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Keywords: protein kinase C (PKC)
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Articles
Biochem J (2014) 457 (1): 151–162.
Published: 10 December 2013
... stress conditions. apoptosis calcineurin/nuclear factor of activated T-cells (NFAT) endoplasmic reticulum stress hypertrophy miRNA protein kinase C (PKC) Cardiac hypertrophy is a growth of the heart in response to an increased workload. Although hypertrophic growth appears...
Includes: Supplementary data
Articles
Biochem J (2013) 455 (1): 47–56.
Published: 13 September 2013
... protein 79 (AKAP79) muscarinic receptor phosphodiesterase 4 (PDE4) protein kinase A (PKA) protein kinase C (PKC) The muscarinic cholinergic receptor, a typical seven-transmembrane GPCR (G-protein-coupled receptor), binds the neurotransmitter acetylcholine and mediates numerous physiological...
Includes: Supplementary data
Articles
Biochem J (2013) 452 (2): 195–209.
Published: 10 May 2013
... 22 3 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 kinase activator kinase inhibitor kinase reporter phorbol ester protein kinase C (PKC) PKC (protein kinase C) isoenzymes transduce a wide range of extracellular signals that result in the generation...
Articles
Biochem J (2012) 448 (1): 165–169.
Published: 18 October 2012
... Biochemical Society 2012 B-cell antigen receptor (BCR) B-cell cell survival glycolysis metabolism protein kinase C (PKC) B-cell homoeostasis is critical for maintaining adaptive immunity and to avoid autoimmune and immunodeficiency diseases. In keeping with this, B-cells are dependent upon...
Includes: Supplementary data
Articles
Biochem J (2012) 447 (3): 393–405.
Published: 05 October 2012
... kinase C (PKC) muscarinic receptor somatostatin receptor cAMP (cyclic AMP) impacts on many aspects of the lives of eukaryotic cells to regulate numerous fundamental physiological functions [ 1 , 2 ]. The precise control of cAMP synthesis and subsequent physiological processes occur in a cell...
Includes: Supplementary data
Articles
Biochem J (2012) 447 (2): 193–204.
Published: 26 September 2012
... The Authors Journal compilation © 2012 Biochemical Society 2012 apoptosis cytoprotection endothelium inflammation protein kinase C (PKC) The vascular endothelium lies at a critical tissue interface and is capable of mounting specific responses to a variety of soluble and physical factors...
Includes: Supplementary data
Articles
Biochem J (2011) 439 (2): 287–297.
Published: 28 September 2011
... Society 2011 cancer mammalian target of rapamycin (mTOR) nucleotide pocket protein kinase B (PKB) protein kinase C (PKC) Sin1 Over recent years, the TOR (target of rapamycin) pathway has emerged as one of the key regulators of cell growth, providing a nexus for the integration of growth...
Includes: Supplementary data
Articles
Biochem J (2011) 436 (2): 469–480.
Published: 13 May 2011
... © The Authors Journal compilation © 2011 Biochemical Society 2011 ADP desensitization P2Y 12 receptor platelet protease-activated receptor (PAR) protein kinase C (PKC) Human platelets express the two PAR (protease-activated receptor) subtypes 1 and 4 [ 1 ]. Thrombin, the main...
Includes: Supplementary data
Articles
Biochem J (2011) 433 (1): 145–153.
Published: 15 December 2010
... 27 9 2010 13 10 2010 13 10 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 activator protein 1 (AP-1) breast cancer cell migration JunB protein kinase C (PKC) TBX3 transcription factor TBX3, a member of the developmentally important T-box...
Articles
Biochem J (2010) 432 (1): 153–163.
Published: 25 October 2010
.../licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. cytokine lymphocyte protein kinase C (PKC) protein kinase D (PKD) T-cell antigen receptor (TCR) The mammalian serine/threonine...
Articles
Biochem J (2010) 432 (1): 77–87.
Published: 25 October 2010
...-associated mutation F-box WD40 protein 7 (Fbw7) isoform-specific regulation nuclear localization protein kinase C (PKC) Fbw7 (F-box WD40 protein 7) is a conserved F-box WD40 protein, also known as Fbw6 in mice [ 1 ], archipelago in flies [ 2 ], SEL10 in worms [ 3 ] and Cdc4 in yeast [ 4 ]. Fbw7...
Articles
Biochem J (2010) 432 (1): 207–219.
