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Keywords: point mutations
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Biochem J (2023) 480 (12): 875–890.
Published: 22 June 2023
... intracellular signaling point mutations protein kinase A protein–protein interactions PKAc-PKI structures were modeled using AlphaFold2_Advanced (ColabNotebook). Sequences used for modeling were derived from Uniprot (PRKACA-P17612, PKIA-P61925) and modified to include relevant Cushing's PKAc...
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Biochem J (2020) 477 (15): 2755–2770.
Published: 07 August 2020
... and biological functions of RIT1 remain elusive, and more insight into its pathophysiological contributions are needed to create effective therapeutic interventions for patients harboring RIT1 mutations. cancer GTPases point mutations stress response © 2020 The Author(s). Published by Portland...
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Biochem J (2020) 477 (6): 1083–1087.
Published: 18 March 2020
... interests associated with this manuscript. kinetic stability point mutations protein conformation sequence evolution statistical model thermodynamics The extant sequences of proteins are a product of innumerable mutational iterations over the evolutionary timeline. Mutations can manifest...