... 4 1 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 insulin signalling phosphoinositide 3-kinase (PI3K) pleckstrin homology domain (PH domain) protein tyrosine phosphatase tandem pleckstrin homology-domain-containing protein (TAPP) The PI3K...

... carcinoma cell epidermal growth factor (EGF) phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5) P 3 ] phosphoinositide phosphoinositide 3-kinase (PI3K) pleckstrin homology domain (PH domain) PI3Ks (phosphoinositide 3-kinases) are key regulators of many cellular responses. The class I...

... pleckstrin homology domain (PH domain) polyphosphoinositide subcellular localization CerK (ceramide kinase) was identified recently by Sugiura et al. [ 1 ]. It is so far the only established enzyme that uses ceramide as a substrate to produce C1P (ceramide 1-phosphate). A CerK-like protein as well...

... homology domain (PH domain) tryptophan fluorescence The dynamins comprise a family of large GTPases, many of which play critical roles in several types of vesicular fission events (for reviews, see [ 1 – 5 ]). Their participation in endocytosis at the plasma membrane is thought...

... pleckstrin homology domain (PH domain) PH-PLCδ 1 [the PH domain (pleckstrin homology domain) of PLCδ 1 (phospholipase C-δ 1 )] was the first PH domain shown to bind with high affinity and stereospecificity to a particular membrane phosphoinositide [PtdIns(4,5) P 2 ] [ 1 , 2 ], by recognizing its...