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Keywords: protein degradation
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Biochem J (2020) 477 (5): 905–923.
Published: 04 March 2020
... type domain protein degradation structure Ubiquitination is a vital post-translational modification that affects several key signaling events, including protein homeostasis, DNA damage, innate immunity, and neurodegenerative diseases [ 1 , 2 ]. Ubiquitination is brought about...
Includes: Supplementary data
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Biochem J (2020) 477 (2): 477–489.
Published: 31 January 2020
.... Analysis with mass spectrometry identified that BAG6 is one of the major proteins interacting with PAQR9 and such interaction is confirmed by co-immunoprecipitation and co-localization assays. The protein degradation rate of representative MLPs is accelerated by PAQR9 knockdown. Consistently...
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Biochem J (2017) 474 (22): 3719–3732.
Published: 01 November 2017
... by Portland Press Limited on behalf of the Biochemical Society 2017 angiogenesis mass spectrometry metalloproteases protein degradation syndecans Syndecans (SDCs), including SDC1–4, are transmembrane proteoglycans that contain glycosaminoglycan chains. SDCs participate in cell adhesion...
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Biochem J (2017) 474 (19): 3355–3371.
Published: 25 September 2017
..., further research is essential to determine how phosphorylation of different subunits by these (or other) kinases alters the properties of this complex molecular machine and thus influence protein degradation rates. Correspondence: Alfred Goldberg ( alfred_goldberg@hms.harvard.edu ) 22 6 2017...
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Biochem J (2017) 474 (10): 1653–1668.
Published: 04 May 2017
..., USP7, stabilized the HIV-1 Tat protein through its deubiquitination. Treatment with either a general DUB inhibitor (PR-619) or USP7-specific inhibitor (P5091) resulted in Tat protein degradation. The USP7-specific inhibitor reduced virus production in a latently infected T-lymphocytic cell line J1.1...
Includes: Supplementary data
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Biochem J (2015) 469 (3): 469–480.
Published: 23 July 2015
... regulator of PAQR3 and modulates tumorigenesis. cell proliferation DDB2 gastric cancer protein degradation tumour suppressor ubiquitination DDB2 (damage-specific DNA-binding protein 2) is the product of the XPE (xeroderma pigmentosum group E) gene and a defect in this gene causes...
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Biochem J (2015) 466 (3): 571–585.
Published: 06 March 2015
... degradation. connexin CIP75 ERAD proteasome protein degradation Gap junctions are cell-to-cell channels that allow for the direct exchange of ions and low molecular mass metabolites (<1 kDa) between adherent cells via gap junctional intercellular communication (GJIC) [ 1 ]. They provide...
Includes: Supplementary data
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Biochem J (2014) 458 (1): 57–67.
Published: 20 January 2014
... with the connexin43-interacting protein of 75 kDa at the endoplasmic reticulum membrane. connexin connexin43-interacting protein of 75 kDa (CIP75) endoplasmic reticulum-associated degradation (ERAD) proteasome protein degradation protein translocation One subset of the UDP (ubiquitin domain protein...
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Biochem J (2012) 444 (3): 581–590.
Published: 29 May 2012
... proliferation in breast cancer cells. In this loop ATBF1 inhibits the function of oestrogen–ERα signalling, whereas ATBF1 protein levels are fine-tuned by oestrogen-induced transcriptional up-regulation as well as UPP (ubiquitin–proteasome pathway)-mediated protein degradation. In the present study we show...
Includes: Supplementary data
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Biochem J (2012) 444 (1): 141–151.
Published: 26 April 2012
... in oncogenic signalling downstream of the PI3K (phosphoinositide 3-kinase) pathway [ 3 ] and is activated in many cancers. AZD8055 eukaryotic initiation factor (eIF) mammalian target of rapamycin (mTOR) mRNA translation protein degradation stable isotope-labelling with amino acids in cell culture...
Includes: Supplementary data
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Biochem J (2012) 443 (3): 681–689.