Published: 25 October 2010
... kinase C (PKC) receptor for activated C-kinase 1 (RACK1) cAMP is a ubiquitous second messenger that controls pleiotropic cellular actions through the direct activation of its effectors, PKA (proteins kinase A) and EPAC (exchange protein activated by cAMP) [ 1 , 2 ]. cAMP PDEs (phosphodiesterases...
Includes: Supplementary data
Articles
Biochem J (2010) 429 (3): 565–572.
Published: 14 July 2010
..., provided the original work is properly cited. angiogenesis CRT5 inhibitor endothelium protein kinase C (PKC) protein kinase D (PKD) vascular endothelial growth factor (VEGF) PKDs (Protein kinase Ds) are DAG (diacylglycerol)-stimulated serine/threonine protein kinases, originally...
Articles
Biochem J (2010) 429 (2): 335–345.
Published: 28 June 2010
... synthase hypoxia mitochondrion oxidative phosphorylation protein kinase C (PKC) In the mammalian heart, the F 1 F o -ATP synthase supplies over 90% of the required energy and exists as a 16-subunit enzyme complex in the IMM (inner mitochondrial membrane). It has an F 1 domain (3α, 3β, γ, δ...
Articles
Biochem J (2010) 427 (1): 125–134.
Published: 15 March 2010
... junctional membrane complex junctophilin 2 muscle hypertrophy protein kinase C (PKC) transient receptor potential cation canonical-type channel 3 (TRPC3) During EC (excitation–contraction) coupling in striated muscle (cardiac and skeletal muscle), the DHPR (dihydropyridine receptor) Ca 2...
Articles
Biochem J (2010) 425 (2): 445–543.
Published: 23 December 2009
... mukinase@kobe-u.ac.jp ). 5 3 2009 28 9 2009 26 10 2009 26 10 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 cell-penetrating peptide (CPP) penetration accelerating sequence octa-arginine (LPasR8) PRL protein kinase C (PKC) PKN inhibitor...
Includes: Supplementary data
Articles
Biochem J (2009) 417 (3): 791–801.
Published: 16 January 2009
... palmitate protein kinase B (PKB) protein kinase C (PKC) Hyperlipidaemia is one of a cluster of abnormalities associated with the metabolic syndrome and one that is considered important for both development and progression of insulin resistance in skeletal muscle, a tissue that makes a major...
Includes: Supplementary data
Articles
Biochem J (2009) 417 (3): 705–715.
Published: 16 January 2009
... ). 16 6 2008 12 9 2008 16 9 2008 16 9 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 cross-talk extracellular-signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) phosphorylation potassium channel protein kinase C (PKC...
Articles
Biochem J (2008) 416 (1): 47–54.
Published: 28 October 2008
... truncated at residue 149 (Cp149) Ser 106 hepatitis B virus (HBV) protein kinase C (PKC) phosphorylation The number of human HBV (hepatitis B virus) patients exceeds over 400 million people worldwide, causing acute and chronic B type hepatitis in these patients. It has been reported that chronic...
Includes: Supplementary data
Articles
Biochem J (2008) 416 (1): 99–108.
Published: 28 October 2008
... transporter 1 (PAT1) phosphoinositide 3-kinase (PI3K) protein kinase C (PKC) ROS (reactive oxygen species), including H 2 O 2 , O 2 − (superoxide anion), OH − (hydroxyl anion) and HOCl (hypochlorite), are generated in tissues as a consequence of normal cellular aerobic metabolism. These oxidants...
Articles
Biochem J (2008) 415 (1): 77–85.
Published: 12 September 2008
...-regulated kinase 1/2) signalling [ 7 ]. Thus dissecting mTOR-independent pathways is of major importance in order to fully grasp the complexity of translational regulation. eukaryotic initiation factor 6 (eIF6) hispidin phorbol ester protein kinase C (PKC) receptor for activated C-kinase 1...
Includes: Supplementary data
Articles
Biochem J (2008) 411 (3): 543–551.
Published: 14 April 2008
... 1 2 2008 1 2 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 gastric muscle muscle contraction myosin light chain nuclear factor κB (NF-κB) signalling protein kinase C (PKC) The bioactive lipids LPA (lysophosphatidic acid) and S1P (sphingosine 1...
Articles
Biochem J (2008) 411 (2): e15–e16.
Published: 27 March 2008
... activity in situ . 1 email Christer.Larsson@med.lu.se 15 2 2008 18 2 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 enzyme regulation 14-3-3 protein phosphorylation protein kinase C (PKC) Protein kinase C (PKC) was first identified some 30...
Articles
Biochem J (2007) 408 (1): 51–59.
