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Keywords: polyamine
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Biochem J (2016) 473 (15): 2315–2329.
Published: 28 July 2016
...Anthony J. Michael Polyamines are evolutionarily ancient polycations derived from amino acids and are pervasive in all domains of life. They are essential for cell growth and proliferation in eukaryotes and are essential, important or dispensable for growth in bacteria. Polyamines present a useful...
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Biochem J (2014) 461 (3): 453–459.
Published: 10 July 2014
...Manuela Cervelli; Emanuela Angelucci; Pasquale Stano; Loris Leboffe; Rodolfo Federico; Giovanni Antonini; Paolo Mariottini; Fabio Polticelli SMO (spermine oxidase) and APAO (acetylpolyamine oxidase) are flavoenzymes that play a critical role in the catabolism of polyamines. Polyamines are basic...
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Biochem J (2013) 453 (3): 467–474.
Published: 12 July 2013
...Mervi T. Hyvönen; Taina Koponen; Janne Weisell; Marko Pietilä; Alex R. Khomutov; Jouko Vepsäläinen; Leena Alhonen; Tuomo A. Keinänen We have shown previously that the polyamine spermidine is indispensable for differentiation of 3T3-L1 preadipocytes. In the present study, we examined the mechanism...
Includes: Supplementary data
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Biochem J (2013) 452 (3): 423–432.
Published: 31 May 2013
...Radika Soysa; Hanka Venselaar; Jacqueline Poston; Buddy Ullman; Marie-Pierre Hasne The TcPOT1.1 gene from Trypanosoma cruzi encodes a high affinity putrescine-cadaverine transporter belonging to the APC (amino acid/polyamine/organocation) transporter superfamily. No experimental three-dimensional...
Includes: Supplementary data
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Biochem J (2013) 450 (3): 619–628.
Published: 28 February 2013
... small molecule metabolism. A LC (liquid chromatography)-MS screen in colorectal cancer cell lines isogenic for oncogenic PIK3CA mutations revealed an association between PI3K activation and the levels of polyamine pathway metabolites, including 5-methylthioadenosine, putrescine and spermidine...
Includes: Supplementary data
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Biochem J (2013) 450 (1): 47–53.
Published: 24 January 2013
... , that belong to the P 5 -ATPase group have been identified in humans. Mutations of the human gene ATP13A2 underlie a form of PD (Parkinson's disease). Previous studies have suggested a relation between polyamines and P 5B -ATPases. We have recently shown that the cytotoxicity induced by the polyamine analogue...
Includes: Supplementary data
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Biochem J (2012) 443 (3): 727–734.
Published: 16 April 2012
... or spermine to produce an acetyl polyamine and free form of CoA, which was used to measure SSAT activity after the DTNB reaction. The reaction mixtures containing 1 mM EDTA, 0–50 μM acetyl-CoA, 0–30 μg of the purified Ste27 recombinant protein and various amounts of substrates, including 0–200 μM...
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Biochem J (2011) 438 (2): 229–244.
Published: 12 August 2011
...Lyn-Marie Birkholtz; Marni Williams; Jandeli Niemand; Abraham I. Louw; Lo Persson; Olle Heby New drugs are urgently needed for the treatment of tropical and subtropical parasitic diseases, such as African sleeping sickness, Chagas' disease, leishmaniasis and malaria. Enzymes in polyamine...
Includes: Multimedia, Supplementary data
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Biochem J (2011) 433 (1): 139–144.
Published: 15 December 2010
...Anthony E. Pegg; Xiaojing Wang; Charles E. Schwartz; Diane E. McCloskey dcAdoMet (decarboxylated S -adenosylmethionine) is an essential intermediate in the synthesis of polyamines. Its content is normally very low, amounting to less than 5% of that of S -adenosylmethionine itself. It was found...
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Biochem J (2010) 430 (1): 151–159.
Published: 28 July 2010
... polyamines and especially quadrivalent spermine can be considered as potential regulators of the complex dynamical properties of anionic MTs (microtubules). Indeed, the C-terminal tails of tubulin display many negative residues in a row which should enable the formation of a correlated liquid-like phase...
Includes: Supplementary data
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Biochem J (2010) 429 (2): 261–271.
Published: 28 June 2010
... –Xpr–GFP) into the growing tube wall enhanced tube length and germination, consistent with a role of TGase as a modulator of cell wall building and strengthening. The secreted pollen TGase catalysed the cross-linking of both PAs (polyamines) into proteins (released by the pollen tube) and His 6 -Xpr...