Published: 16 April 2012
...) Huntington's disease (HD) protein degradation toxicity ubiquitination A pseudopupil assay was performed as described previously [ 40 ]. The Drosophila adult eye is composed of approximately 800 ommatidia, and each ommatidium contains eight photoreceptor neurons. The pseudopupil assay is a method...
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Biochem J (2011) 435 (3): 641–649.
Published: 13 April 2011
... induction of the GAL1 gene and we have found that galactose-induced protein degradation of the repressor Mig2 is defective in this strain. Mig2 degradation was also abolished in cells lacking the protein kinase Snf1 and the F-box protein Das1, suggesting that Snf1 triggers galactose-induced protein...
Includes: Supplementary data
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Biochem J (2011) 435 (1): 1–16.
Published: 15 March 2011
... © 2011 Biochemical Society 2011 procoagulant protease therapy protein degradation protein engineering trypsin fold Sequencing of the human genome revealed that more than 2% of our genes encode proteases, suggesting that these enzymes possess functions more complex than the simple...
Includes: Supplementary data
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Biochem J (2011) 434 (2): 233–242.
Published: 11 February 2011
... activator receptor (u-PAR) glycolipid anchor protein degradation u-PAR (urokinase-type plasminogen activator receptor), a 45–60 kDa glycosylated receptor [ 1 ] composed of three similar repeats [ 2 ], is connected to the cell surface via a GPI (glycosylphosphatidylinositol, i.e. a glycolipid...
Includes: Supplementary data
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Biochem J (2010) 432 (1): 217–226.
Published: 25 October 2010
... © The Authors Journal compilation © 2010 Biochemical Society 2010 degron human thymidylate synthase (hTS) intrinsically disordered region proteasome protein degradation ubiquitin-independent The proteasome is a large multi-subunit complex of several dozen proteins...
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Biochem J (2010) 431 (3): 391–402.
Published: 11 October 2010
... activation. 1 To whom correspondence should be addressed (email micln@nus.edu.sg ). 28 7 2010 23 8 2010 26 8 2010 26 8 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 de-ubiquitination proteasome protein degradation regulation of gene...
Includes: Supplementary data
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Biochem J (2010) 429 (1): 127–136.
Published: 14 June 2010
... compilation © 2010 Biochemical Society 2010 LIM-domain-binding 1 (LDB1) post-translational modification proteasome protein degradation RING finger protein 12 (RNF12) ubiquitin ligase LDB1 (LIM-domain-binding 1) is a highly conserved transcription cofactor that was initially identified...
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Biochem J (2010) 426 (1): 13–17.
Published: 27 January 2010
... compilation © 2010 Biochemical Society 2010 half-life mitochondrion proteasome protein degradation uncoupling protein 1 (UCP1) uncoupling protein 3 (UCP3) The UCPs (uncoupling proteins) are a subset of the mitochondrial solute carrier family: transporters of metabolites, protons...
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Biochem J (2010) 425 (1): e1–e3.
Published: 14 December 2009
... autophagy Bag3 co-chaperone HspB6 HspB8 muscular dystrophy protein degradation Heat-shock proteins (Hsps), also called molecular chaperones, perform folding, stabilization, trafficking and degradation functions to maintain cellular homoeostasis. Mutation, overexpression or deletion of chaperones...
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Biochem J (2009) 422 (2): 207–215.
Published: 13 August 2009
... 2009 7 7 2009 7 7 2009 Protein degradation is an important mechanism involved in broad cellular events such as post-translational quality control, cell-cycle regulation and development [ 1 – 3 ]. In eukaryotes, the process of degradation is carried out by the ubiquitin–proteasome system...
Includes: Supplementary data
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Biochem J (2008) 414 (2): 221–229.
Published: 12 August 2008
... Society 2008 cancer mutation neural-precursor-cell-expressed developmentally down-regulated 4-1 (NEDD4-1) phosphatase and tensin homologue deleted on chromosome 10 (PTEN) protein degradation stability ubiquitination Figure 2 Total reconstitution of NEDD4-1-catalysed PTEN...
