... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cellular targeting endoplasmic reticulum ERAD molecular chaperones protein conformation ubiquitin proteasome system One notable group of ion channels that associate with and co-regulate CFTR...

... of the Biochemical Society 2021 intrinsically disordered proteins protein conformation protein structure structure–function continuum Based on the Web of Science (as of the middle of July, 2021) data, there are almost 9500 papers dedicated to intrinsically disordered proteins (IDPs) that have...

... the Creative Commons Attribution License 4.0 (CC BY) . ARHL circular cross-correlation interaction networks protein conformation statistical and computational modeling tip-link proteins The origin of age-related hearing loss (ARHL) or presbycusis is multifactorial [ 1–4 ]. However...

... parasite survival in the human host. These findings open avenues for rational small-molecule based SAR for disruption of critical parasite chaperone interactions for antimalarial interventions. aggregation HSP malaria plasmodium protein conformation PfHSP70-1 (PF3D7_0818900), PfHSP40...

... to extricate, it should still be possible to relate the sequence patterns to the energetic outcomes and the eventual impact on folding and function. kinetic stability point mutations protein conformation sequence evolution statistical model thermodynamics The author declares...

... of University of Adelaide in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with CAUL. α-lactalubumin β-casein mass spectrometry molecular chaperones protein aggregation protein conformation Globular proteins rely...

... of the Biochemical Society 2019 crystallography GTPases hydrogen–deuterium exchange mass spectrometry leucine-rich repeat kinase protein conformation Roco proteins Roco proteins are a class of G proteins that occur in all three domains of life and are characterized by the presence of a Roc ( R...

... of the Biochemical Society 2018 cytoskeleton molecular chaperones protein conformation Correspondence: Keith Robert Willison ( keith.willison@imperial.ac.uk ) We have traced the emergence of chaperonins back to the last universal common ancestor of all organisms (LUCA). While refining the yeast...

... 6 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 binding IDP molecular interactions nuclear–protein protein conformation protein stability NUPR1 is an 82-residue-long (8 kDa), highly basic, monomeric IDP...

... 2 2018 1 3 2018 2 3 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 apoptosis CARD caspase-9 circular dichroism interdomain interactions protein conformation Apoptosis or programmed cell death...

... by superposition on the corresponding domains of σ 28 . The complete built closed model of σ S was then subjected to energy minimization with the NAMD2 program [ 31 ] using CHARMM27 force field. The system was minimized by 3000 steps of conjugate gradient minimization. protein conformation protein...

... the maximum. The midpoint of denaturation ( T m ) was determined from the optimum fit of an equation describing two-state unfolding [ 39 , 51 , 52 ]: allosteric regulation antibodies protein aggregation protein conformation protein–protein interactions serpin α 1 -Antitrypsin (α 1...

... different experiments. Alzheimer's disease amyloid BRICHOS molecular chaperone protein conformation protein inclusions In neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, amyloid formation is believed to be a main cause [ 1 – 3 ]. Although amyloid-forming...

... profiles at distinct dorsal spinal cord and dorsal root ganglion developmental stages. Ser 119 phosphorylation modulates PRRXL1 conformation and transcriptional activity. embryonic and fetal development nociception paired related homeobox-like 1 (PRRXL1) phosphorylation protein conformation...

... 10 2013 31 10 2013 31 10 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 The cytokine-induced phosphorylation of the NF-κB subunit p65 results in conformational changes of the protein. heat-shock protein p65 protein conformation nuclear factor...

... spontaneous detrimental effects in ovine PrP transgenic Drosophila . Drosophila prion disease prion protein (PrP) protein conformation transgenic Mammalian prion diseases are fatal neurodegenerative conditions of humans and various other vertebrate species. These diseases include scrapie...

... gm290@cam.ac.uk ). 3 2 2010 17 3 2010 29 3 2010 29 3 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 disulfide bond pattern metalloproteinase protein conformation protein disulfide isomerase (PDI) redox regulation shedding...

... by centrifugation at 2000  g for 2 min to remove insoluble protein aggregates. The protein concentration in the supernatant was measured by absorbance at 280 nm using a Nanodrop ND-1000 spectrophotometer (BioLab). disulfide bond prion prion protein protein conformation The prion diseases...

...-free buffer until used for kinetic analysis or spectrofluorimetry. allosteric activation equilibrium binding glucokinase activator drugs (GKA drugs) glucokinase disease (GK disease) glucokinase protein conformation tryptophan fluorescence A leading player in the regulation of blood...

..., a panel of four monoclonal antibodies was raised to the denatured protein and used as probes of protein conformation. The linear sequence epitope reactivity of a polyclonal antibody raised against the native protein and the monoclonal antibodies were defined and mapped to distinct regions on the IDS...

... translocase, atractyloside (ATR), mito- chondrial transport protein, protein conformation. INTRODUCTION The mitochondrial ADP/ATP translocase (AAT) catalyses the exchange, across the inner membrane of the organelle, of cytosolic ADP for ATP, produced in the matrix by ATP-synthase. The AAT is the most highly...

... The Biochemical Society, London © 2000 2000 actin binding phosphorylation protein conformation protein kinase C smooth muscle tropomyosin Biochem. J. (2000) 350, 579 588 (Printed in Great Britain) 579 A role for serine-175 in modulating the molecular conformation of calponin Jian-Ping JIN*1, Michael...

... (C91T). The C91T mutation caused a loss of 4-sulphatase activity, a detectable protein conformational change and a lower level of intracellular 4-sulphatase protein [Brooks, Robertson, Bindloss, Litjens, Anson, Peters, Morris and Hopwood (1995) Biochem. J. 307 , 457-463]. In the present study, we report...

... Society, London © 1999 1999 metal binding NMR spectroscopy protein conformation stability constant serum protein Biochem. J. (1999) 337, 105 111 (Printed in Great Britain) 105 N-lobe versus C-lobe complexation of bismuth by human transferrin Hongzhe SUN*, Hongyan LI*, Anne B. MASON‹, Robert C...