Published: 29 October 2007
... © The Authors Journal compilation © 2007 Biochemical Society 2007 cell proliferation membrane protein myristoylated alanine-rich C-kinase substrate (MARCKS) neural retina protein kinase C (PKC) proteomics The mature neural retina is organized into a three-layered structure...
Articles
Biochem J (2007) 406 (3): 501–509.
Published: 29 August 2007
... compilation © 2007 Biochemical Society 2007 phospholipase C (PLC) phosphorylation protease-activated receptor (PAR) protein kinase C (PKC) Src family kinase (SFK) thrombin The PKC (protein kinase C) family is composed of ten isoenzymes, which are grouped into three classes: conventional (α...
Articles
Biochem J (2007) 405 (3): 533–540.
Published: 13 July 2007
... phosphorylation protein kinase C (PKC) Woronin body Filamentous ascomycete and deuteromycete fungi possess the ‘Woronin body’, a unique organelle that seals the septal pore in the event of hyphal damage [ 1 ]. Septal pore plugging by this dense proteinaceous organelle prevents hyphal bleeding...
Articles
Biochem J (2007) 404 (1): 31–43.
Published: 26 April 2007
... calmodulin neurogranin phosphatidic acid phosphatidylinositol 4,5-bisphosphate phospholipase D (PLD) protein kinase C (PKC) Neurogranin (Ng) (also named RC3, p17 or BICK) is a small protein originally identified in rat brain [ 1 – 3 ] that is abundantly expressed in the cerebral cortex...
Articles
Biochem J (2007) 403 (1): 1–12.
Published: 13 March 2007
... kinase C (PKC) Rac GTPase-activating protein (RacGAP) The Ras superfamily of small GTPases or small G-proteins is composed of five major families that share similar sequences and biochemical properties: Ras, Rho, Rab, Ran and Arf [ 1 , 2 ]. More than 150 members in the Ras superfamily have been...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2006) 400 (3): 411–419.
Published: 28 November 2006
... The Biochemical Society, London 2006 arginine-vasopressin (AVP) cardiac L-type calcium channel G-protein L6 cell protein kinase C (PKC) The voltage-dependent Ca 2+ channels of the long-lasting, or L-type, play important roles in a variety of cellular functions, including for example...
Articles
Biochem J (2006) 399 (3): 493–501.
Published: 13 October 2006
... extracellular-signal-regulated kinase (ERK) pathway G-protein-coupled receptor (GPCR) protein kinase C (PKC) Raf Ras In cardiac myocytes, as in other cell types, numerous cellular processes are sensitive to changes in pH i (intracellular pH). In particular, almost every step in the excitation...
Articles
Biochem J (2006) 397 (1): 109–120.
Published: 14 June 2006
... signalling role(s) for the cellular complex characterize this interaction. fluorescence lifetime imaging microscopy (FLIM) fluorescence resonance energy transfer (FRET) protein complex protein kinase C (PKC) renal cell carcinoma (RCC) von Hippel–Lindau protein (pVHL) To determine...
Includes: Supplementary data
Articles
Biochem J (2006) 393 (2): 555–564.
Published: 23 December 2005
... kinase C (PKC) Rho kinase thrombin vasodilator-stimulated phosphoprotein (VASP) The multifunctional organizer of the actin cytoskeleton VASP (vasodilator-stimulated phosphoprotein), together with Drosophila Ena (Enabled), is the original member of the Ena/VASP family, which consists further...
Articles
Biochem J (2005) 392 (1): 163–172.
Published: 08 November 2005
... or Sigma–Aldrich. 11 7 2005 9 9 2005 9 9 2005 9 9 2005 The Biochemical Society, London 2005 cAMP cytoskeleton 14-3-3 protein phorbol ester phosphodiesterase 3A (PDE3A) protein kinase C (PKC) Cyclic nucleotide PDEs (phosphodiesterases) hydrolyse cAMP and cGMP...
Includes: Supplementary data
Articles
Biochem J (2004) 384 (3): 543–549.
Published: 07 December 2004
... kinase C (PKC) MnSOD (manganese superoxide dismutase) is an essential antioxidant enzyme that catalyses the conversion of superoxide radical into hydrogen peroxide and molecular oxygen within the mitochondrial matrix [ 1 ]. ROS (reactive oxygen species), including the superoxide radical...
Articles
Biochem J (2004) 384 (2): 349–355.
