... reveal phase separation to be the principle mechanism behind the self-association of shell protein in the presence of salts and macromolecular crowding. The shell protein PduBB′ interacts with the enzyme diol-dehydratase PduCDE and co-assemble into phase separated liquid droplets. The co-assembly...

... ( ttrcekp1@jhu.edu ) * These authors contributed equally to this work. 9 9 2022 8 11 2022 11 11 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 germ cell germ granules nuage P granules phase separation RNA...

...Lior Pytowski; David J. Vaux; Létitia Jean Many protein misfolding diseases (e.g. type II diabetes and Alzheimer's disease) are characterised by amyloid deposition. Human islet amyloid polypeptide (hIAPP, involved in type II diabetes) spontaneously undergoes liquid–liquid phase separation (LLPS...

... a liquid–liquid phase separation process. These exciting ideas impacted the SR field by raising the hypothesis of SR foci as liquid condensates involved in transcriptional regulation. In this work, we review the current knowledge about SR foci formation under the light of the condensate model, analyzing...

... 9 2 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 disaggregase neurodegeneration phase separation prion-like domain RNA-binding proteins The problem of neurodegeneration remains a pressing public health concern...