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Keywords: protein aggregation
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Biochem J (2021) 478 (14): 2733–2758.
Published: 23 July 2021
... models of neurodegenerative diseases, and its up-regulation is now being pursued in multiple clinical studies. Protein aggregation of the small protein α-Synuclein (αSyn) is proposed as an early contributor to the progression of PD. Gene dosage effects have been observed in a subset of PD patients...
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Biochem J (2020) 477 (18): 3471–3497.
Published: 23 September 2020
... to this work. 30 6 2020 23 8 2020 26 8 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 autophagy oligomerization protein aggregation protein quality control ubiquilins (UBQLNs) ubiquitin proteasome system Cells...
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Biochem J (2020) 477 (3): 629–643.
Published: 11 February 2020
...-lactalubumin β-casein mass spectrometry molecular chaperones protein aggregation protein conformation Globular proteins rely on the formation of discrete, low-energy, three-dimensional native structures in order to carry out their biological function [ 1 ]. As newly synthesised proteins...
Includes: Supplementary data
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Biochem J (2019) 476 (11): 1653–1677.
Published: 14 June 2019
... by promoting ADP to ATP exchange and substrate release. 5 3 2019 17 5 2019 21 5 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 Hsp70 J-protein molecular chaperone nucleotide exchange factor protein aggregation...
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Biochem J (2019) 476 (7): 1121–1135.
Published: 10 April 2019
... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . anhydrobiosis freeze–thaw neutron reflection protein aggregation stress tolerance Late embryogenesis...
Includes: Supplementary data
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Biochem J (2018) 475 (19): 3087–3103.
Published: 10 October 2018
... toxicity protein aggregation Among human neurodegenerative diseases, Alzheimer's disease (AD) is the most common, with nearly 47 million patients worldwide [ 1 ]. AD is characterized by a sequestration of amyloid β (Aβ) peptides into fibrillar aggregates that ultimately lead to neuronal cell death...
Includes: Supplementary data
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Biochem J (2018) 475 (10): 1701–1719.
Published: 18 May 2018
... of proteins. Owing to its ability to promote conformational changes in proteins leading to non-native states, TFE has largely been used to trigger protein aggregation. It has been shown for many proteins that intermediate concentrations of TFE promotes the conversion of proteins into native-like aggregation...
Includes: Supplementary data
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Biochem J (2016) 473 (17): 2655–2670.
Published: 30 August 2016
... accumulation of hA and its subsequent toxicity in pancreatic cells. human amylin lysosome proteasome protein aggregation proteotoxicity Islet amyloid polypeptide (IAPP) also known as amylin, is a pancreatic hormone produced and co-secreted with insulin from islet β-cells. Amylin is initially...
Includes: Supplementary data
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Biochem J (2016) 473 (14): 2087–2096.
Published: 12 July 2016
... cytotoxicity molecular mechanism protein aggregation protein stability Crystallins are the predominant soluble proteins in vertebrate lens. According to their elution positions on size-exclusion chromatography (SEC), crystallins can be categorized into three families (α-, β- and γ-crystallins...
Includes: Supplementary data
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Biochem J (2015) 466 (3): 561–570.
Published: 06 March 2015
...Alejandra Aguado; José Angel Fernández-Higuero; Yovana Cabrera; Fernando Moro; Arturo Muga The hexameric AAA + (ATPase associated with various cellular activities) chaperone ClpB reactivates protein aggregates in collaboration with the DnaK system. An intriguing aspect of ClpB function...
Includes: Supplementary data
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Biochem J (2012) 442 (3): 507–515.
Published: 24 February 2012
... 2012 amyloid β-peptide (Aβ) late embryogenesis abundant (LEA) protein protein aggregation polysaccharide traditional Chinese medicine The intraneuronal Aβ pool is generated intracellularly within the ER (endoplasmic reticulum) and Golgi system and is secreted as part...
Includes: Supplementary data
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Biochem J (2011) 434 (2): 201–210.
Published: 11 February 2011
... ROS stress include membrane lipid integrity and activity of ROS-susceptible proteins, including proteins required for faithful translation of mRNA. Protein oxidation also triggers accumulation of toxic protein aggregates or induction of apoptotic cell death. This burgeoning understanding...
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Biochem J (2010) 429 (2): 251–260.
Published: 28 June 2010
... correspondence should be addressed (email heath_ecroyd@uow.edu.au ). 22 12 2010 27 4 2010 4 5 2010 4 5 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 amyloid fibril casein dissociating agent disulfide bond micelle protein aggregation...
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Biochem J (2008) 415 (2): 275–288.
Published: 25 September 2008
...Satish Kumar; Vijay Kumar Ravi; Rajaram Swaminathan The early intermediates in the protein aggregation pathway, the elusive soluble aggregates, play a pivotal role in growth and maturation of ordered aggregates such as amyloid fibrils. Blocking the growth of soluble oligomers is an effective...
Includes: Supplementary data
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Biochem J (2007) 401 (1): 129–141.
Published: 11 December 2006
.../S45D/S59D αB-crystallin)] to undertake a comprehensive survey of their relative chaperone activity against different types of protein aggregation, i.e. disordered amorphous aggregation and ordered amyloid fibril formation. Amyloid fibril aggregation leads to highly structured cross-β-sheet fibrillar...
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Biochem J (2003) 375 (1): 33–40.
Published: 01 October 2003
... injury. 1 To whom correspondence should be addressed (e-mail christine.winterbourn@chmeds.ac.nz ). 9 5 2003 30 6 2003 9 7 2003 9 7 2003 The Biochemical Society, London ©2003 2003 haemoglobin myeloperoxidase myoglobin neutrophil protein aggregation protein...
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Biochem J (2003) 374 (3): 779–784.
Published: 15 September 2003
... formation could be modulated. amylin diabetes mellitus islet amyloid islet β-cell pancreas protein aggregation Abbreviations used: AM, acetoxymethyl ester; EthD-1, ethidium homodimer-1; hA, human amylin; (Pro 3 25,28,29 )hA: triprolyl hA; rA, rat amylin. Biochem. J. (2003) 374, 779 784...
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