Published: 23 November 2004
..., University of Utrecht, The Netherlands (email R.R.Bosch@vet.uu.nl ). 13 5 2004 14 7 2004 13 8 2004 13 8 2004 The Biochemical Society, London 2004 glucose uptake myristoylated protein kinase Cβ peptide inhibitor phorbol ester protein kinase C (PKC) 3T3-L1 adipocyte...
Articles
Biochem J (2004) 382 (1): 101–110.
Published: 10 August 2004
... 2004 14 5 2004 G-protein-coupled receptor (GPCR) metabotropic glutamate receptor phosphorylation protein kinase C (PKC) P2X receptor P2Y receptor Extracellular ATP functions as a signalling molecule through the activation of P2X receptors [ 1 ]. Sources of ATP include co...
Articles
Biochem J (2004) 378 (1): 83–92.
Published: 15 February 2004
...J. Ann LE GOOD; David N. BRINDLEY The regulation of protein kinase C (PKC)ζ in relation to its turnover, cell growth and transformation was investigated in Rat2 fibroblasts by over-expressing wild-type or mutant forms of PKCζ. Deletion of the pseudosubstrate site (PSS) produced the most active...
Articles
Biochem J (2003) 376 (3): 667–676.
Published: 15 December 2003
... 3 R) phospholipase C (PLC) protein kinase C (PKC) Abbreviations used: 2-APB, 2-aminoethoxydiphenyl borate; BCR, B-cell receptor; BLNK, B -cell l i nk er; DAG, diacylglycerol; ER, endoplasmic reticulum; eYFP, enhanced yellow fluorescent protein; FBS, foetal bovine serum; fura-2/AM, fura...
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Biochem J (2003) 376 (3): 545–552.
Published: 15 December 2003
...Seng-Lai TAN; Peter J. PARKER Members of the protein kinase C (PKC) family are expressed in many different cell types, where they are known to regulate a wide variety of cellular processes that impact on cell growth and differentiation, cytoskeletal remodelling and gene expression in the response...
Articles
Biochem J (2003) 375 (2): 313–321.
Published: 15 October 2003
...: 2-chimaerin, diacylglycerol (DAG), phorbol ester, protein kinase C (PKC), Rac-GTPase-activating protein (Rac- GAP), Rho GTPase. INTRODUCTION The phorbol ester tumour promoters are the most widely used compounds for the activation of PKC (protein kinase C), a family of related serine/threonine...
Articles
Biochem J (2003) 374 (2): 537–543.
Published: 01 September 2003
... modified Eagle's medium; EM, electron microscopy; KLH, keyhole limpet haemocyanin; PKC, protein kinase C; pS, phosphoserine; RK, rhodopsin kinase; ROS, rod outer segment. phosphorylation phototransduction protein kinase C (PKC) rhodopsin rhodopsin kinase (RK) signal transduction Biochem. J...
Articles
Biochem J (2003) 371 (3): 733–742.
Published: 01 May 2003
...Carole GALLET; Stéphanie BLAIE; Sylviane LÉVY-TOLEDANO; Aïda HABIB The signalling pathways that link G-protein-coupled receptors to mitogen-activated protein kinases involve receptor and non-receptor tyrosine kinases and protein kinase C (PKC). We explored the pathways that are implicated...
Articles
Biochem J (2003) 370 (2): 361–371.
Published: 01 March 2003
... The Biochemical Society, London ©2003 2003 phosphoinositide 3-kinase phosphoinositide-dependent kinase-1 (PDK-1) phosphorylation motif protein kinase A (PKA) protein kinase B (PKB)/Akt protein kinase C (PKC) Abbreviations used: PDK-1, phosphoinositide-dependent kinase-1; PH, pleckstrin...
Articles
Biochem J (2002) 368 (3): 809–815.
Published: 15 December 2002
... myosin II heavy chain kinase (MHCK) phosphatidic acid protein kinase C (PKC) Abbreviations used: DG, 1,2-diacylglycerol; DGK, diacylglycerol kinase; MHC, myosin II heavy chain; MHCK, myosin II heavy chain kinase; MHC-PKC, myosin heavy chain-protein kinase C; PA, phosphatidic acid; PH...
Articles
Biochem J (1999) 342 (2): 407–414.
Published: 24 August 1999
... 5 1999 21 6 1999 The Biochemical Society, London © 1999 1999 angiotensin II cyclin platelet-derived growth factor (PDGF) protein kinase C (PKC) Biochem. J. (1999) 342, 407 414 (Printed in Great Britain) 407 Differential regulation of extracellular signal-regulated protein...