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Keywords: phase separation
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Biochem J (2023) 480 (22): 1833–1844.
Published: 21 November 2023
... proteins, can direct PRC2 to its targets. In this report, we demonstrate that a PCL protein named PHF1 forms phase-separated condensates at H3K27me3 loci that recruit PRC2. Combining cellular observation and biochemical reconstitution, we show that the N-terminal domains of PHF1 cooperatively mediate...
Includes: Supplementary data
Biochem J (2023) 480 (8): 539–553.
Published: 26 April 2023
... reveal phase separation to be the principle mechanism behind the self-association of shell protein in the presence of salts and macromolecular crowding. The shell protein PduBB′ interacts with the enzyme diol-dehydratase PduCDE and co-assemble into phase separated liquid droplets. The co-assembly...
Includes: Multimedia, Supplementary data
Biochem J (2022) 479 (24): 2477–2495.
Published: 19 December 2022
... ]. In vitro and in vivo experiments demonstrated that RNA promotes phase separation of diverse proteins and that it is required for the formation and maintenance of RNA granules [ 8 , 26–37 ]. In agreement with these observations, RNA also enhances condensation of MEG-3 and hence the formation of P...
Biochem J (2021) 478 (2): 443–461.
Published: 29 January 2021
... a liquid–liquid phase separation process. These exciting ideas impacted the SR field by raising the hypothesis of SR foci as liquid condensates involved in transcriptional regulation. In this work, we review the current knowledge about SR foci formation under the light of the condensate model, analyzing...
Biochem J (2017) 474 (8): 1417–1438.
Published: 07 April 2017
... 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 disaggregase neurodegeneration phase separation prion-like domain RNA-binding proteins It is now estimated that up to 50% of ALS patients also suffer from cognitive impairment...