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Keywords: protein kinases
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Biochem J (2022) 479 (18): 1917–1940.
Published: 23 September 2022
...Jeremy Thorner As first demonstrated in budding yeast ( Saccharomyces cerevisiae ), all eukaryotic cells contain two, distinct multi-component protein kinase complexes that each harbor the TOR (Target Of Rapamycin) polypeptide as the catalytic subunit. These ensembles, dubbed TORC1 and TORC2...
Includes: Supplementary data
Biochem J (2016) 473 (23): 4311–4325.
Published: 25 November 2016
... and the food industry. Prior genetic screens for Saccharomyces cerevisiae mutants with increased sensitivity to acetic acid identified loss-of-function mutations in the YPK1 gene, which encodes a protein kinase activated by the target of rapamycin (TOR) complex 2 (TORC2). We show in the present study...
Biochem J (2016) 473 (17): 2671–2685.
Published: 30 August 2016
...-synuclein-induced cytotoxicity in cellular and animal models of Parkinson's disease [ 22 , 23 ]. Finally, another protein kinase mutated in Parkinson's disease termed PINK1, indirectly controls the phosphorylation of a small group of Rabs including Rab8A at a site distinct from that used by LRRK2 (Ser 111...
Includes: Supplementary data
Biochem J (2016) 473 (2): 211–219.
Published: 05 January 2016
...); downstream, HDL inhibited the activation of p38 MAPK (mitogen-activated protein kinase) and the repression of the PI3K (phosphoinositide 3-kinase) pathway responsible for TF expression. In vivo , human apoA-I-transgenic mice displayed a reduced aortic TF expression compared with wild-type animals and TF...
Includes: Supplementary data
Biochem J (1999) 339 (1): 119–125.
Published: 25 March 1999
... protein kinases Biochem. J. (1999) 339, 119 125 (Printed in Great Britain) 119 Characterization of b2 (CD18) integrin phosphorylation in phorbol ester-activated T lymphocytes Leena VALMU*, Tiina J. HILDEN*, Gijsbert van WILLIGEN‹ and Carl G. GAHMBERG*1 *Department of Biosciences, Division...