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Biochem J (2004) 382 (2): 695–702.
Published: 24 August 2004
... with that obtained in L-BEVS, suggesting that more tightly folded LUC was produced in N-BEVS. YLC expression was also analysed by Western blotting, revealing significantly less protein degradation in N-BEVS than in L-BEVS, in which extensive degradation was observed. This FRET-based in vivo folding technology showed...
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Biochem J (2004) 381 (3): 761–767.
Published: 27 July 2004
... and normalized to 60 S aRP-cDNA. The Biochemical Society, London 2004 hypoxia-inducible factor oxygen sensing post-translational modification prolyl hydroxylation protein degradation von-Hippel-Lindau protein The ability to adapt to acute and chronic hypoxia is crucial for survival...
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Biochem J (2004) 380 (1): 289–295.
Published: 15 May 2004
... hypoxia-inducible factor-1α (HIF-1α) p53 p300 protein degradation transcriptional regulation Abbreviations used: Epo, erythropoietin; HA, haemagglutinin; HIF-1, hypoxia-inducible factor-1; HRP, horseradish peroxidase; IVTT, in vitro transcription/translation; Mdm2, mouse double minute 2...
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Biochem J (2003) 373 (1): 201–210.
Published: 01 July 2003
... 3 2003 27 3 2003 The Biochemical Society, London ©2003 2003 apoptosis breast cancer cell caspase activation protein degradation Abbreviations used: Ad-LacZ, adenovirus expressing lacZ gene; FAK, focal adhesion kinase; FAK-NT, FAK N-terminus; Ad-FAK-NT, adenovirus...
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Biochem J (2003) 371 (3): 937–945.
Published: 01 May 2003
.... We report for the first time that SRp55 can be hyperphosphorylated under different circumstances whereby its fate is differentially influenced. Key words: nuclear speckles, protein degradation, serine/ arginine-rich (SR) protein kinase, transcription inhibitor. INTRODUCTION The removal of introns...
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Biochem J (2002) 364 (1): 275–284.
Published: 08 May 2002
... of whole mitochondria. Key words: autophagy, CoA modification, hepatocytes, protein degradation. ATP-dependent proteases, matrix or membrane localized, exist in mitochondria of eukaryotic cells. A Lon-like ATP-dependent protease that is highly homologous with bacterial Lon protease has been demonstrated...
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Biochem J (2001) 354 (1): 31–36.
Published: 08 February 2001
... is the initial step of bulk protein degradation in liver. Hepatic autophagosomes have a half-life of approx. 10 min [1]. The exact biochemical events responsible for the regulation of autophagosome formation are only poorly understood. In rat liver, autophagic proteolysis is under the control of insulin [1,2...
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Biochem J (2000) 346 (2): 509–518.
Published: 22 February 2000
..., London © 2000 2000 methotrexate resistance membrane protein N-glycosylation protein degradation Biochem. J. (2000) 346, 509 518 (Printed in Great Britain) 509 Mutations in the reduced-folate carrier affect protein localization and stability Heather SADLISH, Richard C. MURRAY, Frederick M. R...
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Biochem J (2000) 345 (1): 1–15.
Published: 17 December 1999
.... The Biochemical Society, London © 2000 2000 cellular immunity, 26S proteasome protein degradation ubiquitin-mediated proteolysis Biochem. J. (2000) 345, 1 15 (Printed in Great Britain) 1 REVIEW ARTICLE The proteasome activator 11 S REG (PA28) and Class I antigen presentation Martin RECHSTEINER1...
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Biochem J (1999) 343 (2): 425–433.
Published: 08 October 1999
...} vacuolar compartment of cells or secreted into the medium, which is consistent with the acidic pH optimum for activity [1,3]. They are believed to be involved in specific protein processing or general protein degradation in all systems analysed. The plant aspartic proteinases have been isolated from nu...
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