Includes: Supplementary data
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Biochem J (2009) 424 (3): 431–438.
Published: 10 December 2009
...Andrew J. Palmer; Radiah A. Ghani; Navneet Kaur; Otto Phanstiel; Heather M. Wallace Increased polyamine concentrations play an important role in the development of cancer at all stages, from initiation through to maintenance of the transformed phenotype. One way cancer cells accumulate increased...
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Biochem J (2009) 421 (3): 323–338.
Published: 15 July 2009
...Robert A. Casero, Jr; Anthony E. Pegg In addition to polyamine homoeostasis, it has become increasingly clear that polyamine catabolism can play a dominant role in drug response, apoptosis and the response to stressful stimuli, and contribute to the aetiology of several pathological states...
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Biochem J (2008) 409 (2): 563–569.
Published: 21 December 2007
...Martin C. Taylor; Harparkash Kaur; Bernard Blessington; John M. Kelly; Shane R. Wilkinson The trypanocidal activity of the ODC (ornithine decarboxylase) inhibitor DFMO (difluoromethylornithine) has validated polyamine biosynthesis as a target for chemotherapy. As DFMO is one of only two drugs used...
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Biochem J (2008) 409 (1): 187–192.
Published: 11 December 2007
...Kristiina Kanerva; Laura T. Mäkitie; Anna Pelander; Marja Heiskala; Leif C. Andersson ODC (ornithine decarboxylase), the rate-limiting enzyme in polyamine biosynthesis, is regulated by specific inhibitors, AZs (antizymes), which in turn are inhibited by AZI (AZ inhibitor). We originally identified...
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Biochem J (2007) 407 (2): 243–254.
Published: 25 September 2007
...Sujoy Bhattacharya; Huazhang Guo; Ramesh M. Ray; Leonard R. Johnson Inhibition of ornithine decarboxylase by DFMO (α-difluromethylornithine) and subsequent polyamine depletion increases p21Cip1 protein, induces cell cycle arrest and confers resistance to apoptosis on intestinal epithelial cells...
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Biochem J (2006) 397 (3): 437–447.
Published: 13 July 2006
...Sujoy Bhattacharya; Ramesh M. Ray; Leonard R. Johnson Intestinal epithelial (IEC-6) cells are resistant to apoptosis following the inhibition of ODC (ornithine decarboxylase) and subsequent polyamine depletion. The depletion of polyamines rapidly activates NF-κB (nuclear factor κB) and STAT3...
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Biochem J (2006) 396 (2): 337–345.
Published: 15 May 2006
... by an energy-dependent mechanism the driving force of which is ΔΨ (electrical membrane potential). Although this process showed strict electrophoretic behaviour, qualitatively similar to that of polyamines, agmatine is most probably transported by a specific uniporter. Shared transport with polyamines by means...
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Biochem J (2006) 394 (1): 317–324.
Published: 27 January 2006
... carcinogenesis, in part, by a mechanism leading to the transcriptional activation of the gene encoding SSAT (spermidine/spermine N 1 -acetyltransferase), a rate-limiting enzyme in polyamine catabolism. In the present study, we show that a variety of NSAIDs, including aspirin, sulindac, ibuprofen and indomethacin...
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Biochem J (2005) 392 (2): 335–344.
Published: 22 November 2005
...Sujoy Bhattacharya; Ramesh M. Ray; Leonard R. Johnson Activation of STAT3 (signal transducer and activator of transcription 3) plays a crucial role in cell survival and proliferation. The aim of the present study was to clarify the role of STAT3 signalling in the protection of polyamine-depleted...
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Biochem J (2005) 385 (3): 779–785.
Published: 24 January 2005
...Kazuhiro NISHIMURA; Kaori MUROZUMI; Akira SHIRAHATA; Myung Hee PARK; Keiko KASHIWAGI; Kazuei IGARASHI To examine the roles of active hypusinated eIF5A (eukaryotic translation initiation factor 5A) and polyamines in cell proliferation, mouse mammary carcinoma FM3A cells were treated...
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Biochem J (2005) 385 (1): 21–28.
Published: 14 December 2004
...Ursula MANGOLD; Ekkehard LEBERER ODC (ornithine decarboxylase) is the rate-limiting enzyme in polyamine biosynthesis. Polyamines are essential for cellular growth and differentiation but enhanced ODC activity is associated with cell transformation. Post-translationally, ODC is negatively regulated...
