...Jeremy Thorner As first demonstrated in budding yeast ( Saccharomyces cerevisiae ), all eukaryotic cells contain two, distinct multi-component protein kinase complexes that each harbor the TOR (Target Of Rapamycin) polypeptide as the catalytic subunit. These ensembles, dubbed TORC1 and TORC2...

... & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. BRAF cardiac hypertrophy cardiomyocytes inhibitors protein kinases Mammalian cardiomyocytes (the contractile cells of the heart) withdraw from the cell cycle in the perinatal period...

... and the food industry. Prior genetic screens for Saccharomyces cerevisiae mutants with increased sensitivity to acetic acid identified loss-of-function mutations in the YPK1 gene, which encodes a protein kinase activated by the target of rapamycin (TOR) complex 2 (TORC2). We show in the present study...

...-synuclein-induced cytotoxicity in cellular and animal models of Parkinson's disease [ 22 , 23 ]. Finally, another protein kinase mutated in Parkinson's disease termed PINK1, indirectly controls the phosphorylation of a small group of Rabs including Rab8A at a site distinct from that used by LRRK2 (Ser 111...

...); downstream, HDL inhibited the activation of p38 MAPK (mitogen-activated protein kinase) and the repression of the PI3K (phosphoinositide 3-kinase) pathway responsible for TF expression. In vivo , human apoA-I-transgenic mice displayed a reduced aortic TF expression compared with wild-type animals and TF...

...) is often used to indicate several classes of otherwise unrelated Ser}Thr protein kinases that share a preference for casein over histones, protamines and myelin basic protein as a phosphorylatable substrate in Šitro. This property, unusual among Ser}Thr kinases, reflects the ability of these enzymes...

... protein kinases Biochem. J. (1999) 339, 119 125 (Printed in Great Britain) 119 Characterization of b2 (CD18) integrin phosphorylation in phorbol ester-activated T lymphocytes Leena VALMU*, Tiina J. HILDEN*, Gijsbert van WILLIGEN‹ and Carl G. GAHMBERG*1 *Department of Biosciences, Division...