mg 2+ /Mn 2+ dependent, 1A) through...
Includes: Supplementary data
Articles
Biochem J (2013) 451 (1): 45–53.
Published: 14 March 2013
... enzymatic activities has been described which can dephosphorylate nuclear receptors. In the present study we used immunoprecipitation assays coupled to tandem MS analysis to identify novel PPARγ-regulating proteins. We identified the serine/threonine phosphatase PPM1B [PP (protein phosphatase), Mg 2+ /Mn 2...
Includes: Supplementary data
Articles
Biochem J (2012) 444 (3): 457–464.
Published: 29 May 2012
... phosphatase activity of PTEN, through which it dephosphorylates the 3 position in the inositol sugar of phosphatidylinositol derivatives, is important for its tumour suppressor function; however, the significance of its protein phosphatase activity remains unclear. Using two-photon laser-scanning microscopy...
Articles
Biochem J (2012) 442 (2): 357–368.
Published: 13 February 2012
...J. Albert Abrie; Asier González; Erick Strauss; Joaquín Ariño The Saccharomyces cerevisiae Hal3 protein is a moonlighting protein, able to function both as an inhibitory subunit of the Ppz1 protein phosphatase and as a constituent protomer of an unprecedented heterotrimeric PPCDC...
Includes: Supplementary data
Articles
Biochem J (2010) 430 (2): 191–198.
Published: 13 August 2010
... signalling and the essential role of protein phosphatases in this process. 1 To whom correspondence should be addressed (email xfeng@bcm.edu ). 23 3 2010 15 6 2010 17 6 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 dephosphorylation...
Articles
Biochem J (2009) 419 (2): 247–259.
Published: 27 March 2009
... The Authors Journal compilation © 2009 Biochemical Society 2009 metabolic regulation phosphorylation protein kinase protein phosphatase Snf1-related protein kinase (SnRK) stress signalling transcription factor The study of the enzymatic phosphorylation and dephosphorylation of proteins has...
Articles
Biochem J (2009) 418 (3): 475–489.
Published: 25 February 2009
...Kate I. Patterson; Tilman Brummer; Philippa M. O'brien; Roger J. Daly DUSPs (dual-specificity phosphatases) are a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. DUSPs have been...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2007) 407 (2): 255–266.
Published: 25 September 2007
... correspondence should be addressed (email i.h.batty@dundee.ac.uk ). 25 4 2007 1 8 2007 2 8 2007 2 8 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 lipid phosphatase phosphoinositide 3-kinase (PI3K) protein phosphatase reactive oxygen species...
Articles
Biochem J (2007) 406 (1): 13–18.
Published: 26 July 2007
... is the arrest of phagosome maturation, partly through interference with PtdIns signalling. The protein phosphatase MptpB is an essential secreted virulence factor in M. tuberculosis . A combination of bioinformatics analysis, enzyme kinetics and substrate-specificity characterization revealed that MptpB...
Articles
Biochem J (2006) 399 (3): 427–434.
Published: 13 October 2006
...-inflammatory kinase cascades. In the current study we report the crystal structure of the N-terminal domain of TAB1. Surprisingly, TAB1 possesses a fold closely related to that of the PPM (Mg 2+ - or Mn 2+ -dependent protein phosphatase) family as demonstrated by the close structural similarity with protein...
Articles
Biochem J (2006) 399 (2): 343–350.
Published: 27 September 2006
... mediate intracellular signalling events triggered by mitogens, growth factors and stress [ 7 ]. computer simulation enzyme mechanism hybrid potential phosphate ester protein phosphatase The inactivity of PTP active-site Cys→Ser mutants [ 9 , 19 ] is also not clearly understood. This mutation...
Articles
Biochem J (2006) 394 (1): 365–373.
Published: 27 January 2006
... of the Thr-Glu-Tyr motif of ERK8 was prevented by Ro 318220, a potent inhibitor of ERK8 in vitro . The catalytically inactive mutants ERK8[D154A] and ERK8[K42A] were not phosphorylated in HEK-293 cells or E. coli , whether or not the cells had been incubated with protein phosphatase inhibitors or exposed...
Articles
Biochem J (2005) 391 (2): 359–370.
Published: 10 October 2005
... by findings that both alanine substitution for S1 and dephosphorylation of S1 by PP1 (serine/threonine protein phosphatase type-1) resulted in an increase in FAK kinase activity; likewise, this role was also shown by cell treatment with the GSK3 inhibitor LiCl. The inhibitory role was confirmed by the finding...
Articles
Biochem J (2005) 385 (3): 685–693.