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Biochem J (2004) 384 (1): 47–58.
Published: 09 November 2004
... polyamine transport, was defective in fluoro-BLM-A5 uptake and exhibited extreme resistance to the drug. A simple interpretation of these results is that BLM-A5 may enter the cell through the polyamine transport system. We showed further that after the uptake, fluoro-BLM-A5 accumulated into the vacuole...
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Biochem J (2004) 381 (3): 701–707.
Published: 27 July 2004
... activity. These results provide strong support for the concept that the levels of the higher polyamines spermidine and spermine are not determined only by the relative activities of the two aminopropyltransferases. Other factors such as availability of the aminopropyl donor substrate decarboxylated S...
Includes: Supplementary data
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Biochem J (2004) 379 (3): 849–855.
Published: 01 May 2004
... in mammals. 1 To whom correspondence should be addressed (e-mail aep1@psu.edu ). 6 1 2004 2 2 2004 6 2 2004 6 2 2004 The Biochemical Society, London ©2004 2004 agmatine arginine arginine decarboxylase ornithine polyamine Abbreviations used: ADC, l...
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Biochem J (2004) 377 (1): 257–264.
Published: 01 January 2004
... of both proteins, whereas the Raf/MEK/ERK pathway affects only the eukaryotic initiation factor 4E phosphorylation. Key words: ornithine decarboxylase, phosphoinositide 3-kinase, polyamine, Raf/MEK/ERK, Ras, translational regulation. INTRODUCTION The goal of the experiments described in the present study...
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Biochem J (2003) 375 (2): 465–470.
Published: 15 October 2003
...Ning QU; Natalia A. IGNATENKO; Phillip YAMAUCHI; David E. STRINGER; Corey LEVENSON; Patrick SHANNON; Scott PERRIN; Eugene W. GERNER Racemic difluoromethylornithine ( d / l -DFMO) is an inhibitor of ODC (ornithine decarboxylase), the first enzyme in eukaryotic polyamine biosynthesis. d / l -DFMO...
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Biochem J (2003) 374 (2): 481–488.
Published: 01 September 2003
...Alun HUGHES; Nicholas I. SMITH; Heather M. WALLACE Naproxen, sulindac and salicylate, three NSAIDs (non-steroidal anti-inflammatory drugs), were cytotoxic to human colorectal cancer cells in culture. Toxicity was accompanied by significant depletion of intracellular polyamine content. Inhibition...
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Biochem J (2003) 371 (2): 549–556.
Published: 15 April 2003
... with the presence of positively charged groups or apolar chains in the substrates. In particular, it was found that the docking of the physiological polyamines, i.e. spermidine and spermine, appears to be modulated by three amino acid residues of the active site, which we have named L - H + , G - H + and IH...
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Biochem J (2002) 367 (3): 665–675.
Published: 01 November 2002
...Slavoljub VUJCIC; Paula DIEGELMAN; Cyrus J. BACCHI; Debora L. KRAMER; Carl W. PORTER During polyamine catabolism, spermine and spermidine are first acetylated by spermidine/spermine N 1 -acetyltransferase (SSAT) and subsequently oxidized by polyamine oxidase (PAO) to produce spermidine...
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Biochem J (2002) 364 (3): 767–775.
Published: 15 June 2002
... for cationic, neutral or anionic amino acids or for the polyamine putrescine. In addition, human glioblastoma cells stably overexpressing a fusion protein between SLC7A4 and the enhanced green fluorescent protein (EGFP) did not exhibit an increased transport activity for l -arginine. The lack of transport...
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Biochem J (2000) 345 (1): 69–75.
Published: 17 December 1999
... development. At weaning time, an increase in the intestinal level of polyamines (and especially that of spermine) was observed, owing partly to the higher level of spermine found in solid food given to rats at this period in comparison with the level found in milk. To study the role of this polyamine...
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Biochem J (1999) 340 (3): 753–758.
Published: 08 June 1999
...Dale P. WOOLRIDGE; Jesse D. MARTINEZ; David E. STRINGER; Eugene W. GERNER Overexpression of the BltD gene in Bacillus subtilis causes acetylation of the polyamines spermidine and spermine. BltD is co-regulated with another gene, Blt , which encodes a multidrug export protein whose overexpression...