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Keywords: phosphatidylbutanol
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Phospholipase D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase Cδ

Anna GHELLI, Anna M. PORCELLI, Annalisa FACCHINI, Silvana HRELIA, Flavio FLAMIGNI, Michela RUGOLO
Journal: Biochemical Journal
Biochem J (2002) 366 (1): 187–193.
DOI: https://doi.org/10.1042/bj20020264
Published: 15 August 2002
..., a significant reduction in phosphatidylbutanol formation by SPP was observed in the presence of 4-amino-5-(4-methylphenyl)-7-(t-butyl) pyrazolo [3,4-d] pyrimidine (PP1), an inhibitor of Src tyrosine kinase. Furthermore, the activity of Src kinase was slightly increased by SPP and inhibited by PP1. However...
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Phospholipase D1b and D2a generate structurally identical phosphatidic acid species in mammalian cells

Trevor R. PETTITT, Mark McDERMOTT, Khalid M. SAQIB, Neil SHIMWELL, Michael J. O. WAKELAM
Journal: Biochemical Journal
Biochem J (2001) 360 (3): 707–715.
DOI: https://doi.org/10.1042/bj3600707
Published: 10 December 2001
...- and PLD2a-transfected PAE cells, as well as COS7 and Rat1 cells, generate similar PtdOH and, in the presence of butan-1-ol, phosphatidylbutanol (PtdBut) profiles, enriched in mono- and di-unsaturated species, in particular 16:0/18:1. Although PtdBut mass increased, the species profile did not change...
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