Published: 24 January 2005
... understood. Few direct targets for the diverse cellular effects of ceramide have been identified. Amongst those proposed is PP-1c, the catalytic subunit of serine/threonine PP-1 (protein phosphatase-1). Here, we present the first evidence of PP-1c activation by ceramide in live cells, namely NGF-deprived...
Articles
Biochem J (2004) 378 (1): 1–16.
Published: 15 February 2004
... by autophosphorylation at multiple sites, which can generate an autonomously active form of the kinase (Thr 286 ) or can block Ca 2+ /calmodulin binding (Thr 305/306 ). The regulated actions of protein phosphatases at these sites also modulate downstream signalling from CaMKII. In addition, CaMKII targeting to specific...
Articles
Biochem J (2003) 376 (3): 587–594.
Published: 15 December 2003
... in vitro by PP1 (protein phosphatase 1). PP1 associates with Ron obtained from cells of different origins. The association is stimulated by MSP or serum and is prevented by wortmannin, an inhibitor of the Akt/PKB (protein serine/threonine kinase B) pathway. Akt/PKB phosphorylates Ron Ser-1394, thus...
Articles
Biochem J (2003) 372 (1): 193–201.
Published: 15 May 2003
... protein phosphatase Abbreviations used: BMK1, big MAPK1; DTT, 1,4-dithiothreitol; ERK, extracellular-signal-regulated kinase; EGF, epidermal growth factor; GST, glutathione S-transferase; HA, haemagglutinin; HePTP, haemopoietic PTP; JNK, c-Jun N-terminal kinase; KIM, kinase-interaction motif; KIS...
Articles
Biochem J (2003) 371 (2): 621–629.
Published: 15 April 2003
... is inhibited by tautomycin and phosphatidic acid (PA), known inhibitors of protein phosphatase 1 (PP1), and by the PP2 inhibitor okadaic acid. The present study demonstrates one possible connected pathway for DHA action. By this pathway, low doses of DHA increase ceramide levels, which leads to inhibition...
Articles
Biochem J (2002) 368 (3): 789–797.
Published: 15 December 2002
...Louise PARKER; Sascha GROSS; Monique BEULLENS; Mathieu BOLLEN; Daimark BENNETT; Luke ALPHEY The catalytic subunit of type 1 Ser/Thr protein phosphatases (PP1c) forms complexes with many proteins that target it to particular subcellular locations and regulate its activity towards specific substrates...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2002) 368 (1): 349–355.
Published: 15 November 2002
... 2002 down-regulation dephosphorylation proteasome protein phosphatase Abbreviations used: BIM-I, bisindolylmaleimide I; FCS, foetal calf serum; GFP, green fluorescent protein; HA, haemagglutinin; MEF, mouse embryonic fibroblast; PKC, protein kinase C; PP1, protein phosphatase 1; PP2A...
Articles
Biochem J (2000) 347 (3): 845–855.
Published: 25 April 2000
...C. James HASTIE; Graeme K. CARNEGIE; Nick MORRICE; Patricia T. W. COHEN Protein phosphatase 4 (PPP4) is a protein serine/threonine phosphatase that has been implicated in microtubule organization at centrosomes. Complexes of PPP4 with high apparent molecular masses (450 and 600 kDa) were purified...
Articles
Biochem J (1999) 342 (2): 337–344.
Published: 24 August 1999
..., (conventional) protein kinase C; PKMa, PKCa catalytic domain fragment ; PP2A, protein phosphatase 2A; T(P)497, antiserum selective for phosphorylated Thr497 [T(P)638 and S(P)657 are similarly defined]. 1 Present address : Synthelabo Recherche (LERS), 31 avenue Paul Vaillant-Couturier, 9220 Bagneux, France. 2...
Articles
Biochem J (1999) 340 (1): 41–50.
Published: 10 May 1999
... of intracellular serine/threonine protein phosphatases, inhibited the α 3 β 1 -mediated adhesion of PC-3 cells to collagen IV and the α 2 β 1 -mediated attachment of Jurkat cells to collagen I. This inhibition by okadaic acid was accompanied by inhibition of the ligand-specific interaction of calreticulin...
Articles
Biochem J (1999) 339 (2): 241–246.
Published: 08 April 1999
... 8 2 1999 The Biochemical Society, London © 1999 1999 protein dephosphorylation protein phosphatase protein phosphorylation post-translational modification Biochem. J. (1999) 339, 241 246 (Printed in Great Britain) 241 Methylated C-terminal leucine residue of PP2A catalytic...