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Keywords: protein misfolding
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Biochem J (2020) 477 (16): 3033–3054.
Published: 26 August 2020
... system; mtDNA, mitochondrial DNA; OM, outer membrane; OXPHOS, oxidative phosphorylation; SAM, sorting and assembly machinery; TIM, translocase of the inner membrane; TOM, translocase of the outer membrane. mitochondrial dysfunction oxidative stress protein import protein misfolding...
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Biochem J (2019) 476 (23): 3549–3564.
Published: 03 December 2019
...). heat shock molecular chaperones protein misfolding protein quality control serine proteases β-barrel outer membrane proteins Bacterial cells often face a wide array of environmental stresses, including UV irradiation, heat shock, low pH, oxidative stress, and osmotic shock, which may...
Includes: Supplementary data
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Biochem J (2017) 474 (1): 123–147.
Published: 22 December 2016
...@chemistry.iitd.ac.in ) or Bishwajit Kundu ( bkundu@bioschool.iitd.ac.in ) 6 8 2016 25 10 2016 31 10 2016 1 11 2016 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 amyloid bispidine cytotoxicity oligomer prion protein misfolding...
Includes: Supplementary data
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Biochem J (2014) 464 (1): 85–98.
Published: 23 October 2014
... formation of toxic Aβ-species as well as the self-templating activity of Aβ fibrils, properties that could have therapeutic utility. Alzheimer’s disease amyloid Aβ42 (amyloid-β 42) Aβ43 (amyloid-β 43) foldamer protein misfolding Protein misfolding can be fatal [ 1 , 2 ]. Proteins misfold...
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Biochem J (2013) 456 (2): 173–184.
Published: 08 November 2013
... by protein misfolding if the proteasome is down-regulated as recently reported in humans with Type 2 diabetes. It remains unknown, however, whether the glucose sensor enzyme glucokinase is involved in this process. A direct interaction between glucokinase and ubiquitin could be shown in vivo by FRET...
Includes: Supplementary data
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Biochem J (2012) 447 (2): 185–192.
Published: 26 September 2012
... Biochemical Society 2012 BRICHOS domain HET-S prion hydrophobin melanin synthesis proinsulin C-peptide protein misfolding self-chaperoning spider silk For every polypeptide chain, a specific conformation or ensemble of conformations exists that represents its native fold. Yet, many...
Includes: Multimedia, Supplementary data
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Biochem J (2011) 439 (1): 67–77.
Published: 14 September 2011
... ganglioside membrane bilayer protein misfolding surface plasmon field-enhanced fluorescence spectroscopy Aβ peptides require treatment to ensure disaggregation and removal of preaggregated species [ 11 ], Solvents including HFIP, DMSO and TFE (trifluroethanol) have been shown to significantly...
Includes: Supplementary data
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Biochem J (2010) 430 (3): 477–486.
Published: 27 August 2010
... protein misfolding Prion diseases are invariably fatal neurodegenerative disorders of humans and animals that arise because of misfolding of the PrP C [cellular isoform of PrP (prion protein)], a GPI (glycosylphosphatidylinositol)-anchored glycoprotein whose function is not clear [ 1 ]. Unique...
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Biochem J (2007) 406 (2): e1.
Published: 13 August 2007
... Society 2007 cellular chaperone conformational disease cystic fibrosis cystic fibrosis transmembrane conductance regulator (CFTR) endoplasmic-reticulum-associated degradation (ERAD) protein folding protein misfolding pharmacological chaperone Biological organisms provide a unique...
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